Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 2101 to 2150 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
red
green
network_comparison
1051 17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034] Divided 211.449 217.998 1.03097
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995] Subtracted 219.673 213.378 6.295
1052 lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046] 220.291 226.584 6.293
retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725] Divided 211.449 217.998 1.03097
1053 annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073] Subtracted 219.655 213.385 6.27
proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066] Divided 207.04 200.84 1.03087
1054 60s ribosomal protein l21. [swissprot;acc:p46778] 223.958 217.263 1.03082
proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066] Subtracted 207.04 200.84 6.2
1055 hcv ns3-transactivated protein 1. [refseq;acc:nm_019048] Divided 219.01 212.468 1.03079
hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0] Subtracted 138.705 132.538 6.167
1056 methyltransferase like 2. [refseq;acc:nm_018396] 147.211 153.371 6.16
vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606] Divided 219.01 212.468 1.03079
1057 asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]
cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763] Subtracted 147.211 153.371 6.16
1058 ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245] Divided 228.105 221.293 1.03078
fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263] Subtracted 147.211 153.371 6.16
1059 ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973] Divided 228.105 221.293 1.03078
proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824] Subtracted 147.211 153.371 6.16
1060 nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231] Divided 218.162 211.648 1.03078
septin 6. [swissprot;acc:q14141] Subtracted 126.604 120.463 6.141
1061 adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2] 217.323 211.185 6.138
elks protein. [refseq;acc:nm_015064] Divided 218.162 211.648 1.03078
1062 brain protein 44. [swissprot;acc:o95563] Subtracted 126.215 120.078 6.137
zinc finger protein 174 (aw-1). [swissprot;acc:q15697] Divided 269.963 278.239 1.03066
1063 septin 7 (cdc10 protein homolog). [swissprot;acc:q16181] Subtracted 126.215 120.078 6.137
zinc finger imprinted 2. [swissprot;acc:q9nzv7] Divided 269.96 278.232 1.03064
1064 adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677] Subtracted 217.315 211.183 6.132
zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028] Divided 269.955 278.221 1.03062
1065 septin 10 isoform 1. [refseq;acc:nm_144710] Subtracted 125.526 119.402 6.124
zinc finger protein 305. [swissprot;acc:o43309] Divided 269.954 278.219 1.03062
1066 septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599] Subtracted 124.434 118.318 6.116
zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022] Divided 269.956 278.223 1.03062
1067 mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620] Subtracted 213.552 207.463 6.089
zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58] Divided 269.956 278.223 1.03062
1068 nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9] Subtracted 212.345 206.339 6.006
zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6] Divided 269.953 278.215 1.03061
1069 candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822] Subtracted 229.243 235.246 6.003
zinc finger protein 232. [swissprot;acc:q9uny5] Divided 269.954 278.218 1.03061
1070 arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161] Subtracted 216.78 222.782 6.002
zinc finger protein 99. [refseq;acc:nm_032164] Divided 269.954 278.218 1.03061
1071 dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0] 231.277 238.356
u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566] Subtracted 241.496 235.508 5.988
1072 inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181] 224.307 230.242 5.935
zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771] Divided 269.954 278.217 1.03061
1073 inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869] Subtracted 224.307 230.242 5.935
ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9] Divided 216.901 210.485 1.03048
1074 aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9] Subtracted 224.307 230.242 5.935
coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606] Divided 174.387 179.697 1.03045
1075 ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170] Subtracted 224.307 230.242 5.935
coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678] Divided 174.387 179.697 1.03045

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/