Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 4080 to 4129 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
red
green
network_comparison
2040 tbc1 domain family protein c22orf4-like (fragment). [swissprot;acc:q9nu19] Subtracted 218.79 216.981 1.809
2041 ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131] Divided 196.808 195.141 1.00854
tbc1 domain family protein c22orf4. [swissprot;acc:q8wua7] Subtracted 218.79 216.981 1.809
2042 electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134] 199.092 197.301 1.791
t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806] Divided 210.586 208.803 1.00854
2043 brachyury protein (t protein). [swissprot;acc:o15178] Subtracted 1.783
ubiquilin 1 isoform 1. [refseq;acc:nm_013438] Divided 196.837 195.173 1.00853
2044 adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203] 199.928 198.24 1.00851
t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806] Subtracted 210.586 208.803 1.783
2045 huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146] 189.052 190.835
ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4] Divided 199.928 198.24 1.00851
2046 adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]
cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493] Subtracted 221.703 223.483 1.78
2047 peptidyl-prolyl cis-trans isomerase nima-interacting 1 (ec 5.2.1.8) (rotamase pin1) (ppiase pin1). [swissprot;acc:q13526]
solute carrier family 2, facilitated glucose transporter, member 6 (glucose transporter type 6) (glucose transporter type 9). [swissprot;acc:q9ugq3] Divided 224.124 226.003 1.00838
2048 iroquois-class homeodomain protein irx-4 (iroquois homeobox protein 4). [swissprot;acc:p78413] Subtracted 221.703 223.483 1.78
solute carrier family 2, facilitated glucose transporter, member 8 (glucose transporter type 8) (glucose transporter type x1). [swissprot;acc:q9ny64] Divided 224.124 226.003 1.00838
2049 goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4] Subtracted 189.011 190.787 1.776
translation initiation factor eif-2b beta subunit (eif-2b gdp-gtp exchange factor) (s20i15) (s20iii15). [swissprot;acc:p49770] Divided 220.787 222.634 1.00837
2050 huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291] Subtracted 188.961 190.73 1.769
sh3 domain-binding glutamic acid-rich protein (sh3bgr protein) (21- glutamic acid-rich protein) (21-garp). [swissprot;acc:p55822] Divided 218.79 216.981 1.00834
2051 oxidation resistance 1. [refseq;acc:nm_181354]
ubiquitin-conjugating enzyme e2 n (ec 6.3.2.19) (ubiquitin-protein ligase n) (ubiquitin carrier protein n) (ubc13) (bendless-like ubiquitin conjugating enzyme). [swissprot;acc:q16781] Subtracted 214.328 212.561 1.767
2052 ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977] Divided 207.667 205.95 1.00834
tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814] Subtracted 193.517 191.766 1.751
2053 lats, large tumor suppressor, homolog 2; lats (large tumor suppressor, drosophila) homolog 2. [refseq;acc:nm_014572] Divided 218.79 216.981 1.00834
putative acyl-coa thioester hydrolase cgi-16 (ec 3.1.2.-). [swissprot;acc:q9y305] Subtracted 193.517 191.766 1.751
2054 dead-box protein. [refseq;acc:nm_018665]
ornithine decarboxylase-like protein (ec 4.1.1.17) (odc-paralogue) (odc-p). [swissprot;acc:q96a70] Divided 207.665 205.948 1.00834
2055 dual specificity mitogen-activated protein kinase kinase 1 (ec 2.7.1.-) (map kinase kinase 1) (mapkk 1) (erk activator kinase 1) (mapk/erk kinase 1) (mek1). [swissprot;acc:q02750] Subtracted 217.555 215.807 1.748
dymeclin. [refseq;acc:nm_017653] Divided 218.79 216.981 1.00834
2056 sh3 domain-binding glutamic acid-rich-like protein. [swissprot;acc:o75368]
similar to kinase suppressor of ras (fragment). [sptrembl;acc:q8ivt5] Subtracted 217.555 215.807 1.748
2057 dual specificity mitogen-activated protein kinase kinase 2 (ec 2.7.1.-) (map kinase kinase 2) (mapkk 2) (erk activator kinase 2) (mapk/erk kinase 2) (mek2). [swissprot;acc:p36507]
lats homolog 1. [refseq;acc:nm_004690] Divided 218.79 216.981 1.00834
2058 glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (ec 2.6.1.16) (hexosephosphate aminotransferase 1) (d-fructose-6- phosphate amidotransferase 1) (gfat 1) (gfat1). [swissprot;acc:q06210] Subtracted 222.548 224.293 1.745
sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5] Divided 218.79 216.981 1.00834
2059 isocitrate dehydrogenase [nad] subunit alpha, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p50213] Subtracted 222.58 224.32 1.74
nuclear receptor coactivator 7; estrogen receptor associated protein 140 kda. [refseq;acc:nm_181782] Divided 218.79 216.981 1.00834
2060 dj132f21.2 (contains a novel protein similar to the l82e from drosophila) (fragment). [sptrembl;acc:q9h125]
isocitrate dehydrogenase [nad] subunit beta, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:o43837] Subtracted 222.58 224.32 1.74
2061 isocitrate dehydrogenase [nad] subunit gamma, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad+-specific icdh). [swissprot;acc:p51553]
tbc1 domain family protein c22orf4-like (fragment). [swissprot;acc:q9nu19] Divided 218.79 216.981 1.00834
2062 polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999] Subtracted 229.266 227.53 1.736
tbc1 domain family protein c22orf4. [swissprot;acc:q8wua7] Divided 218.79 216.981 1.00834
2063 glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (ec 2.6.1.16) (hexosephosphate aminotransferase 2) (d-fructose-6- phosphate amidotransferase 2) (gfat 2) (gfat2). [swissprot;acc:o94808] Subtracted 222.609 224.344 1.735
ornithine decarboxylase (ec 4.1.1.17) (odc). [swissprot;acc:p11926] Divided 207.638 205.923 1.00833
2064 aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763] 207.655 205.939
dna polymerase gamma subunit 1 (ec 2.7.7.7) (mitochondrial dna polymerase catalytic subunit) (polg-alpha). [swissprot;acc:p54098] Subtracted 216.324 214.599 1.725
2065 ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977] 207.667 205.95 1.717

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/