MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	Rank	network_comparison	Interaction Map	red	description	green	Filtered

Results: HTML CSV LaTeX

Showing element 368 to 417 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	red	description	green
368	1.17261	5082.66	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	5959.99
369	1.17061	3583.56	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	4194.95
370	1.17058	4108.15	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	4808.93
371	1.16961	5067.02	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	5926.46
372	1.16956	5067	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	5926.17
373	1.16955	5066.99	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	5926.1
374	1.16942	5066.93	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	5925.38
375	1.16854	4700.42	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	5492.63
376	1.16769	17385.9	44050 protein. [refseq;acc:nm_178832]	14889.2
377			nuclear inhibitor of protein phosphatase-1 (nipp-1) (protein phosphatase 1, regulatory inhibitor subunit 8) [includes: activator of rna decay (ec 3.1.4.-) (ard-1)]. [swissprot;acc:q12972]
378	1.16758	12471.7	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	14561.7
379	1.16512	6704.44	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	7811.45
380	1.16461	12998.5	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	15138.2
381	1.16456	5246.01	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	6109.31
382	1.16447	4533.74	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]	5279.4
383			hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]
384			cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]
385			pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]
386			60s ribosomal protein l8. [swissprot;acc:p25120]
387			hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]
388			pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]
389			probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]
390			rw1 protein (fragment). [swissprot;acc:q92545]
391	1.16358	3658.76	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	3144.39
392	1.16339	3641.89	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	4236.95
393	1.16301	4490.28	eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]	5222.25
394			bai1-associated protein 3; bai-associated protein 3. [refseq;acc:nm_003933]
395	1.16251	4532.73	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	5269.33
396	1.16205	6563.65	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	7627.29
397	1.16137	5367.04	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	6233.12
398	1.16125	5084.26	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	5904.1
399	1.16109	5201.41	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	4479.76
400			adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]
401			adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]
402			leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]
403			fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]
404			leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]
405			laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]
406			thymic stromal co-transporter. [refseq;acc:nm_033051]
407	1.16071	6603.41	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	7664.65
408	1.1604	6102.59	dok-like protein. [refseq;acc:nm_024872]	7081.46
409			docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]
410			docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]
411			tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]
412	1.16015	3594.31	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	4169.95
413	1.15994	6644.99	vav proto-oncogene. [swissprot;acc:p15498]	7707.8
414	1.15974	6744.05	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	5815.13
415	1.15927	6647.43	vav-3 protein. [swissprot;acc:q9ukw4]	7706.18
416	1.15842	4509.54	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	5223.95
417	1.15708	4522.71	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	5233.14

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.