Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank description Value Type red Network Comparison Type Interaction Map network_comparison Filtered green
Results: HTML CSV LaTeX Showing element 451 to 500 of 25824 in total
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Value Type
red
Network Comparison Type
network_comparison
green
57 kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558] Measured 1631.67 Divided 1.63302 2664.55
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] Squared 219048 1.68808 129762
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] Rooted 137.446 Subtracted 16.623 120.823
myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7] Ranked 185.678 59.569 245.247
potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] Rooted 41.6879 Divided 1.43973 28.9554
ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157] Measured 20911 Subtracted 3997.5 24908.5
58 glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217] Ranked 185.678 59.569 245.247
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] 266.863 Divided 1.25979 336.191
kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559] Measured 1631.67 1.63302 2664.55
melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] Squared 219048 1.68808 129762
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] Rooted 137.446 Subtracted 16.623 120.823
potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] 41.6969 Divided 1.43933 28.9696
ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064] Measured 20911 Subtracted 3997.5 24908.5
retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246] Squared 173408 69581 242989
59 anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685] Measured 20911 3997.5 24908.5
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] Ranked 266.863 Divided 1.25978 336.19
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] Squared 219048 1.68808 129762
kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688] Measured 1631.67 1.63302 2664.55
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] Rooted 137.446 Subtracted 16.623 120.823
nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09] 37.2205 Divided 1.40262 52.2064
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] Ranked 269.278 Subtracted 58.431 327.709
serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873] Squared 199594 69573 130021
60 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] Measured 4489.19 Divided 1.6231 2765.82
cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929] Ranked 269.254 Subtracted 58.401 327.655
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] 266.864 Divided 1.25976 336.184
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] Squared 219048 1.68808 129762
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] Rooted 137.446 Subtracted 16.623 120.823
protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] Squared 192904 66737 126167
son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583] Rooted 35.6294 Divided 1.39806 49.8119
ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] Measured 16771.5 Subtracted 3882.4 12889.1
61 beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121] 6475.5 3832 10307.5
glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216] 4489.19 Divided 1.6231 2765.82
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] Ranked 266.864 1.25975 336.182
kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] Rooted 43.4291 1.36932 31.7159
melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] 137.446 Subtracted 16.623 120.823
necdin. [swissprot;acc:q99608] Squared 219048 Divided 1.68808 129762
potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980] Ranked 269.248 Subtracted 58.394 327.642
type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210] Squared 192779 66684 126095
62 beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407] Measured 6475.5 3832 10307.5
glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737] 4489.19 Divided 1.6231 2765.82
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] Ranked 266.865 1.25974 336.181
melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] Rooted 137.446 Subtracted 16.623 120.823
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] Squared 219048 Divided 1.68808 129762
potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] Rooted 43.4519 1.36847 31.7522
potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979] Ranked 269.23 Subtracted 58.371 327.601
ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050] Squared 189976 65496 124480
63 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] Ranked 266.865 Divided 1.25973 336.178
kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] Rooted 43.4554 1.36835 31.7576
melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363] 137.446 Subtracted 16.623 120.823
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] Squared 219048 Divided 1.68808 129762

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/