Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 3808 to 3857 of 6456 in total
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
red
green
network_comparison
1904 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase). [refseq;acc:nm_003679] Subtracted 6952.66 7315.06 362.4
1905 son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890] Divided 7497.96 7967.09 1.06257
squalene monooxygenase (ec 1.14.99.7) (squalene epoxidase) (se). [swissprot;acc:q14534] Subtracted 6952.66 7315.06 362.4
1906 lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776] 5068.17 5430.41 362.24
mitochondrial ribosomal protein l18. [refseq;acc:nm_014161] Divided 5396.61 5733.93 1.06251
1907 arp2/3 complex 34 kda subunit (p34-arc) (actin-related protein 2/3 complex subunit 2). [swissprot;acc:o15144] Subtracted 5384.89 5746.51 361.62
hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934] Divided 6858.84 7287.27 1.06246
1908 28s ribosomal protein s26, mitochondrial precursor (mrp-s26) (mrp- s13). [swissprot;acc:q9byn8] Subtracted 6437.24 6797.24 360
dc11 protein. [refseq;acc:nm_020186] Divided 6858.84 7287.27 1.06246
1909 amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]
enhancer of rudimentary homolog. [swissprot;acc:q14259] Subtracted 6437.24 6797.24 360
1910 5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [swissprot;acc:p22557] Divided 6858.84 7287.27 1.06246
translation initiation factor eif-2b beta subunit (eif-2b gdp-gtp exchange factor) (s20i15) (s20iii15). [swissprot;acc:p49770] Subtracted 5456.57 5816.14 359.57
1911 brain protein 16. [refseq;acc:nm_016458] 5774.02 6133.01 358.99
ubiquitin-activating enzyme e1c (uba3 homolog, yeast); ubiquitin-activating enzyme e1c (homologous to yeast uba3). [refseq;acc:nm_003968] Divided 6858.84 7287.27 1.06246
1912 dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6] Subtracted 5386.37 5744.89 358.52
ubiquitin-activating enzyme e1 (a1s9 protein). [swissprot;acc:p22314] Divided 6858.84 7287.27 1.06246
1913 calcium-binding mitochondrial carrier protein aralar1 (solute carrier family 25, member 12). [swissprot;acc:o75746]
zinc finger protein 258. [refseq;acc:nm_145310] Subtracted 5386.37 5744.89 358.52
1914 melanoma antigen recognized by t cells 2. [refseq;acc:nm_018194] Divided 6858.84 7287.27 1.06246
zinc finger protein 261 (dxs6673e protein). [swissprot;acc:q14202] Subtracted 5386.37 5744.89 358.52
1915 5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196] Divided 6858.84 7287.27 1.06246
zinc finger protein 262; cell death inhibiting rna. [refseq;acc:nm_005095] Subtracted 5386.37 5744.89 358.52
1916 actin-like protein 2 (actin-related protein 2). [swissprot;acc:o15142]
calcium-binding mitochondrial carrier protein aralar2 (solute carrier family 25, member 13) (citrin). [swissprot;acc:q9ujs0] Divided 6858.84 7287.27 1.06246
1917 acyl carrier protein, mitochondrial precursor (acp) (nadh-ubiquinone oxidoreductase 9.6 kda subunit) (ci-sdap). [swissprot;acc:o14561]
conserved oligomeric golgi complex component 3 (vesicle docking protein sec34 homolog) (p94). [swissprot;acc:q96jb2] Subtracted 5386.37 5744.89 358.52
1918 seven in absentia homolog 1. [refseq;acc:nm_003031] Divided 5394.24 5730.73 1.06238
similar to actin-related protein 3-beta. [sptrembl;acc:q96bt2] Subtracted 5386.37 5744.89 358.52
1919 arp2/3 complex 41 kda subunit (p41-arc) (actin-related protein 2/3 complex subunit 1b). [swissprot;acc:o15143]
hydroxyindole o-methyltransferase (ec 2.1.1.4) (hiomt) (acetylserotonin o-methyltransferase) (asmt). [swissprot;acc:p46597] Divided 5444.6 5783.95 1.06233
1920 basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811] 6262.66 6652.85 1.0623
zinc finger protein 198 (fused in myeloproliferative disorders protein) (rearranged in atypical myeloproliferative disorder protein). [swissprot;acc:q9ubw7] Subtracted 5386.37 5744.89 358.52
1921 actin-like protein 3 (actin-related protein 3) (actin-2). [swissprot;acc:p32391]
salivary proline-rich protein po (allele k) [contains: peptide p-d] (fragment). [swissprot;acc:p10162] Divided 6262.66 6652.85 1.0623
1922 arp2/3 complex 21 kda subunit (p21-arc) (actin-related protein 2/3 complex subunit 3). [swissprot;acc:o15145] Subtracted 5386.37 5744.89 358.52
hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543] Divided 5567.41 5914.05 1.06226
1923 brain protein 16. [refseq;acc:nm_016458] 5774.02 6133.01 1.06217
nardilysin precursor (ec 3.4.24.61) (n-arginine dibasic convertase) (nrd convertase) (nrd-c). [swissprot;acc:o43847] Subtracted 5386.37 5744.89 358.52
1924 actin-related protein 2/3 complex subunit 1a (sop2-like protein). [swissprot;acc:q92747]
transcriptional adaptor 3-like isoform a. [refseq;acc:nm_006354] Divided 7260.23 7711.3 1.06213
1925 bromodomain containing 7; bromodomain protein; bromodomain-containing 7. [refseq;acc:nm_013263] 7711.29
interferon-related developmental regulator 2 (skmc15 protein). [swissprot;acc:q12894] Subtracted 5386.48 5744.78 358.3
1926 arp2/3 complex 16 kda subunit (p16-arc) (actin-related protein 2/3 complex subunit 5). [swissprot;acc:o15511] 5386.49 5744.76 358.27
frg1 protein (fshd region gene 1 protein). [swissprot;acc:q14331] Divided 7260.23 7711.3 1.06213
1927 coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579] Subtracted 8493.7 8135.59 358.11
transcriptional adapter 2-like (ada2-like protein) (kl04p). [swissprot;acc:o75478] Divided 7260.23 7711.3 1.06213
1928 glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292] Subtracted 5888.32 6245.89 357.57
son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889] Divided 7514.8 7980.22 1.06193
1929 fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519] Subtracted 5888.32 6245.89 357.57

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/