MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	red	green	Value Type	Rank	description	network_comparison	Interaction Map	Filtered

Results: HTML CSV LaTeX

Showing element 25776 to 25825 of 77072 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : Low confidence
Filtered  : 1

red	green	Rank	description	network_comparison
7899.2	8076.07	3991	q9h4t4 like. [refseq;acc:nm_080672]	1.02239
		3992	membrane-associated guanylate kinase-related 3. [refseq;acc:nm_152900]
7899.22	8164.34	1615	rhesus blood group-associated glycoprotein (erythrocyte plasma membrane 50 kda glycoprotein) (rh50a). [swissprot;acc:q02094]	1.03356
7900.14	8133.56	2692	fetal brain protein 239 (239fb). [swissprot;acc:q15777]	1.02955
7900.15	8113.67	3269	histone-lysine n-methyltransferase, h3 lysine-9 specific 4 (ec 2.1.1.43) (histone h3-k9 methyltransferase 4) (h3-k9-hmtase 4) (set domain bifurcated 1) (erg-associated protein with set domain) (eset). [swissprot;acc:q15047]	1.02703
		3271	quaking isoform 6. [sptrembl;acc:q9p0x9]
	8374.91	277	dual oxidase 2 precursor; dual oxidase-like domains 2; nicotinamide adenine dinucleotide phosphate oxidase; flavoprotein nadph oxidase; nadph thyroid oxidase 2; nadh/nadph thyroid oxidase p138-tox; nadph oxidase/peroxidase duox2. [refseq;acc:nm_014080]	1.0601
7900.16	8121.28	3006	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	1.02799
7900.36	8189.22	1169	nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345]	1.03656
7900.52	8095.84	3700	axin 2 (axis inhibition protein 2) (conductin) (axin-like protein) (axil). [swissprot;acc:q9y2t1]	1.02472
		3702	axin 1 (axis inhibition protein 1) (haxin). [swissprot;acc:o15169]
7900.62	8094.29	3728	3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	1.02451
7900.86	8168.2	1552	protein disulfide isomerase a2 precursor (ec 5.3.4.1) (pdip). [swissprot;acc:q13087]	1.03384
7900.92	8375.39	279	dual oxidase 1 precursor; nadph thyroid oxidase 1; flavoprotein nadph oxidase; nicotinamide adenine dinucleotide phosphate oxidase. [refseq;acc:nm_017434]	1.06005
7900.95	8146.23	2314	mitogen-activated protein kinase kinase kinase 7 interacting protein 2 isoform 1; tak1-binding protein 2. [refseq;acc:nm_015093]	1.03104
7900.97	8147.94	2257	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	1.03126
7901.16	8148.15	2254	ubiquitin. [swissprot;acc:p02248]
7901.74	7926.82	4962	homolog of rat nadrin; rhogap protein. [refseq;acc:nm_018054]	1.00317
7901.82	8148.33	2272	nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]	1.0312
7901.89	8135.5	2687	cdc45-related protein (porc-pi-1). [swissprot;acc:o75419]	1.02956
7902.1	8316.41	417	amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	1.05243
7902.5	8096.14	3731	lim domain only 7; zinc-finger domain-containing protein; lomp protein; f-box only protein 20; f-box protein fbx20. [refseq;acc:nm_005358]	1.0245
7902.9	8376.6	280	diacylglycerol o-acyltransferase 1 (ec 2.3.1.20) (diglyceride acyltransferase) (acat related gene product 1). [swissprot;acc:o75907]	1.05994
7903.17	8107.12	3533	bisphosphoglycerate mutase (ec 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (bpgm) (ec 5.4.2.1) (ec 3.1.3.13) (bpg-dependent pgam). [swissprot;acc:p07738]	1.02581
7903.24	8125.13	2991	mam domain containing glycosylphosphatidylinositol anchor 1; glycosyl-phosphatidyl-inositol-mam. [refseq;acc:nm_153487]	1.02808
7903.43	8128	2919	kinesin protein. [refseq;acc:nm_032559]	1.02841
7903.47	8127.82	2921	40s ribosomal protein s30. [swissprot;acc:q05472]	1.02839
7903.84	8154.56	2112	nad(p) dependent steroid dehydrogenase-like. [refseq;acc:nm_145168]	1.03172
		2119	nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231]
		2120	elks protein. [refseq;acc:nm_015064]
		2121	est1p-like protein a. [refseq;acc:nm_017575]
7904.14	8377.35	282	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	1.05987
7904.17	8377.37	284	nadph oxidase 3; nadph oxidase catalytic subunit-like 3. [refseq;acc:nm_015718]
7904.19	8377.38	281	cytochrome b-245 heavy chain (p22 phagocyte b-cytochrome) (neutrophil cytochrome b, 91 kda polypeptide) (cgd91-phox) (gp91-phox) (heme binding membrane glycoprotein gp91phox) (cytochrome b(558) beta chain) (superoxide-generating nadph oxidase heavy chain subunit). [swissprot;acc:p04839]
7904.2	8377.39	283	nadph oxidase 4. [refseq;acc:nm_016931]
		285	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]
7904.34	7927.66	4967	sh3-domain binding protein 1 (3bp-1). [swissprot;acc:q9y3l3]	1.00295
7904.53	8146.48	2423	cop9 subunit 6 (mov34 homolog, 34 kd). [refseq;acc:nm_006833]	1.03061
7904.83	8122.28	3139	calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8]	1.02751
7904.89	8122.34	3134	calcipressin 2 (thyroid hormone-responsive protein zaki-4) (down syndrome candidate region 1-like 1) (myocyte-enriched calcineurin interacting protein 2) (mcip2). [swissprot;acc:q14206]
	8148.92	2361	kelch-like ech-associated protein 1 (cytosolic inhibitor of nrf2). [swissprot;acc:q14145]	1.03087
7905.15	8111.8	3475	putatative 28 kda protein. [refseq;acc:nm_020143]	1.02614
7905.34	8122.79	3133	zinc finger protein zic 4 (zinc finger protein of the cerebellum 4) (fragment). [swissprot;acc:q8n9l1]	1.02751
		3135	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]
7905.37	8122.83	3132	dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2]
7905.38	8091.1	3875	sorting nexin 6 (traf4-associated factor 2). [swissprot;acc:q9unh7]	1.02349
7906.02	8119.58	3275	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	1.02701
7906.07	8168.77	1691	zinc finger homeobox protein 1b (smad interacting protein 1) (smadip1) (hrihfb2411). [swissprot;acc:o60315]	1.03323
		1692	transcription factor 8 (nil-2-a zinc finger protein) (negative regulator of il2). [swissprot;acc:p37275]
7906.09	8123.56	3136	calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805]	1.02751

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.