MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Filtered	Gene	green	Value Type	Interaction Map	Network Comparison Type	network_comparison	red

Results: HTML CSV LaTeX

Showing element 551 to 600 of 38536 in total

Network Comparison Type  : Divided

description	Rank	Filtered	green	Value Type	Interaction Map	network_comparison	red
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	2644	1	76.8115	Rooted	Low confidence	1.03323	74.3411
	4323		46959.8	Squared		1.024	48087
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	949		199.196	Ranked		1.02485	204.147
	971		65.1892	Rooted	High confidence	1.05715	61.6649
	1083		213.685	Ranked		1.03011	220.118
	1140		73.8482	Rooted	Low confidence	1.03831	71.1233
	1274		6371.14	Measured	High confidence	1.08261	5885
	1626		43316.1	Squared	Low confidence	1.04269	45165.2
	2082		8138.17	Measured		1.03178	7887.47
	2609		30015.7	Squared	High confidence	1.03735	28935
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	950		199.196	Ranked	Low confidence	1.02485	204.147
	972		65.1892	Rooted	High confidence	1.05715	61.6649
	1084		213.685	Ranked		1.03011	220.118
	1143		73.8482	Rooted	Low confidence	1.03831	71.1233
	1275		6371.14	Measured	High confidence	1.08261	5885
	1627		43316.1	Squared	Low confidence	1.04269	45165.2
	2090		8138.17	Measured		1.03178	7887.47
	2610		30015.7	Squared	High confidence	1.03735	28935
3-oxo-5-beta-steroid 4-dehydrogenase (ec 1.3.99.6) (delta(4)-3- ketosteroid 5-beta-reductase) (aldo-keto reductase family 1 member d1). [swissprot;acc:p51857]	1902		197.384	Ranked	Low confidence	1.01977	201.286
	2018		74.9328	Rooted		1.03503	72.3967
	2235		8361.72	Measured		1.03133	8107.73
	3174		44839.4	Squared		1.03457	46389.7
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	897		283.472	Ranked	High confidence	1.03882	272.878
	2394		42.7253	Rooted		1.01582	43.4014
	2513		42545.5	Squared	Low confidence	1.03844	44180.9
	2547		3444.18	Measured	High confidence	1.02187	3370.46
	2650		16197	Squared		1.02847	16658.1
	3553		7932.5	Measured	Low confidence	1.0257	7733.78
	4104		71.9424	Rooted		1.02615	70.109
	4765		205.83	Ranked		1.00492	206.842
38 kda fk-506 binding protein homolog (fkbpr38) (fk506-binding protein 8). [swissprot;acc:q14318]	116		45948.1	Squared		1.14667	52687.3
	1826		69.9589	Rooted	High confidence	1.03048	67.8897
	2068		207.631	Ranked	Low confidence	1.01932	203.696
	2261		6786.23	Measured	High confidence	1.04615	6486.84
	2358		197.346	Ranked		1.00423	198.181
	2710		28336.5	Squared		1.01489	27920.7
	3779		8198.63	Measured	Low confidence	1.02419	8396.92
	4988		72.2334	Rooted		1.0032	72.4649
4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	36	0	2.18581		High confidence	1.96964	4.30525
	121		14.3333	Measured		1.3721	19.6667
	232		0.145878	Squared		1.34278	0.108639
	369		19704.7	Ranked		1.04536	18849.7
	481		10788.6		Low confidence	1.0617	11454.3
	680		33.079	Rooted		1.02264	32.3467
	696	1	26693.1	Squared	High confidence	1.17186	22778.5
	727		8803.2	Measured	Low confidence	1.04261	8443.4
	740	0	32991.9	Squared		1.02063	33672.5
	815		3822.12	Measured		1.00257	3831.93
	1469	1	5887.45		High confidence	1.07571	5473.09
	1579		77.0332	Rooted	Low confidence	1.0362	74.3423

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.