MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	Value Type	Rank	network_comparison	Interaction Map	description	red	Filtered	green

Results: HTML CSV LaTeX

Showing element 518 to 567 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	description	red	green
518	1.14051	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	4910.6	5600.61
519	1.13957	glycogen [starch] synthase, muscle (ec 2.4.1.11). [swissprot;acc:p13807]	9648.27	10994.9
520	1.13941	endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	9642.22	10986.4
521	1.13937	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	5390.78	6142.07
522	1.1392	glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	9634.98	10976.2
523	1.13887	aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	10640.2	12117.8
524		aquaporin 5. [swissprot;acc:p55064]	10640	12117.6
525		lens fiber major intrinsic protein (mip26) (mp26) (aquaporin 0). [swissprot;acc:p30301]	10639.8	12117.3
526	1.13886	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	10639.9	12117.4
527		protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]	4775.11	5438.18
528	1.13879	aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	10635.3	12111.4
529	1.13866	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	8600.02	9792.49
530		peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]
531	1.13863	transcription initiation factor iib (general transcription factor tfiib) (s300-ii). [swissprot;acc:q00403]	4651.88	5296.78
532		thyroid receptor interacting protein 3 (trip-3) (fragment). [swissprot;acc:q15649]
533		nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]
534		nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345]
535	1.13826	translocon-associated protein, delta subunit precursor (trap-delta) (signal sequence receptor delta subunit) (ssr-delta). [swissprot;acc:p51571]	10603.5	12069.5
536		calsyntenin-1 precursor. [swissprot;acc:o94985]
537		succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]
538	1.13825	protein-tyrosine phosphatase beta precursor (ec 3.1.3.48) (r-ptp- beta). [swissprot;acc:p23467]		12069.4
539		thymus-specific serine protease precursor (ec 3.4.-.-). [swissprot;acc:q9nqe7]
540		gk001 protein. [refseq;acc:nm_020198]
541	1.13819	calsyntenin-2 precursor. [swissprot;acc:q9h4d0]	10600.3	12065.2
542		rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	3889.27	4426.74
543		calsyntenin-3 precursor. [swissprot;acc:q9bqt9]	10599.9	12064.7
544		rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	3889.27	4426.74
545		rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]
546	1.13812	zinc finger protein t86. [swissprot;acc:o00488]	4052.77	4612.54
547	1.13762	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	5291.92	6020.19
548	1.13759	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	8268.19	9405.85
549	1.13731	dolichol-phosphate mannosyltransferase (ec 2.4.1.83) (dolichol- phosphate mannose synthase) (dolichyl-phosphate beta-d- mannosyltransferase) (mannose-p-dolichol synthase) (mpd synthase) (dpm synthase). [swissprot;acc:o60762]	5865.79	6671.23
550	1.13687	prohibitin. [swissprot;acc:p35232]	5773.45	6563.69
551		repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]
552	1.13663	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	15427.2	13572.8
553	1.13651	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	3853.64	4379.71
554	1.13641	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	14830.5	13050.3
555	1.13615	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	6167.93	7007.7
556		flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]
557		inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]
558		selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]
559		inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]
560	1.13536	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]	5480.24	6222.04
561		transforming protein rhoc (h9). [swissprot;acc:p08134]
562		thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]
563		3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]
564		transforming protein rhoa (h12). [swissprot;acc:p06749]
565	1.1353	small glutamine-rich tetratricopeptide repeat-containing protein (vpu-binding protein) (ubp). [swissprot;acc:o43765]	10434.4	11846.2
566	1.13506	autoantigen ngp-1. [swissprot;acc:q13823]	3766.14	4274.79
567		deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]	10264.9	9043.51

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.