Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 275 to 324 of 6456 in total 
Value Type	Measured
Interaction Map	High confidence
Filtered	1

Rank	description	Network Comparison Type	red	green	network_comparison	
138	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [source:refseq;acc:nm_014592]	Divided	2755.15	2094.3	1.31555	
138	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [source:swissprot;acc:q13625]	Subtracted	15182.5	13277.9	1904.6	
139	cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [source:swissprot;acc:p06493]	Subtracted	12780.7	10876.4	1904.3	
139	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [source:refseq;acc:nm_147183]	Divided	2759.61	2099.49	1.31442	
140	homeobox protein hlx1 (homeobox protein hb24). [source:swissprot;acc:q14774]	Subtracted	2597.5	698.5	1899	
140	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [source:refseq;acc:nm_173193]	Divided	2760.28	2100.27	1.31425	
141	hbs1-like. [source:refseq;acc:nm_006620]	Subtracted	2597.5	698.5	1899	
141	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [source:swissprot;acc:p43330]	Divided	4405.4	5782.08	1.3125	
142	metalloprotease 1; metalloprotease 1 (pitrilysin family). [source:refseq;acc:nm_014889]	Divided	9276.47	7090.37	1.30832	
142	transcription factor jun-d. [source:swissprot;acc:p17535]	Subtracted	5638.2	7523.39	1885.19	
143	beta-1,4 mannosyltransferase. [source:refseq;acc:nm_019109]	Divided	9275.1	7089.65	1.30826	
143	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [source:swissprot;acc:p33240]	Subtracted	15427.2	13572.8	1854.4	
144	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [source:swissprot;acc:p31483]	Subtracted	4133.47	5945.32	1811.85	
144	sad1/unc-84 protein-like 1. [source:swissprot;acc:o94901]	Divided	3349.9	4362.61	1.30231	
145	nucleolysin tiar (tia-1 related protein). [source:swissprot;acc:q01085]	Subtracted	4136.36	5943.56	1807.2	
145	ubiquitin activating enzyme e1-like protein. [source:refseq;acc:nm_006395]	Divided	16771.5	12889.1	1.30122	
146	associated molecule with the sh3 domain of stam (amsh) like protein. [source:refseq;acc:nm_020799]	Divided	11068	8508.5	1.30082	
146	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [source:refseq;acc:nm_007266]	Subtracted	2671	871	1800	
147	protein x 0004. [source:refseq;acc:nm_016301]	Subtracted	2671	871	1800	
147	putative breast adenocarcinoma marker (32kd). [source:refseq;acc:nm_014453]	Divided	11068	8508.5	1.30082	
148	associated molecule with the sh3 domain of stam. [source:refseq;acc:nm_006463]	Divided	11068	8508.5	1.30082	
148	symplekin. [source:swissprot;acc:q92797]	Subtracted	15213.4	13418.1	1795.3	
149	neuroendocrine differentiation factor; comparative gene identification transcript 149. [source:refseq;acc:nm_016079]	Divided	11068	8508.5	1.30082	
149	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [source:swissprot;acc:o75648]	Subtracted	11736.6	13531.9	1795.3	
150	protein hspc134 (protein cda04). [source:swissprot;acc:q9by43]	Divided	11068	8508.5	1.30082	
150	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [source:swissprot;acc:p13641]	Subtracted	4172.91	5954.48	1781.57	
151	pre-mrna cleavage complex ii protein clp1. [source:swissprot;acc:q92989]	Subtracted	14830.5	13050.3	1780.2	
151	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [source:refseq;acc:nm_005489]	Divided	4578.09	5939.91	1.29746	
152	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [source:refseq;acc:nm_006339]	Subtracted	5136.78	6895.98	1759.2	
152	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [source:refseq;acc:nm_030801]	Divided	23693.7	18263	1.29736	
153	hepatocellular carcinoma-associated protein hca3. [source:refseq;acc:nm_138703]	Divided	23693.7	18263	1.29736	
153	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [source:swissprot;acc:p13533]	Subtracted	9035	7279.6	1755.4	
154	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [source:swissprot;acc:p43357]	Divided	23693.7	18263	1.29736	
154	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [source:swissprot;acc:q9y623]	Subtracted	9035	7279.6	1755.4	
155	melanoma-associated antigen 11 (mage-11 antigen). [source:swissprot;acc:p43364]	Divided	23693.7	18263	1.29736	
155	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [source:swissprot;acc:p13535]	Subtracted	9035	7279.6	1755.4	
156	melanoma-associated antigen 2 (mage-2 antigen). [source:swissprot;acc:p43356]	Divided	23693.7	18263	1.29736	
156	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [source:swissprot;acc:q9ukx2]	Subtracted	9035	7279.6	1755.4	
157	hepatocellular carcinoma-associated protein hca1. [source:refseq;acc:nm_020932]	Divided	23693.7	18263	1.29736	
157	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [source:swissprot;acc:p11055]	Subtracted	9035	7279.6	1755.4	
158	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [source:swissprot;acc:p43360]	Divided	23693.7	18263	1.29736	
158	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [source:swissprot;acc:p12882]	Subtracted	9035	7279.6	1755.4	
159	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [source:swissprot;acc:p12883]	Subtracted	9035	7279.6	1755.4	
159	necdin. [source:swissprot;acc:q99608]	Divided	23693.7	18263	1.29736	
160	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [source:sptrembl;acc:q9h430]	Subtracted	9035	7279.6	1755.4	
160	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [source:swissprot;acc:q9y5v3]	Divided	23693.7	18263	1.29736	
161	melanoma-associated antigen f1 (mage-f1 antigen). [source:swissprot;acc:q9hay2]	Divided	23693.7	18263	1.29736	
161	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [source:swissprot;acc:q9ukx3]	Subtracted	9035	7279.6	1755.4	
162	high-mobility group 20a. [source:refseq;acc:nm_018200]	Subtracted	5140.14	6893.53	1753.39	
162	melanoma antigen, family b, 6. [source:refseq;acc:nm_173523]	Divided	23693.7	18263	1.29736	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/