Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Value Type Network Comparison Type description Interaction Map red Filtered green network_comparison
Results: HTML CSV LaTeX Showing element 2101 to 2150 of 6456 in total
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
Network Comparison Type
description
red
green
network_comparison
1051 Divided homeobox protein dlx-2. [swissprot;acc:q07687] 4757.46 5198.91 1.09279
Subtracted signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240] 5208.27 5737.17 528.9
1052 Divided homeobox protein dlx-5. [swissprot;acc:p56178] 4757.46 5198.91 1.09279
Subtracted protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031] 6278.76 6807.51 528.75
1053 Divided fetal brain protein 239 (239fb). [swissprot;acc:q15777] 4757.46 5198.91 1.09279
Subtracted peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570] 5166.04 5694.55 528.51
1054 Divided homeobox protein dlx-3. [swissprot;acc:o60479] 4757.46 5198.91 1.09279
Subtracted heat shock factor binding protein 1. [swissprot;acc:o75506] 5915.42 6443.77 528.35
1055 Divided activated p21cdc42hs kinase. [refseq;acc:nm_005781] 4757.46 5198.91 1.09279
Subtracted mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352] 5167.15 5695.44 528.29
1056 Divided mitogen-activated protein kinase kinase kinase 7 interacting protein 2 isoform 1; tak1-binding protein 2. [refseq;acc:nm_015093] 4757.46 5198.91 1.09279
Subtracted xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736] 6413.32 6941.48 528.16
1057 Divided tata element modulatory factor (tmf). [swissprot;acc:p82094] 5412.23 5913.4 1.0926
Subtracted mitochondrial translational release factor 1-like. [refseq;acc:nm_019041] 5168.01 5696.12 528.11
1058 Divided scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680] 5412.23 5913.4 1.0926
Subtracted protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706] 6275.86 6803.95 528.09
1059 Divided tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814] 5719.01 6248.6 1.0926
Subtracted tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886] 3853.64 4379.71 526.07
1060 Divided putative acyl-coa thioester hydrolase cgi-16 (ec 3.1.2.-). [swissprot;acc:q9y305] 5719.01 6248.6 1.0926
Subtracted polyadenylate-binding protein 3 (poly(a)-binding protein 3) (pabp 3) (testis-specific poly(a)-binding protein). [swissprot;acc:q9h361] 5791.05 6316.61 525.56
1061 Divided nuclear pore complex protein nup98 (nucleoporin nup98) (98 kda nucleoporin). [swissprot;acc:p52948] 5412.23 5913.4 1.0926
Subtracted hskin17 protein. [refseq;acc:nm_012311] 5791.05 6316.61 525.56
1062 Divided ammecr1 protein. [refseq;acc:nm_015365] 5412.23 5913.4 1.0926
Subtracted carnitine o-acetyltransferase (ec 2.3.1.7) (carnitine acetylase) (cat). [swissprot;acc:p43155] 5791.05 6316.61 525.56
1063 Divided mrna-associated protein mrnp 41 (rae1 protein homolog). [swissprot;acc:p78406] 5412.23 5913.4 1.0926
Subtracted polyadenylate-binding protein 4 (poly(a)-binding protein 4) (pabp 4) (inducible poly(a)-binding protein) (ipabp) (activated-platelet protein-1) (app-1). [swissprot;acc:q13310] 5791.05 6316.61 525.56
1064 Divided dead-box protein. [refseq;acc:nm_018665] 5719.01 6248.6 1.0926
Subtracted polyadenylate-binding protein 1 (poly(a)-binding protein 1) (pabp 1). [swissprot;acc:p11940] 5791.05 6316.61 525.56
1065 Divided dna-(apurinic or apyrimidinic site) lyase (ec 4.2.99.18) (ap endonuclease 1) (apex nuclease) (apen) (ref-1 protein). [swissprot;acc:p27695] 6393.81 6984.94 1.09245
Subtracted dehydrodolichyl diphosphate synthase. [refseq;acc:nm_024887] 6350.81 6874.88 524.07
1066 Divided leucyl-trna synthetase. [refseq;acc:nm_020117] 5417.06 5917.79 1.09244
Subtracted junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923] 5732.73 6256.63 523.9
1067 Divided probable leucyl-trna synthetase, mitochondrial precursor (ec 6.1.1.4) (leucine--trna ligase) (leurs). [swissprot;acc:q15031] 5417.07 5917.79 1.09243
Subtracted tax interaction protein 1. [refseq;acc:nm_014604] 5732.73 6256.63 523.9
1068 Divided exocyst complex component sec15a. [swissprot;acc:q8tag9] 6201.54 6774.35 1.09237
Subtracted argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424] 5857.48 6380.4 522.92
1069 Divided elongation factor 2 (ef-2). [swissprot;acc:p13639] 5494.73 6001.08 1.09215
Subtracted glutamate carboxypeptidase-like protein 2 precursor. [swissprot;acc:q96kn2] 6251.32 6774.12 522.8
1070 Divided metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416] 5494.73 6001.08 1.09215
Subtracted thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919] 6042.31 6565.03 522.72
1071 Divided metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832] 5494.73 6001.08 1.09215
Subtracted 40s ribosomal protein s30. [swissprot;acc:q05472] 5893.97 6416.07 522.1
1072 Divided prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765] 5207.39 5687.2 1.09214
Subtracted electron transfer flavoprotein beta-subunit (beta-etf). [swissprot;acc:p38117] 7794.41 8316.04 521.63
1073 Divided prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9] 5207.39 5687.2 1.09214
Subtracted dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326] 5364.3 5885.48 521.18
1074 Divided uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9] 5207.39 5687.2 1.09214
Subtracted putative dimethylaniline monooxygenase [n-oxide forming] 6 (ec 1.14.13.8) (flavin-containing monooxygenase 6) (fmo 6) (dimethylaniline oxidase 6). [swissprot;acc:o60774] 5364.3 5885.48 521.18
1075 Divided phosphatidate cytidylyltransferase 1 (ec 2.7.7.41) (cdp-diglyceride synthetase 1) (cdp-diglyceride pyrophosphorylase 1) (cdp- diacylglycerol synthase 1) (cds 1) (ctp:phosphatidate cytidylyltransferase 1) (cdp-dag synthase 1) (cdp-dg synthetase 1). [swissprot;acc:q92903] 6441.56 7034.86 1.09211
Subtracted eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884] 4359.82 4880.99 521.17

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/