MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Network Comparison Type	Gene	description	Rank	Filtered	Interaction Map	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 258 to 307 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	red	green
alpha-actinin 4 (non-muscle alpha-actinin 4) (f-actin cross linking protein). [swissprot;acc:o43707]	1805	1.01178	217.008	214.482
alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [swissprot;acc:p42024]	1509	1.01795	225.148	221.177
alpha-fetoprotein enhancer binding protein (at motif-binding factor) (at-binding transcription factor 1). [swissprot;acc:q15911]	2255	1.00595	202.366	203.57
alpha-nac protein. [sptrembl;acc:q9h009]	889	1.03908	212.028	204.053
alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	1249	1.02437	219.354	224.7
alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	812	1.04425	212.386	221.785
alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]	1961	1.00978	211.633	213.703
alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]	1959
alveolar soft part sarcoma chromosome region, candidate 1; aspl protein; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17 gene; aspscr1/tfe3 fusion gene, included. [refseq;acc:nm_024083]	2829	1	0.00001	0.00001
amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	637	1.05957	228.639	242.258
aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	1420	1.02084	203.979	208.229
aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	2064	1.00833	207.655	205.939
aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	2544	1.00192	212.67	212.262
ammecr1 protein. [refseq;acc:nm_015365]	1577	1.01645	222.585	218.982
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	52	1.26667	133	105
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	139	1.20415	271.752	225.68
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	2490	1.00284	194.527	195.08
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	3191	1	0.00001	0.00001
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2636	1.00128	195.635	195.384
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	2663	1.00107	204.768	204.549
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	2679	1.00096	190.142	189.959
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	240	1.11785	227.357	254.15
angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]	2586	1.00154	213.422	213.75
angiomotin. [refseq;acc:nm_133265]	2585
anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	143	1.20408	59	49
ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]	2519	1.00234	215.835	216.341
ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]	2518
ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	805	1.04425	212.386	221.785
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	1088	1.0295	219.673	213.378
annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	1094	1.02938	219.655	213.385
antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	2418	1.00359	218.2	218.984
apg3p; pc3-96 protein. [refseq;acc:nm_022488]	169	1.18722	82.5916	98.0548
apical-like protein (apxl protein). [swissprot;acc:q13796]	362	1.09641	231.492	211.136
apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	248	1.11719	237.302	212.41
apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	1606	1.0159	207.916	204.662
apolipoprotein b-100 precursor (apo b-100) [contains: apolipoprotein b-48 (apo b-48)]. [swissprot;acc:p04114]	2151	1.00686	217.871	219.366
apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	1293	1.024	233.942	228.46
apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	1014	1.03238	243.045	235.422
apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	1132	1.02731	218.484	212.675
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	1111	1.02766	217.99	212.123
apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	2421	1.00359	210.205	209.454
apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; apex nuclease-like 2. [refseq;acc:nm_014481]	2531	1.00221	216.264	215.787
aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	2690	1.00077	188.191	188.046
aquaporin 5. [swissprot;acc:p55064]	2692		188.192	188.048
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	2691		188.193
aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	2694	1.00075	188.223	188.081
arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	1184	1.02586	216.729	222.334
arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	1110	1.02769	216.78	222.782
arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	947	1.03567	212.51	205.191
arginase 1 (ec 3.5.3.1) (liver-type arginase). [swissprot;acc:p05089]	1885	1.01064	204.44	206.615

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.