Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Network Comparison Type Value Type description Filtered Interaction Map network_comparison green red
Results: HTML CSV LaTeX Showing element 2551 to 2600 of 3228 in total 
Network Comparison Type	Divided
Value Type	Ranked
Filtered	1
Interaction Map	High confidence

Rank	description	network_comparison	green	red	
2551	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [source:swissprot;acc:o00757]	1.00182	210.148	209.766	
2552	testis-specific chromodomain y protein 1. [source:swissprot;acc:q9y6f8]	1.0018	193.467	193.12	
2553	chromodomain protein, y chromosome-like isoform a; cdy-like, autosomal; testis-specific chromodomain y-like protein. [source:refseq;acc:nm_004824]	1.0018	193.467	193.12	
2554	testis-specific chromodomain protein y protein 2. [source:swissprot;acc:q9y6f7]	1.0018	193.467	193.12	
2555	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [source:swissprot;acc:p31153]	1.00179	212.572	212.953	
2556	chromodomain y-like protein 2. [source:refseq;acc:nm_152342]	1.00177	193.46	193.119	
2557	elongation factor 2 (ef-2). [source:swissprot;acc:p13639]	1.00175	223.047	222.658	
2558	metabotropic glutamate receptor 2 precursor (mglur2). [source:swissprot;acc:q14416]	1.00175	223.047	222.658	
2559	metabotropic glutamate receptor 3 precursor (mglur3). [source:swissprot;acc:q14832]	1.00175	223.047	222.658	
2560	monoglyceride lipase; lysophospholipase-like. [source:refseq;acc:nm_007283]	1.00175	202.042	202.395	
2561	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [source:swissprot;acc:p09467]	1.00169	210.18	209.825	
2562	glycogenin-1 (ec 2.4.1.186). [source:swissprot;acc:p46976]	1.00168	208.779	208.429	
2563	adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [source:swissprot;acc:p55263]	1.00168	208.779	208.429	
2564	protein x 0001. [source:refseq;acc:nm_016302]	1.00168	208.779	208.429	
2565	glycogenin-2 (ec 2.4.1.186) (gn-2) (gn2). [source:swissprot;acc:o15488]	1.00168	208.779	208.429	
2566	serine/threonine protein kinase 12 (ec 2.7.1.37) (aurora- and ipl1- like midbody-associated protein 1) (aim-1) (aurora/ipl1-related kinase 2) (aurora-related kinase 2) (stk-1) (aurora-b). [source:swissprot;acc:q96gd4]	1.00164	220.267	219.907	
2567	kinesin-like protein kif23 (mitotic kinesin-like protein-1) (kinesin- like protein 5). [source:swissprot;acc:q02241]	1.00164	220.267	219.907	
2568	serine/threonine protein kinase 13 (ec 2.7.1.37) (aurora/ipl1/eg2 protein 2) (aurora/ipl1-related kinase 3) (aurora-c). [source:swissprot;acc:q9uqb9]	1.00164	220.267	219.907	
2569	serine/threonine kinase 6 (ec 2.7.1.37) (serine/threonine kinase 15) (aurora/ipl1-related kinase 1) (aurora-related kinase 1) (hark1) (aurora-a) (breast-tumor-amplified kinase). [source:swissprot;acc:o14965]	1.00164	220.267	219.907	
2570	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [source:refseq;acc:nm_015247]	1.00164	220.267	219.907	
2571	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [source:swissprot;acc:p18031]	1.00164	209.205	209.549	
2572	transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [source:swissprot;acc:q16514]	1.00163	204.285	203.953	
2573	peroxiredoxin 4 (ec 1.11.1.-) (prx-iv) (thioredoxin peroxidase ao372) (thioredoxin-dependent peroxide reductase a0372) (antioxidant enzyme aoe372) (aoe37-2). [source:swissprot;acc:q13162]	1.00161	213.005	213.347	
2574	swi/snf-related matrix-associated actin-dependent regulator of chromatin c1; mammalian chromatin remodeling complex brg1-associated factor 155; swi/snf complex 155 kda subunit; chromatin remodeling complex baf155 subunit. [source:refseq;acc:nm_003074]	1.00159	219.667	220.016	
