Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 2275 to 2324 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
red
green
network_comparison
1138 cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569] Subtracted 219.399 213.784 5.615
vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543] Divided 218.484 212.675 1.02731
1139 ganglioside-induced differentiation-associated protein 1-like 1. [refseq;acc:nm_024034]
transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725] Subtracted 219.374 213.759 5.615
1140 dead (asp-glu-ala-asp) box polypeptide 39 isoform 1; nuclear rna helicase, decd variant of dead box family. [refseq;acc:nm_005804] Divided 218.484 212.675 1.02731
hect type e3 ubiquitin ligase. [refseq;acc:nm_015052] Subtracted 219.399 213.784 5.615
1141 ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972] Divided 218.484 212.675 1.02731
transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724] Subtracted 219.375 213.767 5.608
1142 arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7] 216.729 222.334 5.605
vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8] Divided 218.484 212.675 1.02731
1143 kinesin protein. [refseq;acc:nm_032559] Subtracted 224.858 219.264 5.594
secretory pathway component sec31b-1. [refseq;acc:nm_015490] Divided 218.484 212.675 1.02731
1144 septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236] Subtracted 135.844 130.259 5.585
vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12] Divided 218.484 212.675 1.02731
1145 ny-ren-62 antigen (fragment). [sptrembl;acc:q9y590] Subtracted 224.805 219.251 5.554
vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864] Divided 218.481 212.675 1.0273
1146 ubiquitin. [swissprot;acc:p02248] Subtracted 209.061 203.518 5.543
vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313] Divided 218.483 212.676 1.0273
1147 peroxisomal membrane protein pex14 (peroxin-14) (peroxisomal membrane anchor protein pex14) (pts1 receptor docking protein). [swissprot;acc:o75381] 208.651 203.109 1.02729
Subtracted 5.542
1148 signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240] 224.878 219.342 5.536
ubiquitin. [swissprot;acc:p02248] Divided 209.061 203.518 1.02724
1149 bystin. [swissprot;acc:q13895] 239.505 233.185 1.0271
kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139] Subtracted 224.764 219.241 5.523
1150 sorting nexin 1. [swissprot;acc:q13596] Divided 209.868 215.522 1.02694
vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449] Subtracted 218.186 212.672 5.514
1151 metaxin 1. [swissprot;acc:q13505] Divided 199.552 204.925 1.02693
sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167] Subtracted 218.186 212.672 5.514
1152 epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204] Divided 221.939 216.143 1.02682
golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735] Subtracted 218.186 212.672 5.514
1153 delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929] Divided 221.93 216.146 1.02676
1154 cellular modulator of immune recognition. [refseq;acc:nm_145021] Subtracted 218.186 212.672 5.514
inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181] Divided 224.307 230.242 1.02646
1155 inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]
vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437] Subtracted 218.186 212.672 5.514
1156 aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9] Divided 224.307 230.242 1.02646
gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326] Subtracted 218.186 212.672 5.514
1157 ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170] Divided 224.307 230.242 1.02646
upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517] Subtracted 220.742 215.237 5.505
1158 epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772] Divided 221.877 216.167 1.02641
transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653] Subtracted 220.742 215.237 5.505
1159 lbp-9. [refseq;acc:nm_014553]
proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903] Divided 170.28 165.898 1.02641
1160 2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218] 208.55 214.041 1.02633
splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152] Subtracted 220.742 215.237 5.505
1161 adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559] 218.402 212.904 5.498
kappa b-ras 1. [refseq;acc:nm_020345] Divided 220.758 215.097 1.02632
1162 i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]
vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953] Subtracted 218.402 212.904 5.498

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/