MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	Value Type	Gene	description	green	Rank	network_comparison	Network Comparison Type	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 51 to 100 of 14920 in total

Filtered  : 0
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	green	Rank	network_comparison	red
alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]	1504.85	452	1.01496	1527.36
alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]	1759.22	231	1.14705	2017.91
aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	1312.91	266	1.1235	1475.05
alpha crystallin a chain. [swissprot;acc:p02489]	89.2447	86	1.61366	55.3059
alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	2335.98	475	1.00722	2319.24
alpha-nac protein. [sptrembl;acc:q9h009]	151.122	436	1.0265	147.221
alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	475	116	1.40632	668
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	14167	332	1.08783	15411.3
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	12125.1	276	1.12092	10817.1
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	1354.26	164	1.26383	1711.55
ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	2076.5	211	1.18661	2464
arp2/3 complex 41 kda subunit (p41-arc) (actin-related protein 2/3 complex subunit 1b). [swissprot;acc:o15143]	2194.52	337	1.07624	2039.07
arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681]	1376.88	213	1.18471	1162.21
aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]	6303	441	1.02355	6158
associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	561.038	139	1.31317	736.737
ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	14756	216	1.18256	12478
atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	429	477	1.00704	426
atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031]	931.405	377	1.05332	884.254
atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]	402	100	1.47761	594
ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9]	12473	292	1.11138	11223
ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	904.149	191	1.21678	743.066
ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	6410	9	75.4118	85
baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392]	13463.1	348	1.0664	14357.1
basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	421	108	1.44178	292
beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	139	28	4.10072	570
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	335	133	1.32937	252
block 23. [sptrembl;acc:q8nhw5]	2159.55	293	1.11127	1943.32
blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	306.727	184	1.22281	375.07
	306.933	185		375.322
blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	306.727	183		375.07
bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	1356.52	453	1.01438	1337.29
bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	859.34	74	1.71473	501.151
brain protein 16. [refseq;acc:nm_016458]	2418.14	274	1.12172	2155.75
brca1 associated protein. [refseq;acc:nm_006768]	0.00001	502	1	0.00001
bystin. [swissprot;acc:q13895]	3135.76	343	1.0699	2930.88
c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	1463.55	261	1.12945	1295.81
cab2. [refseq;acc:nm_033419]	174	2	17400000	0.00001
calcyphosine. [swissprot;acc:q13938]	635.875	126	1.3457	472.524
camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612]	2633.79	381	1.04972	2509.05
carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	576	316	1.09714	525
cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	339.154	207	1.19069	403.827
casein kinase i alpha s-like. [refseq;acc:nm_145203]	1933.94	238	1.13678	2198.47
ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	891.114	141	1.30385	1161.88
cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]	610.424	279	1.11819	545.902
cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	1268.19	319	1.09483	1388.45
cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	184	32	3.25	598
chromodomain y-like protein 2. [refseq;acc:nm_152342]	2799.81	326	1.09054	3053.31
clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	6127.24	286	1.11465	5497.01
cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	4102.97	173	1.25656	3265.25
cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	758.411	226	1.15165	658.544

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.