2575	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [source:swissprot;acc:p17706]	1.00157	209.255	209.583	
2576	beta-1-syntrophin (59 kda dystrophin-associated protein a1, basic component 1) (dapa1b) (tax interaction protein 43) (tip-43) (syntrophin 2) (bsyn2). [source:swissprot;acc:q13884]	1.00154	213.75	213.422	
2577	ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; apyrase; soluble calcium-activated nucleotidase scan-1. [source:refseq;acc:nm_138793]	1.00154	192.922	192.625	
2578	beta-2-syntrophin (59 kda dystrophin-associated protein a1, basic component 2) (syntrophin 3) (snt3) (syntrophin-like) (sntl). [source:swissprot;acc:q13425]	1.00154	213.75	213.422	
2579	nitrilase 1. [source:refseq;acc:nm_005600]	1.00154	213.75	213.422	
2580	utrophin (dystrophin-related protein 1) (drp1) (drp). [source:swissprot;acc:p46939]	1.00154	213.75	213.422	
2581	dystrobrevin beta (beta-dystrobrevin) (dtn-b). [source:swissprot;acc:o60941]	1.00154	213.756	213.428	
2582	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (ec 2.3.1.-) (e2) (dihydrolipoamide branched chain transacylase) (bckad e2 subunit). [source:swissprot;acc:p11182]	1.00154	213.75	213.422	
2583	dystrobrevin alpha (dystrobrevin-alpha). [source:swissprot;acc:q9y4j8]	1.00154	213.743	213.415	
2584	dystrophin. [source:swissprot;acc:p11532]	1.00154	213.75	213.422	
2585	angiomotin. [source:refseq;acc:nm_133265]	1.00154	213.75	213.422	
2586	angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [source:refseq;acc:nm_016201]	1.00154	213.75	213.422	
2587	alpha-1-syntrophin (59 kda dystrophin-associated protein a1, acidic component 1) (pro-tgf-alpha cytoplasmic domain-interacting protein 1) (tacip1) (syntrophin 1). [source:swissprot;acc:q13424]	1.00154	213.75	213.422	
2588	60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [source:swissprot;acc:p10809]	1.00151	222.64	222.305	
2589	membrane protein expressed in epithelial-like lung adenocarcinoma. [source:refseq;acc:nm_024792]	1.0015	212.422	212.74	
2590	proteasome subunit alpha type 6 (ec 3.4.25.1) (proteasome iota chain) (macropain iota chain) (multicatalytic endopeptidase complex iota chain) (27 kda prosomal protein) (pros-27) (p27k). [source:swissprot;acc:p34062]	1.00148	214.287	214.605	
2591	polybromo 1. [source:refseq;acc:nm_018165]	1.00147	219.696	220.02	
2592	swi/snf-related matrix-associated actin-dependent regulator of chromatin a5; sucrose nonfermenting-like 5. [source:refseq;acc:nm_003601]	1.00147	219.696	220.02	
2593	possible global transcription activator snf2l4 (snf2-beta) (brg-1 protein) (mitotic growth and transcription activator) (brahma protein homolog 1). [source:swissprot;acc:p51532]	1.00147	219.696	220.02	
2594	possible global transcription activator snf2l1. [source:swissprot;acc:p28370]	1.00147	219.696	220.02	
2595	tbp-associated factor 172 (taf-172) (taf(ii)170). [source:swissprot;acc:o14981]	1.00147	219.696	220.02	
2596	possible global transcription activator snf2l2 (snf2-alpha). [source:swissprot;acc:p51531]	1.00147	219.696	220.02	
2597	ran binding protein 11. [source:refseq;acc:nm_016338]	1.00146	212.401	212.711	
2598	transcription initiation factor tfiid 100 kda subunit (tafii-100) (tafii100). [source:swissprot;acc:q15542]	1.00145	202.436	202.142	
2599	ba207c16.2 (fragment). [source:sptrembl;acc:q9nql7]	1.00142	211.361	211.662	
2600	interferon-related developmental regulator 2 (skmc15 protein). [source:swissprot;acc:q12894]	1.00141	225.193	224.877	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/