MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	red	network_comparison	green
polybromo 1. [refseq;acc:nm_018165]	2052	5634.8	1.05642	5952.7
polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	2579	4979.44	1.01849	5071.53
polyhomeotic like 3; early development regulator 3; polyhomeotic 3. [refseq;acc:nm_024947]	2809	0.00001	1	0.00001
polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	283	5221.28	1.20935	6314.35
polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999]	765	4726.38	1.11268	5258.95
polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	2583	3926.4	1.01776	3857.88
polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	2630	3985.17	1.01446	3928.38
polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	1156	5840.77	1.08819	6355.89
polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	2531	6141.97	1.02428	6291.08
polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [refseq;acc:nm_004481]	2097	6024.47	1.05512	6356.56
polyposis locus protein 1 (tb2 protein). [swissprot;acc:q00765]	2611	6380.6	1.01498	6476.18
polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]	2613
polypyrimidine tract binding protein 2; neural polypyrimidine tract binding protein; ptb-like protein. [refseq;acc:nm_021190]	2281	5783.73	1.04585	6048.91
polypyrimidine tract-binding protein 1 (ptb) (heterogeneous nuclear ribonucleoprotein i) (hnrnp i) (57 kda rna-binding protein pptb-1). [swissprot;acc:p26599]	2293	5783.76		6048.94
ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	448	6259.3	1.14884	7190.91
porphobilinogen deaminase (ec 4.3.1.8) (hydroxymethylbilane synthase) (hmbs) (pre-uroporphyrinogen synthase) (pbg-d). [swissprot;acc:p08397]	1202	4913.07	1.08648	5337.95
possible global transcription activator snf2l1. [swissprot;acc:p28370]	2055	5634.8	1.05642	5952.7
possible global transcription activator snf2l2 (snf2-alpha). [swissprot;acc:p51531]	2057
possible global transcription activator snf2l4 (snf2-beta) (brg-1 protein) (mitotic growth and transcription activator) (brahma protein homolog 1). [swissprot;acc:p51532]	2054
postsynaptic protein cript; hspc139 protein. [refseq;acc:nm_014171]	3034	0.00001	1	0.00001
potassium channel modulatory factor 1; potassium channel modulatory factor; differentially expressed in branching tubulogenesis 91; zinc finger, zz domain containing 1. [refseq;acc:nm_020122]	1816	5633.44	1.06454	5997
potassium channel tetramerisation domain containing 3; ny-ren-45 antigen. [refseq;acc:nm_016121]	2975	0.00001	1	0.00001
potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	139	2759.61	1.31442	2099.49
potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	2188	6682.7	1.05022	7018.29
potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	2176	6674.58	1.05114	7015.93
potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	2196	6688.64	1.04954	7020.02
potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	91	2416.53	1.42082	1700.8
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	88	2411.93	1.42259	1695.45
potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	90	2414.77	1.4215	1698.75
potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	720	6593.17	1.117	7364.55
potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	716
potential phospholipid-transporting atpase ih (ec 3.6.3.1) (atpase class i type 11a) (atpase is). [swissprot;acc:p98196]	1349	6153.36	1.07921	6640.77
potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	1453	5602.01	1.07659	6031.05
pp1201 protein. [refseq;acc:nm_022152]	709	5317.78	1.11781	5944.25
pp3111 protein. [refseq;acc:nm_022156]	1964	4374.32	1.05994	4126.96
pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	2559	5291.65	1.02002	5187.78
pre-b-cell leukemia transcription factor 4. [refseq;acc:nm_025245]	2473	7765.3	1.03074	8004
pre-b-cell leukemia transcription factor-1 (homeobox protein pbx1) (homeobox protein prl). [swissprot;acc:p40424]	2466
pre-b-cell leukemia transcription factor-2 (homeobox protein pbx2) (g17 protein). [swissprot;acc:p40425]	2472
pre-b-cell leukemia transcription factor-3 (homeobox protein pbx3). [swissprot;acc:p40426]	2467
pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	554	14830.5	1.13641	13050.3
pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	331	20287.2	1.18751	17083.8
pre-mrna cleavage factor i, 59 kda subunit. [refseq;acc:nm_024811]	1942	5805.06	1.06083	6158.16
pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	304	4855.46	1.19958	5824.52
pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	368	5082.66	1.17261	5959.99
prefoldin subunit 1. [swissprot;acc:o60925]	1554	5875.75	1.07267	6302.76
prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	1073	5207.39	1.09214	5687.2
prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	1072
prefoldin subunit 4 (protein c-1). [swissprot;acc:q9nqp4]	3130	0.00001	1	0.00001
prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	911	4982.81	1.09996	5480.91

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.