MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Network Comparison Type	Value Type	red	Gene	network_comparison	Interaction Map	green	Rank	Filtered	description

Results: HTML CSV LaTeX

Showing element 451 to 500 of 25824 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

red	network_comparison	green	Rank	description
0.00001	1	0.00001	3206	protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]
			3207	complement component c8 beta chain precursor. [swissprot;acc:p07358]
			3208	runt-related transcription factor 3 (core-binding factor, alpha 3 subunit) (cbf-alpha 3) (acute myeloid leukemia 2 protein) (oncogene aml-2) (polyomavirus enhancer binding protein 2 alpha c subunit) (pebp2-alpha c) (pea2-alpha c) (sl3-3 enhancer factor 1 alpha c subunit) (sl3/akv core-binding factor alpha c subunit). [swissprot;acc:q13761]
			3209	cdk-activating kinase assembly factor mat1 (ring finger protein mat1) (menage a trois) (cdk7/cyclin h assembly factor) (p36) (p35) (cyclin g1 interacting protein). [swissprot;acc:p51948]
			3210	trabid protein. [swissprot;acc:q9ugi0]
			3211	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]
			3212	rala binding protein 1; rala-binding protein. [refseq;acc:nm_006788]
			3213	malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925]
			3214	bs4 protein (ny-ren-18 antigen). [swissprot;acc:q9y5a7]
			3215	membrane-bound transcription factor site 2 protease (ec 3.4.24.-) (site-2 protease) (sterol-regulatory element-binding proteins intramembrane protease). [swissprot;acc:o43462]
			3216	dna excision repair protein ercc-1. [swissprot;acc:p07992]
			3217	sex comb on midleg homolog 1. [refseq;acc:nm_012236]
			3218	williams-beuren syndrome chromosome region 14 protein (ws basic-helix- loop-helix leucine zipper protein) (ws-bhlh) (mlx interactor). [swissprot;acc:q9np71]
			3219	protein c6orf55 (dopamine responsive protein drg-1) (my012 protein) (hspc228). [swissprot;acc:q9np79]
			3220	transcription factor ap-2 beta (ap2-beta) (activating enhancer-binding protein 2 beta). [swissprot;acc:q92481]
			3221	platelet-activating factor acetylhydrolase ib alpha subunit (ec 3.1.1.47) (paf acetylhydrolase 45 kda subunit) (paf-ah 45 kda subunit) (paf-ah alpha) (pafah alpha) (lissencephaly-1 protein) (lis- 1). [swissprot;acc:p43034]
			3222	aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]
			3223	ras-related protein ral-a. [swissprot;acc:p11233]
			3224	integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]
			3225	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]
			3226	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]
			3227	69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]
			3228	ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]
398.5	3.21581	1281.5	9	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]
			10	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]
			11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]
			12	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]
			13	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]
			14	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]
450.5	5.31521	2394.5	1	rad50-interacting protein 1. [refseq;acc:nm_021930]
			2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]
460	2.96739	1365	17	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]
677.5	2.75351	1865.5	18	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]
			19	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]
			20	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]
			21	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
			22	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]
699.76	2.7072	1894.39	23	gbp protein isoform a. [refseq;acc:nm_017870]
779.167	1.78438	1390.33	46	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]
			47	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]
			48	doc-1 related protein (doc-1r). [swissprot;acc:o75956]
			49	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]
			50	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]
			51	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]
			52	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]
			53	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]
950.561	2.21818	2108.52	24	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]
1153.5	3.39764	339.5	5	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]
			6	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]
			7	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.