Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank description Network Comparison Type Value Type Interaction Map Filtered green red network_comparison
Results: HTML CSV LaTeX Showing element 2075 to 2124 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
green
red
network_comparison
1038 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943] Divided 181.041 186.741 1.03148
elks protein. [refseq;acc:nm_015064] Subtracted 211.648 218.162 6.514
1039 dihydrolipoamide dehydrogenase, mitochondrial precursor (ec 1.8.1.4) (glycine cleavage system l protein). [swissprot;acc:p09622] Divided 214.236 207.719 1.03137
phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613] Subtracted 213.685 220.118 6.433
1040 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]
t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643] Divided 168.359 163.24 1.03136
1041 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213] Subtracted 213.685 220.118 6.433
heterogeneous nuclear ribonucleoprotein l (hnrnp l). [swissprot;acc:p14866] Divided 181.099 186.774 1.03134
1042 estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 181.127 186.799 1.03132
ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9] Subtracted 210.485 216.901 6.416
1043 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7] Divided 182.137 187.834 1.03128
nucleolar protein nop5 (nucleolar protein 5) (nop58) (hspc120). [swissprot;acc:q9y2x3] Subtracted 232.837 239.219 6.382
1044 activator of camp-responsive element modulator (crem) in testis; lim protein act. [refseq;acc:nm_020482] 275.531 269.157 6.374
t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808] Divided 178.889 173.475 1.03121
1045 cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520] Subtracted 199.266 205.632 6.366
fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917] Divided 119.432 115.817 1.03121
1046 double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959] 178.889 173.475
transforming protein rhoc (h9). [swissprot;acc:p08134] Subtracted 199.266 205.632 6.366
1047 steroid hormone receptor err1 (estrogen-related receptor, alpha) (err-alpha) (estrogen receptor-like 1). [swissprot;acc:p11474] Divided 181.391 187.022 1.03104
thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762] Subtracted 199.266 205.632 6.366
1048 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5] Divided 182.308 187.96 1.031
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325] Subtracted 199.266 205.632 6.366
1049 adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741] Divided 217.998 211.449 1.03097
transforming protein rhoa (h12). [swissprot;acc:p06749] Subtracted 199.266 205.632 6.366
1050 bystin. [swissprot;acc:q13895] 233.185 239.505 6.32
estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061] Divided 217.998 211.449 1.03097
1051 17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995] Subtracted 213.378 219.673 6.295
1052 lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046] 226.584 220.291 6.293
retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725] Divided 217.998 211.449 1.03097
1053 annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073] Subtracted 213.385 219.655 6.27
proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066] Divided 200.84 207.04 1.03087
1054 60s ribosomal protein l21. [swissprot;acc:p46778] 217.263 223.958 1.03082
proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066] Subtracted 200.84 207.04 6.2
1055 hcv ns3-transactivated protein 1. [refseq;acc:nm_019048] Divided 212.468 219.01 1.03079
hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0] Subtracted 132.538 138.705 6.167
1056 methyltransferase like 2. [refseq;acc:nm_018396] 153.371 147.211 6.16
vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606] Divided 212.468 219.01 1.03079
1057 asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]
cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763] Subtracted 153.371 147.211 6.16
1058 ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245] Divided 221.293 228.105 1.03078
fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263] Subtracted 153.371 147.211 6.16
1059 ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973] Divided 221.293 228.105 1.03078
proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824] Subtracted 153.371 147.211 6.16
1060 nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231] Divided 211.648 218.162 1.03078
septin 6. [swissprot;acc:q14141] Subtracted 120.463 126.604 6.141
1061 adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2] 211.185 217.323 6.138
elks protein. [refseq;acc:nm_015064] Divided 211.648 218.162 1.03078
1062 brain protein 44. [swissprot;acc:o95563] Subtracted 120.078 126.215 6.137
zinc finger protein 174 (aw-1). [swissprot;acc:q15697] Divided 278.239 269.963 1.03066

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/