Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene Rank Value Type description Network Comparison Type Interaction Map green Filtered red network_comparison

Results: HTML CSV LaTeX

Showing element 425 to 474 of 29840 in total

Interaction Map

: High confidence

Rank	Value Type	description	Network Comparison Type	green	Filtered	red	network_comparison
27	Squared	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	Subtracted	159204	0	151156	8048
		melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Subtracted	129762	1	219048	89286
		neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	Divided	457.521	1	143.692	3.18404
		syntaxin 10 (syn10). [swissprot;acc:o60499]	Divided	0.109658	0	4.29982	39.2112
	Rooted	60s ribosomal protein l37a. [swissprot;acc:p12751]	Subtracted	3.80565		13.7805	9.97485
		dystrophin. [swissprot;acc:p11532]	Divided	5.12693		17.8026	3.47237
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Divided	24.2968	1	40.3364	1.66015
		myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Subtracted	167.046	1	146.94	20.106
28	Measured	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	Divided	139	0	570	4.10072
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Divided	895.194	1	1834.36	2.04912
		necdin. [swissprot;acc:q99608]	Subtracted	18263	1	23693.7	5430.7
		spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6]		4543.75	0	5418.2	874.45
	Ranked	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]		18499.2	0	12941.7	5557.5
		cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	Divided	153.671	1	201.949	1.31416
		guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Subtracted	336.077	1	267.136	68.941
		p28 ing5. [refseq;acc:nm_032329]	Divided	7562.05	0	12124.8	1.60337
	Squared	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Subtracted	129762	1	219048	89286
		microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	Subtracted	159204	0	151156	8048
		neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	Divided	457.521	1	143.692	3.18404
		ptd016 protein. [refseq;acc:nm_016125]	Divided	5.90864	0	0.213018	27.7377
	Rooted	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Subtracted	3.80565	0	13.7805	9.97485
		gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Subtracted	129.699	1	149.165	19.466
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Divided	24.3043	1	40.3372	1.65967
		syntaxin 10 (syn10). [swissprot;acc:o60499]		3.64637	0	9.62443	2.63946
29	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]		895.507	1	1834.52	2.04858
		melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Subtracted	18263	1	23693.7	5430.7
		potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided	434.911	0	111.278	3.90833
		regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]	Subtracted	2399.76		3248.95	849.19
	Ranked	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]		8257		13730.5	5473.5
		guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]		336.075	1	267.139	68.936
		phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086]	Divided	11625	0	7395	1.57201
		uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]		243.678	1	187.458	1.29991
	Squared	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]		457.521	1	143.692	3.18404
		galectin-4 (lactose-binding lectin 4) (l-36 lactose binding protein) (l36lbp) (antigen ny-co-27). [swissprot;acc:p56470]	Subtracted	64272.5	0	72128.6	7856.1
		melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Subtracted	129762	1	219048	89286
		potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Divided	141.427	0	5.18438	27.2794
	Rooted	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	Subtracted	1.80368		11.3774	9.57372
		microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	Divided	7.34614		17.7955	2.42243
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided	43.1914	1	26.0288	1.65937
		putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted	192.165	1	210.928	18.763
30	Measured	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	Subtracted	4102.97	0	3265.25	837.72
		dystrophin. [swissprot;acc:p11532]	Divided	111.739	0	427.217	3.82335
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Divided	895.633	1	1834.59	2.04837
		melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	18263	1	23693.7	5430.7
	Ranked	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	Divided	11625	0	7395	1.57201
		guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Subtracted	336.075	1	267.14	68.935
		lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	Subtracted	8257	0	13730.5	5473.5
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Divided	243.678	1	187.457	1.29991
	Squared	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]		457.521	1	143.692	3.18404
	Squared	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]		141.944	0	6.25494	22.6931

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/