Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank description Gene Value Type Interaction Map Network Comparison Type Filtered green network_comparison red
Results: HTML CSV LaTeX Showing element 51 to 100 of 7460 in total
Value Type  : Ranked
Interaction Map  : High confidence
Rank
description
Network Comparison Type
Filtered
green
network_comparison
red
13 heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107] Divided 0 9264.5 1.77804 5210.5
protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] 1 212.554 1.3585 288.754
14 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 75.3531 1.32952 56.6768
dystrophin. [swissprot;acc:p11532] 0 18054.8 1.76446 10232.5
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] Subtracted 1 336.191 69.328 266.863
ubiquitin protein ligase. [refseq;acc:nm_130466] 0 15339.2 7816.2 7523
15 guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4] 14964 7458 22422
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] 1 336.19 69.327 266.863
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] Divided 75.3948 1.32914 56.7244
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521] 0 11267 1.72211 19403
16 cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946] 20670.6 1.69839 12170.7
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] Subtracted 1 336.184 69.32 266.864
microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] Divided 75.3954 1.32913 56.7252
ptd016 protein. [refseq;acc:nm_016125] Subtracted 0 11234 6816 18050
17 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] Divided 1 75.447 1.32866 56.7841
ero1-like. [refseq;acc:nm_014584] Subtracted 0 20536 6683 13853
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] Divided 6812 1.69451 11543
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] Subtracted 1 336.182 69.318 266.864
18 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] Divided 245.247 1.32082 185.678
fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757] Subtracted 0 14178.1 6668.71 7509.39
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] 1 336.181 69.316 266.865
homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017] Divided 0 13216 1.68629 22286
19 glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216] 1 245.247 1.32082 185.678
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] Subtracted 336.178 69.313 266.865
homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630] Divided 0 13216 1.68629 22286
nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8] Subtracted 11083.9 6608.06 4475.84
20 glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737] Divided 1 245.247 1.32082 185.678
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152] Subtracted 336.159 69.291 266.868
homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056] Divided 0 13216 1.68629 22286
serpin b12. [swissprot;acc:q96p63] Subtracted 21138.6 6534.4 14604.2
21 acrc protein; putative nuclear protein. [refseq;acc:nm_052957] Divided 10621.4 1.68236 6313.38
gbp protein isoform a. [refseq;acc:nm_017870] Subtracted 1 256.492 69.094 325.586
hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8] 0 21113.7 6521.7 14592
myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7] Divided 1 245.247 1.32082 185.678
22 glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]
protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256] Subtracted 253 69 322
pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129] Divided 0 12479 1.68195 20989
ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855] Subtracted 11965.7 6455.2 5510.5
23 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] Divided 1 44 1.31818 58
hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712] 0 9285.44 1.67148 15520.4
Subtracted 6234.96
microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083] 1 253 69 322
24 ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5] Divided 0 8257 1.66289 13730.5
pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] 1 44 1.31818 58
protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726] Subtracted 253 69 322
sedlin. [swissprot;acc:o14582] 0 16388 6052 22440
25 ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485] 1 253 69 322
lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851] Divided 0 8257 1.66289 13730.5
pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23] 1 44 1.31818 58
synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] Subtracted 0 16388 6052 22440

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/