MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 351 to 400 of 66312 in total

Filtered  : 1

Rank	description	Value Type	Network Comparison Type	Interaction Map	red	green	network_comparison
22	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Squared	Divided	High confidence	108.641	823.69	7.58176
	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]		Subtracted	Low confidence	122475	159767	37292
23	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Ranked	Divided	High confidence	58	44	1.31818
	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Measured		Low confidence	40899	32028.5	1.27696
	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		Subtracted		2399.5	543.5	1856
	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	Rooted	Divided		63.2736	76.7316	1.2127
	gbp protein isoform a. [refseq;acc:nm_017870]	Measured		High confidence	699.76	1894.39	2.7072
	glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335]	Ranked	Subtracted	Low confidence	247.202	282.937	35.735
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Rooted	Divided	High confidence	40.3358	24.2919	1.66046
	implantation-associated protein. [refseq;acc:nm_032121]	Ranked		Low confidence	198	163	1.21472
		Rooted	Subtracted		57.2538	71.1231	13.8693
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Measured		High confidence	23693.7	18263	5430.7
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Squared			219048	129762	89286
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Ranked			322	253	69
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Rooted			153.578	133.176	20.402
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Squared	Divided	Low confidence	78998	57169.1	1.38183
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]			High confidence	143.692	457.521	3.18404
	vasodilator-stimulated phosphoprotein (vasp). [swissprot;acc:p50552]		Subtracted	Low confidence	97360.9	72915.2	24445.7
24	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	Measured	Divided		5720.25	4577.5	1.24965
	bcl2-related ovarian killer. [refseq;acc:nm_032515]	Rooted			50.6099	61.2591	1.21042
	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Measured	Subtracted		2399.5	543.5	1856
	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	Squared	Divided	High confidence	143.692	457.521	3.18404
	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	Rooted	Subtracted	Low confidence	63.2736	76.7316	13.458
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]			High confidence	153.548	133.153	20.395
	ena/vasodilator stimulated phosphoprotein-like protein (ena/vasp-like protein). [swissprot;acc:q9ui08]	Squared		Low confidence	97360.9	72915.2	24445.7
	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Ranked			247.202	282.937	35.735
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Rooted	Divided	High confidence	40.336	24.2941	1.66032
	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	Ranked		Low confidence	188.298	228.509	1.21355
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Measured	Subtracted	High confidence	23693.7	18263	5430.7
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Squared			219048	129762	89286
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]		Divided	Low confidence	78977.2	57161.1	1.38166
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Ranked		High confidence	58	44	1.31818
	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Measured			950.561	2108.52	2.21818
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Ranked	Subtracted		322	253	69
25	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]		Divided	Low confidence	286.396	238.476	1.20094
	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Squared	Subtracted		80340.8	57685.7	22655.1
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		Divided		77316.3	56522.1	1.3679
	doc-1 related protein (doc-1r). [swissprot;acc:o75956]			High confidence	143.692	457.521	3.18404
	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Ranked	Subtracted		322	253	69
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Rooted	Divided		40.3361	24.295	1.66026
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	Measured			1833.01	892.67	2.0534
	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]			Low confidence	5847.46	4691.96	1.24627
		Rooted			67.7094	56.875	1.19049
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Measured	Subtracted		2399.5	543.5	1856
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Squared		High confidence	219048	129762	89286
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Measured			23693.7	18263	5430.7
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Rooted			146.94	167.046	20.106
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Ranked	Divided		58	44	1.31818
	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]		Subtracted	Low confidence	198	163	35
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Rooted			53.5555	66.8994	13.3439

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.