Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Value Type Network Comparison Type Gene Rank description green Interaction Map Filtered network_comparison red
Results: HTML CSV LaTeX Showing element 425 to 474 of 7460 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Rank
description
green
Filtered
network_comparison
red
213 pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388] 186.95 1 1.127 210.693
protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237] 8436.39 0 1.11179 9379.47
214 lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075] 170.192 1 1.12605 191.644
probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879] 8473.85 0 1.11176 7621.99
215 myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533] 126 1 1.125 112
myosin vi. [swissprot;acc:q9um54] 11250.5 0 1.11154 10121.5
216 maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708] 11732 1.11102 10559.7
myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623] 126 1 1.125 112
217 baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392] 6406.18 0 1.10858 7101.79
myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535] 126 1 1.125 112
218 lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 17469.2 0 1.10795 19355
myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2] 126 1 1.125 112
219 myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040] 11009.7 0 1.10777 12196.2
220 myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882] 126 1 1.125 112
neurocalcin delta. [swissprot;acc:p29554] 15473.5 0 1.10734 13973.6
221 estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 13497.2 1.10721 12190.3
myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883] 126 1 1.125 112
222 40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174] 11013.2 0 1.10622 12183
dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430] 126 1 1.125 112
223 myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]
pnas-18. [sptrembl;acc:q9bzu3] 13939.6 0 1.10608 12602.7
224 atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031] 8889.93 1.10413 9815.6
oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348] 165.623 1 1.12285 185.969
225 40s ribosomal protein s29. [swissprot;acc:p30054] 9997.71 0 1.10378 11035.3
small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330] 201.769 1 1.12243 226.471
226 cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747] 269.238 1.12187 239.991
rab gdp dissociation inhibitor alpha (rab gdi alpha) (gdi-1) (xap-4) (oligophrenin 2). [swissprot;acc:p31150] 16992.9 0 1.10374 15395.7
227 thrombospondin 3 precursor. [swissprot;acc:p49746] 269.234 1 1.12186 239.99
tigger transposable element derived 6. [refseq;acc:nm_030953] 11200.2 0 1.10355 12360
228 sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 202.088 1 1.12036 226.411
soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825] 11370.4 0 1.10355 10303.5
229 breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567] 202.094 1 1.12028 226.401
poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631] 9878.1 0 1.10339 10899.4
230 cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291] 267.915 1 1.11934 239.35
tigger transposable element derived 7; jerky (mouse) homolog-like. [refseq;acc:nm_033208] 11207.7 0 1.10323 12364.7
231 likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745] 267.881 1 1.11927 239.336
tigger transposable element derived 1; jerky (mouse) homolog-like. [refseq;acc:nm_145702] 11207.9 0 1.10322 12364.8
232 kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719] 11240.2 1.10271 12394.7
smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527] 267.879 1 1.11926 239.336
233 60s acidic ribosomal protein p1. [swissprot;acc:p05386] 10560 0 1.1015 9586.97
lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461] 267.842 1 1.11918 239.32
234 chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0] 256.835 1.11905 287.41
transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884] 18296 0 1.10124 16614
235 elongation factor 1-alpha 1 (ef-1-alpha-1) (elongation factor 1 a-1) (eef1a-1) (elongation factor tu) (ef-tu). [swissprot;acc:p04720] 16027.9 1.10123 14554.5
phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439] 254.15 1 1.11785 227.357
236 pp3111 protein. [refseq;acc:nm_022156]
protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 16788.5 0 1.10122 15245.4
237 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340] 9067 1.10114 9984
syntaxin 18. [swissprot;acc:q9p2w9] 254.15 1 1.11785 227.357

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/