MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3051 to 3100 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1526	cadherin-related tumor suppressor homolog precursor (fat protein homolog). [swissprot;acc:q14517]	Divided	219.306	223.179	1.01766
	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	Subtracted	213.267	209.511	3.756
1527	mln64 n-terminal domain homolog (stard3 n-terminal like protein). [swissprot;acc:o95772]	Divided	219.306	223.179	1.01766
	seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]	Subtracted	213.267	209.511	3.756
1528	af-6 protein. [swissprot;acc:p55196]		218.733	214.98	3.753
	hepatocyte nuclear factor 3-gamma (hnf-3g) (forkhead box protein a3) (fork head-related protein fkh h3). [swissprot;acc:p55318]	Divided	217.785	214.021	1.01759
1529	actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571]		216.762	213.031	1.01751
	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	Subtracted	222.672	218.92	3.752
1530	af-6 protein. [swissprot;acc:p55196]	Divided	218.733	214.98	1.01746
	m-phase inducer phosphatase 2 (ec 3.1.3.48) (dual specificity phosphatase cdc25b). [swissprot;acc:p30305]	Subtracted	260.269	256.531	3.738
1531	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	Divided	217.025	213.304	1.01744
	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]	Subtracted	225.159	221.424	3.735
1532	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]
	rna-binding protein 10 (rna binding motif protein 10) (dxs8237e). [swissprot;acc:p98175]	Divided	228.419	232.376	1.01732
1533	adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	Subtracted	225.159	221.424	3.735
	cytochrome c. [swissprot;acc:p00001]	Divided	228.419	232.376	1.01732
1534	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]
	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]	Subtracted	213.259	209.524	3.735
1535	adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]		225.159	221.424
	heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]	Divided	228.419	232.376	1.01732
1536	actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571]	Subtracted	216.762	213.031	3.731
	fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	Divided	228.419	232.376	1.01732
1537	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	Subtracted	217.025	213.304	3.721
	ww domain binding protein 11; npw38-binding protein npwbp; sh3 domain-binding protein snp70. [refseq;acc:nm_016312]	Divided	228.419	232.376	1.01732
1538	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]
	myb-related protein b (b-myb). [swissprot;acc:p10244]	Subtracted	222.541	218.823	3.718
1539	myb-related protein a (a-myb). [swissprot;acc:p10243]		222.512	218.802	3.71
	rna-binding protein 5 (rna binding motif protein 5) (putative tumor suppressor luca15) (g15 protein). [swissprot;acc:p52756]	Divided	228.419	232.376	1.01732
1540	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	Subtracted	217.769	221.474	3.705
	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Divided	240.077	236.015	1.01721
1541	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	Subtracted	192.336	188.637	3.699
	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	Divided	222.672	218.92	1.01714
1542	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	Subtracted	219.762	216.081	3.681
	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	Divided	213.546	209.965	1.01706
1543	gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]
	orphan nuclear receptor tr2. [swissprot;acc:p13056]	Subtracted	219.76	216.083	3.677
1544	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	Divided	219.762	216.081	1.01704
	thymidylate synthase (ec 2.1.1.45) (ts) (tsase). [swissprot;acc:p04818]	Subtracted	225.119	228.769	3.65
1545	dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374]
	orphan nuclear receptor tr2. [swissprot;acc:p13056]	Divided	219.76	216.083	1.01702
1546	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]		217.769	221.474	1.01701
	stromal cell-derived factor 2 precursor (sdf-2). [swissprot;acc:q99470]	Subtracted	225.119	228.769	3.65
1547	myb-related protein b (b-myb). [swissprot;acc:p10244]	Divided	222.541	218.823	1.01699
	stromal cell-derived factor 2-like protein 1 precursor (sdf2 like protein 1) (pwp1-interacting protein 8). [swissprot;acc:q9hcn8]	Subtracted	225.119	228.769	3.65
1548	eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5]		221.128	224.767	3.639
	myb-related protein a (a-myb). [swissprot;acc:p10243]	Divided	222.512	218.802	1.01696
1549	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]		225.159	221.424	1.01687
	erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	Subtracted	221.128	224.767	3.639
1550	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	Divided	225.159	221.424	1.01687
	bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [refseq;acc:nm_176824]	Subtracted	221.128	224.767	3.639

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.