MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	Interaction Map	Value Type	description	Network Comparison Type	green	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	Network Comparison Type	green	red	network_comparison
13	Squared	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Divided	388.696	37.5863	10.3414
		melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Subtracted	129762	219048	89286
	Rooted	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		101.526	80.4705	21.0555
		cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Divided	35.798	19.9625	1.79326
14	Measured	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Subtracted	27904.5	21591.5	6313
		ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Divided	1281.5	398.5	3.21581
	Ranked	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]		75.3531	56.6768	1.32952
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Subtracted	336.191	266.863	69.328
	Squared	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		129762	219048	89286
		ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Divided	388.696	37.5863	10.3414
	Rooted			35.798	19.9625	1.79326
		spermatogenesis associated 6. [refseq;acc:nm_019073]	Subtracted	101.526	80.4705	21.0555
15	Measured	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]		27904.5	21591.5	6313
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Divided	871	2671	3.06659
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Subtracted	336.19	266.863	69.327
		microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Divided	75.3948	56.7244	1.32914
	Squared	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Subtracted	129762	219048	89286
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Divided	179.56	1688.58	9.40399
	Rooted	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	Subtracted	101.526	80.4705	21.0555
		gbp protein isoform a. [refseq;acc:nm_017870]	Divided	42.4773	23.9771	1.77158
16	Measured	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Subtracted	18172.1	24260.3	6088.2
		protein x 0004. [refseq;acc:nm_016301]	Divided	871	2671	3.06659
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Subtracted	336.184	266.864	69.32
		microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Divided	75.3954	56.7252	1.32913
	Squared	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Subtracted	129762	219048	89286
		protein x 0004. [refseq;acc:nm_016301]	Divided	179.56	1688.58	9.40399
	Rooted	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	182.638	203.673	21.035
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Divided	29.5127	51.6817	1.75117
17	Measured	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]		1365	460	2.96739
		microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Subtracted	18168.9	24255.7	6086.8
	Ranked	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Divided	75.447	56.7841	1.32866
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Subtracted	336.182	266.864	69.318
	Squared	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Divided	441	50.0828	8.80542
		necdin. [swissprot;acc:q99608]	Subtracted	129762	219048	89286
	Rooted	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		182.638	203.673	21.035
		protein x 0004. [refseq;acc:nm_016301]	Divided	29.5127	51.6817	1.75117
18	Measured	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Subtracted	18168.9	24255.7	6086.8
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided	1865.5	677.5	2.75351
	Ranked	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		245.247	185.678	1.32082
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Subtracted	336.181	266.865	69.316
	Squared	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		129762	219048	89286
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided	823.69	108.641	7.58176
	Rooted	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted	182.638	203.673	21.035
		dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Divided	36.9459	21.4476	1.72261
19	Measured	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Subtracted	18164.9	24250	6085.1
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided	1865.5	677.5	2.75351
	Ranked	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]		245.247	185.678	1.32082
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Subtracted	336.178	266.865	69.313
	Squared	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		129762	219048	89286
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided	823.69	108.641	7.58176

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.