Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison

Results: HTML CSV LaTeX

Showing element 94 to 143 of 3730 in total

Value Type	Ranked
Network Comparison Type	Divided
Interaction Map	High confidence

Rank	description	Filtered	red	green	network_comparison	
47	gbp protein isoform a. [source:refseq;acc:nm_017870]	1	325.586	256.492	1.26938	
48	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [source:refseq;acc:nm_007278]	1	65.4586	83.0461	1.26868	
48	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [source:swissprot;acc:q16718]	0	9830	6909	1.42278	
49	beta-arrestin 2 (arrestin, beta 2). [source:swissprot;acc:p32121]	1	133	105	1.26667	
49	brain protein 16. [source:refseq;acc:nm_016458]	0	6890.54	4854.99	1.41927	
50	beta-arrestin 1 (arrestin, beta 1). [source:swissprot;acc:p49407]	1	133	105	1.26667	
50	cartilage oligomeric matrix protein precursor (comp). [source:swissprot;acc:p49747]	0	9249.73	13091.4	1.41533	
51	importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [source:swissprot;acc:p52292]	0	7168	5102	1.40494	
51	spermatogenesis associated 6. [source:refseq;acc:nm_019073]	1	133	105	1.26667	
52	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [source:swissprot;acc:q01433]	1	133	105	1.26667	
52	ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [source:swissprot;acc:o95376]	0	3284	4554.5	1.38688	
53	transcription factor jun-b. [source:swissprot;acc:p17275]	1	201.144	158.868	1.26611	
53	ubiquitin-conjugating enzyme e2-18 kda ubch7 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (ubcm4) (e2-f1) (l-ubc). [source:swissprot;acc:p51966]	0	3284	4554.5	1.38688	
54	syntaxin 10 (syn10). [source:swissprot;acc:o60499]	0	13884.4	19014.6	1.36949	
54	transcription factor jun-d. [source:swissprot;acc:p17535]	1	200.941	158.941	1.26425	
55	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [source:refseq;acc:nm_003690]	1	320.927	254.434	1.26134	
55	sedlin. [source:swissprot;acc:o14582]	0	22440	16388	1.36929	
56	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [source:swissprot;acc:o60262]	1	266.856	336.233	1.25998	
56	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [source:swissprot;acc:q9y296]	0	22440	16388	1.36929	
57	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [source:swissprot;acc:q9ubi6]	1	266.856	336.233	1.25998	
57	hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [source:swissprot;acc:q16543]	0	8152.55	11134.8	1.36581	
58	dead-box protein. [source:refseq;acc:nm_018665]	0	10628.3	14486	1.36296	
58	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [source:swissprot;acc:p50150]	1	266.863	336.191	1.25979	
59	glutamate dehydrogenase 2, mitochondrial precursor (ec 1.4.1.3) (gdh). [source:swissprot;acc:p49448]	0	15863.6	11662.3	1.36025	
59	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [source:swissprot;acc:p29798]	1	266.863	336.19	1.25978	
60	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [source:swissprot;acc:p46926]	0	11761	15924	1.35397	
60	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [source:swissprot;acc:q9uk08]	1	266.864	336.184	1.25976	
61	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [source:swissprot;acc:p30670]	1	266.864	336.182	1.25975	
61	testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [source:swissprot;acc:p16562]	0	15352	11346.5	1.35302	
62	glycine receptor alpha-3 chain precursor. [source:swissprot;acc:o75311]	0	9418.7	12695.6	1.34791	
62	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [source:swissprot;acc:p50151]	1	266.865	336.181	1.25974	
63	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [source:swissprot;acc:q9y3k8]	1	266.865	336.178	1.25973	
63	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [source:swissprot;acc:p46977]	0	8519.83	11453	1.34428	
64	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [source:swissprot;acc:p50152]	1	266.868	336.159	1.25965	
64	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [source:refseq;acc:nm_032517]	0	15264	20387	1.33563	
65	e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [source:refseq;acc:nm_015409]	0	7853.67	10406.3	1.32502	
65	guanine nucleotide-binding protein g(q), alpha subunit. [source:swissprot;acc:p50148]	1	267.136	336.077	1.25807	
66	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [source:swissprot;acc:p29992]	1	267.136	336.077	1.25807	
66	heparan sulfate 6-o-sulfotransferase 2. [source:refseq;acc:nm_147174]	0	11461	15180	1.32449	
67	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [source:swissprot;acc:p19087]	1	267.14	336.075	1.25805	
67	presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [source:refseq;acc:nm_172341]	0	10793.5	14291.5	1.32408	
68	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [source:swissprot;acc:p19086]	1	267.139	336.075	1.25805	
68	purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [source:swissprot;acc:p00491]	0	8932.56	11823.3	1.32362	
69	collagen alpha 5(iv) chain precursor. [source:swissprot;acc:p29400]	0	7704.7	10174.1	1.32051	
69	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [source:swissprot;acc:p11488]	1	267.14	336.075	1.25805	
70	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04899]	1	267.142	336.074	1.25804	
70	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [source:refseq;acc:nm_003981]	0	13975.7	10593.2	1.31931	
71	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04898]	1	267.144	336.073	1.25802	
71	nucleoporin nup43 (p42). [source:swissprot;acc:q8nfh3]	0	4338.65	5700.79	1.31395	
72	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [source:swissprot;acc:p08754]	1	267.144	336.073	1.25802	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/