MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 530 to 579 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
265	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Divided	24806.9	20369.9	1.21782
266	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158]	Subtracted	11222.2	9948.93	1273.27
267	cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552]
	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Divided	14021.4	11523	1.21682
268	catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	Subtracted	11222.2	9948.93	1273.27
	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	24473.9	20127.8	1.21593
269	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	Subtracted	4808.79	6074.21	1265.42
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	Divided	4590.18	5575.52	1.21466
270	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]		23640.2	19479.8	1.21358
	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	Subtracted	4810.22	6075.04	1264.82
271	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Divided	2554.89	3093.78	1.21092
	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	Subtracted	4812.01	6076.09	1264.08
272	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Divided	3858.52	4669.27	1.21012
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Subtracted	1991.03	3221.38	1230.35
273	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Divided	3199.4	3870.8	1.20985
	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Subtracted	5181.2	6410.58	1229.38
274	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Divided	3119.98	2579.49	1.20953
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Subtracted	5181.2	6410.58	1229.38
275	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]		10264.9	9043.51	1221.39
	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Divided	3119.98	2579.49	1.20953
276	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted	699.76	1894.39	1194.63
	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Divided	3119.98	2579.49	1.20953
277	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	Subtracted	8600.02	9792.49	1192.47
	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Divided	3119.98	2579.49	1.20953
278	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	Subtracted	8600.02	9792.49	1192.47
	transcription factor lbx1. [swissprot;acc:p52954]	Divided	3119.98	2579.49	1.20953
279	mosaic protein lgn. [swissprot;acc:p81274]
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	Subtracted	4771.21	5961.43	1190.22
280	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		677.5	1865.5	1188
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Divided	3119.98	2579.49	1.20953
281	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Subtracted	677.5	1865.5	1188
282	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Divided	3119.98	2579.49	1.20953
283	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Subtracted	677.5	1865.5	1188
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	Divided	5221.28	6314.35	1.20935
284	paxillin. [swissprot;acc:p49023]
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Subtracted	677.5	1865.5	1188
285	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]		4068.56	5252.6	1184.04
	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	Divided	23326.5	19296.4	1.20885
286	exocyst complex component sec5. [swissprot;acc:q96kp1]		23316	19288.8	1.20878
	rna-binding protein. [refseq;acc:nm_019027]	Subtracted	4069.83	5252.17	1182.34
287	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
	poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3]	Divided	23303.1	19279.5	1.2087
288	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]		23422.4	19380.3	1.20857
	ns1-associated protein 1. [refseq;acc:nm_006372]	Subtracted	4069.83	5252.17	1182.34
289	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]
	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	Divided	4682.88	5646.19	1.20571
290	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Subtracted	4071.1	5251.75	1180.65

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.