Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Value Type Hugo description Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 4108 to 4157 of 12912 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
Value Type
Hugo
description
red
green
network_comparison
1027 Rooted CYC1 cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574] 52.1219 49.5013 1.05294
1028 Measured QPRT nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274] 5704 6241.36 1.09421
Ranked SUCLA2 succinyl-coa ligase [adp-forming] beta-chain, mitochondrial precursor (ec 6.2.1.5) (succinyl-coa synthetase, betaa chain) (scs-betaa) (atp- specific succinyl-coa synthetase beta subunit). [swissprot;acc:q9p2r7] 211.908 218.627 1.03171
Squared AIP ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170] 22126.7 25398.5 1.14787
Rooted ARHGAP26 oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1] 52.1219 49.5013 1.05294
1029 Measured CTNNB1 beta-catenin (pro2286). [swissprot;acc:p35222] 5635.26 6166.09 1.0942
Ranked DDB1 dna damage binding protein 1 (damage-specific dna binding protein 1) (ddb p127 subunit) (ddba) (uv-damaged dna-binding protein 1) (uv-ddb 1) (xeroderma pigmentosum group e complementing protein) (xpce) (x- associated protein 1) (xap-1). [swissprot;acc:q16531] 222.364 215.535 1.03168
Squared FTHL17 ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8] 31999.3 36726.8 1.14774
Rooted RGN senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493] 52.1219 49.5013 1.05294
1030 Measured no value casein kinase i, epsilon isoform (ec 2.7.1.-) (cki-epsilon) (ckie). [swissprot;acc:p49674] 5048.33 5523.85 1.09419
Ranked PCCB propionyl-coa carboxylase beta chain, mitochondrial precursor (ec 6.4.1.3) (pccase beta subunit) (propanoyl-coa:carbon dioxide ligase beta subunit). [swissprot;acc:p05166] 222.364 215.535 1.03168
Squared FTMT mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478] 31994.3 36720 1.1477
Rooted OPHN1 oligophrenin 1. [swissprot;acc:o60890] 52.1219 49.5013 1.05294
1031 Measured FAM57A membrane protein expressed in epithelial-like lung adenocarcinoma. [refseq;acc:nm_024792] 6136.99 6714.98 1.09418
Ranked EMG1 probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979] 242.978 235.518 1.03167
Squared CREG2 cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836] 31994 36719.6 1.1477
Rooted no value kappa b-ras 1. [refseq;acc:nm_020345] 61.2289 64.4564 1.05271
1032 Measured IPO11 ran binding protein 11. [refseq;acc:nm_016338] 6138.91 6717.05 1.09418
Ranked AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120] 186.664 180.943 1.03162
Squared no value dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6] 31994 36719.6 1.1477
Rooted NKIRAS2 i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595] 61.2289 64.4564 1.05271
1033 Measured FBP2 fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757] 6080.91 6653.52 1.09417
Ranked TYR tyrosinase precursor (ec 1.14.18.1) (monophenol monooxygenase) (tumor rejection antigen ab) (sk29-ab) (lb24-ab). [swissprot;acc:p14679] 221.183 214.406 1.03161
Squared DLGAP1 disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490] 31994 36719.6 1.1477
Rooted SNAPAP snare associated protein snapin. [refseq;acc:nm_012437] 61.2289 64.4564 1.05271
1034 Measured MAT1A s-adenosylmethionine synthetase alpha and beta forms (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-i/iii). [swissprot;acc:q00266] 6152.88 6732.12 1.09414
Ranked ESRRB steroid hormone receptor err2 (estrogen-related receptor, beta) (err-beta) (estrogen receptor-like 2) (err beta-2). [swissprot;acc:o95718] 186.551 180.837 1.0316
Squared AHCYL1 putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865] 31994 36719.6 1.1477
Rooted DCP1A transcription factor smif; decapping enzyme hdcp1a. [refseq;acc:nm_018403] 58.8683 61.9622 1.05256
1035 Measured CSNK1D casein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid). [swissprot;acc:p48730] 5054.73 5530.23 1.09407
Ranked MAGI2 atrophin-1 interacting protein 1; activin receptor interacting protein 1; likely ortholog of mouse activin receptor interacting protein 1; atrophin-1 interacting protein a; membrane associated guanylate kinase 2; activin receptor interacting p. [refseq;acc:nm_012301] 221.682 228.68 1.03157
Squared KIAA0430 limkain b1. [refseq;acc:nm_019081] 31994 36719.6 1.1477
Rooted RPUSD2 c18b11 homolog (44.9kd). [refseq;acc:nm_152260] 60.6801 63.8644 1.05248
1036 Measured FBP1 fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467] 6077.65 6649.22 1.09404
Ranked COPB1 coatomer beta subunit (beta-coat protein) (beta-cop). [swissprot;acc:p53618] 171.341 176.746 1.03155
Squared no value putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2] 31994 36719.6 1.1477
Rooted TMBIM4 z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24] 60.6801 63.8644 1.05248
1037 Measured MGLL monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283] 6544.26 7159.43 1.094
Ranked GLRX3 thioredoxin-like; pkc-interacting cousin of thioredoxin. [refseq;acc:nm_006541] 228.412 235.609 1.03151
Squared CREG1 cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851] 31994 36719.6 1.1477
Rooted TMBIM1 pp1201 protein. [refseq;acc:nm_022152] 60.6801 63.8644 1.05248
1038 Measured MYB myb proto-oncogene protein (c-myb). [swissprot;acc:p10242] 5417.95 5924.41 1.09348
Ranked no value 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943] 186.741 181.041 1.03148
Squared DLGAP3 disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886] 31994 36719.6 1.1477
Rooted FAIM2 lifeguard; kiaa0950 protein. [refseq;acc:nm_012306] 60.6801 63.8644 1.05248
1039 Measured MYBL2 myb-related protein b (b-myb). [swissprot;acc:p10244] 5418.92 5923.09 1.09304
Ranked DLD dihydrolipoamide dehydrogenase, mitochondrial precursor (ec 1.8.1.4) (glycine cleavage system l protein). [swissprot;acc:p09622] 207.719 214.236 1.03137
Squared KNG1 kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042] 31994 36719.6 1.1477
Rooted no value sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772] 60.6801 63.8644 1.05248
1040 Measured RBM39 rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498] 5421.93 5926.08 1.09298

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/