MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	Rank	network_comparison	Interaction Map	red	description	green	Filtered

Results: HTML CSV LaTeX

Showing element 325 to 374 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	red	description	green
325	1.18899	16177.9	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	19235.4
326	1.18883	3432.96	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]	4081.21
327	1.18839	16067.4	septin 10 isoform 1. [refseq;acc:nm_144710]	19094.4
328	1.18801	15999.1	brain protein 44. [swissprot;acc:o95563]	19007.1
329			septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]
330	1.1878	15959.9	septin 6. [swissprot;acc:q14141]	18957.1
331	1.18751	20287.2	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	17083.8
332	1.183	5051.16	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	5975.51
333	1.18299	5039.63	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	5961.83
334	1.18298	14924.4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	17655.2
335	1.18181	3494.31	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	4129.6
336	1.18128	3751.3	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	4431.34
337	1.18049	20446.1	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	24136.4
338			homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]
339			homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]
340			homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]
341			homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]
342			homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]
343			homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]
344			homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]
345			retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]
346	1.17931	14229.2	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	16780.7
347	1.17914	4991.02	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	5885.09
348			splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]
349	1.17806	4714.85	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	5554.38
350	1.17745	17396.9	sedlin. [swissprot;acc:o14582]	20483.9
351			synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]
352			bet3 homolog. [swissprot;acc:o43617]
353	1.17669	12839	p66 alpha. [refseq;acc:nm_017660]	10911.1
354			transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]
355			tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]
356	1.1763	11004.2	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	12944.2
357	1.17567	5061.11	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	5950.22
358			microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]
359	1.17559	12798.9	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	10887.2
360	1.17553	12796.8	g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	10886
361	1.17528	12787.6	cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]	10880.5
362	1.17525	12786.6	g2/mitotic-specific cyclin b1. [swissprot;acc:p14635]	10879.9
363	1.17509	12780.7	cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493]	10876.4
364	1.17334	5189	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	6088.47
365			calcyphosine. [swissprot;acc:q13938]
366			crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]
367	1.17268	4024.4	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	4719.35
368	1.17261	5082.66	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	5959.99
369	1.17061	3583.56	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	4194.95
370	1.17058	4108.15	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	4808.93
371	1.16961	5067.02	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	5926.46
372	1.16956	5067	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	5926.17
373	1.16955	5066.99	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	5926.1
374	1.16942	5066.93	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	5925.38

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.