Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Value Type Rank Network Comparison Type description red Interaction Map Filtered network_comparison green
Results: HTML CSV LaTeX Showing element 501 to 550 of 6456 in total
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
Network Comparison Type
description
red
network_comparison
green
251 Divided tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631] 6417.18 1.22477 7859.6
Subtracted breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567] 4579.34 1361.3 5940.64
252 Divided crk-like protein. [swissprot;acc:p46109] 6417.18 1.22477 7859.6
Subtracted glycogen [starch] synthase, muscle (ec 2.4.1.11). [swissprot;acc:p13807] 9648.27 1346.63 10994.9
253 Divided proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519] 6417.18 1.22477 7859.59
Subtracted endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759] 9642.22 1344.18 10986.4
254 Divided proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241] 6417.18 1.22477 7859.6
Subtracted glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840] 9634.98 1341.22 10976.2
255 Divided proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769] 6417.18 1.22477 7859.6
Subtracted mad protein (max dimerizer). [swissprot;acc:q05195] 4455.95 1318.08 5774.03
256 Divided grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791] 6417.19 1.22476 7859.51
Subtracted max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539] 4456.67 1317.1 5773.77
257 Divided ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880] 6417.31 1.22452 7858.12
Subtracted max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582] 4456.93 1316.74 5773.67
258 Divided homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529] 6417.33 1.22449 7857.93
Subtracted max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300] 4457.06 1316.57 5773.63
259 Divided neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401] 6417.81 1.22355 7852.52
Subtracted small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331] 4569.48 1316.31 5885.79
260 Divided signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] 4244.95 1.22343 5193.42
Subtracted cytidine triphosphate synthase ii; ctp synthetase type 2; utp-ammonia ligase; ctp synthetase isoform; cytidine 5'-triphosphate synthetase 2. [refseq;acc:nm_019857] 12515.4 1294.3 11221.1
261 Divided signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458] 4247.36 1.22255 5192.61
Subtracted source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862] 4571.89 1292.97 5864.86
262 Divided cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693] 24896.4 1.21852 20431.7
Subtracted oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977] 4571.89 1292.97 5864.86
263 Divided trs85 homolog. [swissprot;acc:q9y2l5] 24896.4 1.21852 20431.7
Subtracted dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656] 4571.89 1292.97 5864.86
264 Divided cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653] 4987.58 1.2181 4094.57
Subtracted ctp synthase (ec 6.3.4.2) (utp--ammonia ligase) (ctp synthetase). [swissprot;acc:p17812] 12503.3 1291.3 11212
265 Divided wd-repeat protein wdc146. [swissprot;acc:q9c0j8] 24806.9 1.21782 20369.9
Subtracted splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533] 4638.1 1285.3 5923.4
266 Divided cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570] 24806.9 1.21782 20369.9
Subtracted solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158] 11222.2 1273.27 9948.93
267 Divided ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967] 14021.4 1.21682 11523
Subtracted cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552] 11222.2 1273.27 9948.93
268 Divided cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0] 24473.9 1.21593 20127.8
Subtracted catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798] 11222.2 1273.27 9948.93
269 Divided u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777] 4590.18 1.21466 5575.52
Subtracted crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945] 4808.79 1265.42 6074.21
270 Divided fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917] 23640.2 1.21358 19479.8
Subtracted t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991] 4810.22 1264.82 6075.04
271 Divided chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0] 2554.89 1.21092 3093.78
Subtracted enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511] 4812.01 1264.08 6076.09
272 Divided histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929] 3858.52 1.21012 4669.27
Subtracted nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09] 1991.03 1230.35 3221.38
273 Divided eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010] 3199.4 1.20985 3870.8
Subtracted ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424] 5181.2 1229.38 6410.58
274 Divided chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286] 3119.98 1.20953 2579.49
Subtracted ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464] 5181.2 1229.38 6410.58
275 Divided regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795] 3119.98 1.20953 2579.49
Subtracted deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316] 10264.9 1221.39 9043.51

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/