MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Filtered	green	Interaction Map	red	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 66312 in total

Filtered  : 1

Rank	description	Value Type	Network Comparison Type	green	Interaction Map	red	network_comparison
32	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	Ranked	Subtracted	336.074	High confidence	267.142	68.932
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Measured	Divided	895.893		1834.73	2.04793
	implantation-associated protein. [refseq;acc:nm_032121]		Subtracted	5058.5	Low confidence	3278	1780.5
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Squared	Divided	61881.5		82347.8	1.33073
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Measured	Subtracted	18263	High confidence	23693.7	5430.7
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Rooted	Divided	168.796	Low confidence	145.551	1.1597
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Measured		43368.8		36360.3	1.19275
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Squared	Subtracted	192141	High confidence	106226	85915
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Ranked	Divided	232.49	Low confidence	273.188	1.17505
	regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924]		Subtracted	219.841		247.768	27.927
	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]		Divided	243.673	High confidence	187.462	1.29985
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Rooted	Subtracted	49.1529	Low confidence	38.4152	10.7377
33	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	Ranked		200.55		228.147	27.597
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Squared		56522.1		77316.3	20794.2
	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	Ranked	Divided	246.125		210.241	1.17068
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]		Subtracted	336.073	High confidence	267.144	68.929
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Measured	Divided	896.972		1835.3	2.04611
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Squared		61881.5	Low confidence	82347.8	1.33073
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Measured	Subtracted	18263	High confidence	23693.7	5430.7
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Squared		192141		106226	85915
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Rooted		43.561		25.6987	17.8623
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		Divided	43.1914		26.0288	1.65937
	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]			88.6244	Low confidence	76.5734	1.15738
	septin 6. [swissprot;acc:q14141]	Measured	Subtracted	14773.7		13005.8	1767.9
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	Ranked	Divided	242.742	High confidence	188.688	1.28647
	spermatogenesis associated 6. [refseq;acc:nm_019073]	Squared		25146.6		9924.76	2.53372
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Rooted	Subtracted	49.2633	Low confidence	38.5678	10.6955
	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Measured	Divided	43368.8		36360.3	1.19275
34	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	Squared		25146.6	High confidence	9924.76	2.53372
	bcl2-related ovarian killer. [refseq;acc:nm_032515]	Rooted	Subtracted	61.2591	Low confidence	50.6099	10.6492
	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	Measured		7251		5492.04	1758.96
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Rooted		122.878	High confidence	140.508	17.63
	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	Ranked		200.532	Low confidence	227.371	26.839
	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]			336.073	High confidence	267.144	68.929
	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Measured	Divided	907.546		1836.71	2.02382
		Rooted		24.3678		40.2812	1.65305
	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Squared	Subtracted	61881.5	Low confidence	82347.8	20466.3
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		Divided				1.33073
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Measured	Subtracted	18263	High confidence	23693.7	5430.7
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Squared		192141		106226	85915
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Measured	Divided	6352.4	Low confidence	5339.5	1.1897
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked		133.876		155.56	1.16197
	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Rooted		56.755		49.0544	1.15698
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	Ranked		242.453	High confidence	189.07	1.28235
35	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Squared		192141		106226	1.80879
	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Rooted	Subtracted	122.878		140.508	17.63
	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Ranked		240.822	Low confidence	267.448	26.626
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Measured	Divided	39358.1		33111.4	1.18866
	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	Ranked	Subtracted	335.359	High confidence	267.636	67.723
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Measured	Divided	907.564		1836.71	2.02378

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.