Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 2277 to 2326 of 6456 in total 
Value Type	Measured
Interaction Map	High confidence
Filtered	1

Rank	description	Network Comparison Type	red	green	network_comparison	
1139	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [source:refseq;acc:nm_152870]	Subtracted	5790.65	6303.92	513.27	
1139	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [source:swissprot;acc:p28329]	Divided	5790.66	6303.95	1.08864	
1140	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [source:swissprot;acc:q04984]	Subtracted	5790.65	6303.92	513.27	
1140	voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [source:swissprot;acc:q13303]	Divided	5790.65	6303.93	1.08864	
1141	aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [source:swissprot;acc:o43488]	Divided	5790.65	6303.93	1.08864	
1141	rab acceptor 1 (prenylated); prenylated rab acceptor 1. [source:refseq;acc:nm_006423]	Subtracted	5790.65	6303.92	513.27	
1142	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [source:swissprot;acc:p52294]	Divided	5789.07	6302.01	1.0886	
1142	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [source:swissprot;acc:q9y3b8]	Subtracted	5790.65	6303.92	513.27	
1143	cda11 protein. [source:refseq;acc:nm_032026]	Subtracted	5874.11	6387.23	513.12	
1143	homeobox protein engrailed-2 (hu-en-2). [source:swissprot;acc:p19622]	Divided	6281.21	6837.61	1.08858	
1144	cpg binding protein (protein containing phd finger and cxxc domain 1). [source:swissprot;acc:q9p0u4]	Divided	6281.21	6837.61	1.08858	
1144	transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [source:swissprot;acc:p51854]	Subtracted	6011.44	6524.55	513.11	
1145	40s ribosomal protein s30. [source:swissprot;acc:q05472]	Divided	5893.97	6416.07	1.08858	
1145	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [source:swissprot;acc:p52294]	Subtracted	5789.07	6302.01	512.94	
1146	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [source:refseq;acc:nm_013375]	Divided	6281.21	6837.61	1.08858	
1146	o-sialoglycoprotein endopeptidase. [source:refseq;acc:nm_017807]	Subtracted	5391.64	5903.72	512.08	
1147	cytokine-like nuclear factor n-pac. [source:refseq;acc:nm_032569]	Divided	6281.21	6837.61	1.08858	
1147	nemo-like kinase; likely ortholog of mouse nemo like kinase. [source:refseq;acc:nm_016231]	Subtracted	5832.13	6343.59	511.46	
1148	elks protein. [source:refseq;acc:nm_015064]	Subtracted	5832.13	6343.59	511.46	
1148	hect type e3 ubiquitin ligase. [source:refseq;acc:nm_015052]	Divided	6281.21	6837.61	1.08858	
1149	transducin-like enhancer protein 3 (esg3). [source:swissprot;acc:q04726]	Divided	6280.74	6837.01	1.08857	
1149	tyrosinase-related gene segment, exon 5 (fragment). [source:sptrembl;acc:q15677]	Subtracted	5997.24	6508.62	511.38	
1150	cytosolic nonspecific dipeptidase (glutamate carboxypeptidase-like protein 1). [source:swissprot;acc:q96kp4]	Subtracted	6207.57	6718.7	511.13	
1150	mstp028 protein. [source:refseq;acc:nm_031954]	Divided	5838.87	6355.06	1.08841	
1151	alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [source:swissprot;acc:p42024]	Divided	5322.74	5793.15	1.08838	
1151	dopachrome tautomerase precursor (ec 5.3.3.12) (dt) (dct) (dopachrome delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). [source:swissprot;acc:p40126]	Subtracted	5998.58	6509.65	511.07	
1152	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [source:swissprot;acc:p17643]	Subtracted	5998.69	6509.74	511.05	
1152	beta-centractin (actin-related protein 1b) (arp1b). [source:swissprot;acc:p42025]	Divided	5322.74	5793.15	1.08838	
1153	meiotic recombination protein dmc1/lim15 homolog. [source:swissprot;acc:q14565]	Subtracted	5913.73	6423.98	510.25	
1153	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [source:swissprot;acc:q12824]	Divided	5840.01	6355.56	1.08828	
1154	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [source:swissprot;acc:q13829]	Divided	5840.65	6355.84	1.08821	
1154	tyrosinase precursor (ec 1.14.18.1) (monophenol monooxygenase) (tumor rejection antigen ab) (sk29-ab) (lb24-ab). [source:swissprot;acc:p14679]	Subtracted	6004.54	6514.24	509.7	
1155	transducin-like enhancer protein 4. [source:swissprot;acc:q04727]	Divided	6270.67	6823.73	1.0882	
1155	ubiquitin-like protein smt3a. [source:swissprot;acc:p55854]	Subtracted	5826.34	6335.98	509.64	
1156	polymerase delta-interacting protein 1; tnfaip1-like. [source:refseq;acc:nm_178863]	Divided	5840.77	6355.89	1.08819	
1156	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [source:swissprot;acc:p55855]	Subtracted	5826.29	6335.93	509.64	
1157	acrc protein; putative nuclear protein. [source:refseq;acc:nm_052957]	Subtracted	5826.32	6335.95	509.63	
1157	serine hydroxymethyltransferase, cytosolic (ec 2.1.2.1) (serine methylase) (glycine hydroxymethyltransferase) (shmt). [source:swissprot;acc:p34896]	Divided	5418.33	5895.2	1.08801	
1158	delta-aminolevulinic acid dehydratase (ec 4.2.1.24) (porphobilinogen synthase) (aladh). [source:swissprot;acc:p13716]	Divided	5489.18	5972.09	1.08797	
1158	pinin, desmosome associated protein; pinin. [source:refseq;acc:nm_002687]	Subtracted	5973.95	6483.32	509.37	
1159	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [source:swissprot;acc:q13347]	Subtracted	3975.77	4485.05	509.28	
1159	kccr13l. [source:refseq;acc:nm_139179]	Divided	5538.8	6025.51	1.08787	
1160	dna repair protein rad51 homolog 1 (hrad51) (hsrad51). [source:swissprot;acc:q06609]	Divided	5538.8	6025.51	1.08787	
1160	trinucleotide repeat containing 15. [source:refseq;acc:nm_015575]	Subtracted	3975.77	4485.05	509.28	
1161	autoantigen ngp-1. [source:swissprot;acc:q13823]	Subtracted	3766.14	4274.79	508.65	
1161	n-acetyltransferase 5 (ec 2.3.1.-). [source:swissprot;acc:q9y6d2]	Divided	5315.76	5782.63	1.08783	
1162	chaperone-activity of bc1 complex-like, mitochondrial precursor (chaperone-abc1-like). [source:swissprot;acc:q8ni60]	Subtracted	5799.35	6305.95	506.6	
1162	nemo-like kinase; likely ortholog of mouse nemo like kinase. [source:refseq;acc:nm_016231]	Divided	5832.13	6343.59	1.0877	
1163	aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [source:refseq;acc:nm_052853]	Subtracted	5799.35	6305.95	506.6	
1163	elks protein. [source:refseq;acc:nm_015064]	Divided	5832.13	6343.59	1.0877	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/