MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	Network Comparison Type	description	Rank	Filtered	Interaction Map	network_comparison	green	red

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	green	red
polybromo 1. [refseq;acc:nm_018165]	2591	1.00147	219.696	220.02
polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	784	1.04789	235.131	224.385
polyhomeotic like 3; early development regulator 3; polyhomeotic 3. [refseq;acc:nm_024947]	2809	1	0.00001	0.00001
polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	435	1.07909	205.286	221.522
polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999]	2095	1.00763	227.53	229.266
polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	429	1.08064	259.038	239.709
polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	451	1.07785	257.705	239.092
polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	1204	1.02535	213.607	219.022
polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	953	1.03512	205.466	198.494
polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [refseq;acc:nm_004481]	1811	1.01168	214.35	216.854
polyposis locus protein 1 (tb2 protein). [swissprot;acc:q00765]	1412	1.02095	210.42	206.102
polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]	1414
polypyrimidine tract binding protein 2; neural polypyrimidine tract binding protein; ptb-like protein. [refseq;acc:nm_021190]	1382	1.02148	213.876	218.47
polypyrimidine tract-binding protein 1 (ptb) (heterogeneous nuclear ribonucleoprotein i) (hnrnp i) (57 kda rna-binding protein pptb-1). [swissprot;acc:p26599]	1394		213.875
ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	918	1.03731	205.292	212.952
porphobilinogen deaminase (ec 4.3.1.8) (hydroxymethylbilane synthase) (hmbs) (pre-uroporphyrinogen synthase) (pbg-d). [swissprot;acc:p08397]	2708	1.0006	227.66	227.796
possible global transcription activator snf2l1. [swissprot;acc:p28370]	2594	1.00147	219.696	220.02
possible global transcription activator snf2l2 (snf2-alpha). [swissprot;acc:p51531]	2596
possible global transcription activator snf2l4 (snf2-beta) (brg-1 protein) (mitotic growth and transcription activator) (brahma protein homolog 1). [swissprot;acc:p51532]	2593
postsynaptic protein cript; hspc139 protein. [refseq;acc:nm_014171]	3034	1	0.00001	0.00001
potassium channel modulatory factor 1; potassium channel modulatory factor; differentially expressed in branching tubulogenesis 91; zinc finger, zz domain containing 1. [refseq;acc:nm_020122]	2119	1.00696	222.788	221.248
potassium channel tetramerisation domain containing 3; ny-ren-45 antigen. [refseq;acc:nm_016121]	2975	1	0.00001	0.00001
potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	145	1.20293	319.546	265.639
potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	475	1.07547	210.816	226.727
potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	474	1.07576	210.818	226.789
potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	476	1.07527	210.814	226.681
potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	123	1.21681	327.601	269.23
potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	120	1.21699	327.709	269.278
potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	122	1.21688	327.642	269.248
potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	718	1.05402	211.685	223.121
potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	714
potential phospholipid-transporting atpase ih (ec 3.6.3.1) (atpase class i type 11a) (atpase is). [swissprot;acc:p98196]	1843	1.01115	210.113	212.455
potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	1820	1.01164	217.926	220.462
pp1201 protein. [refseq;acc:nm_022152]	1627	1.01515	214.2	217.446
pp3111 protein. [refseq;acc:nm_022156]	236	1.11785	254.15	227.357
pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	641	1.05938	230.596	217.67
pre-b-cell leukemia transcription factor 4. [refseq;acc:nm_025245]	1787	1.01206	203.874	206.332
pre-b-cell leukemia transcription factor-1 (homeobox protein pbx1) (homeobox protein prl). [swissprot;acc:p40424]	1779
pre-b-cell leukemia transcription factor-2 (homeobox protein pbx2) (g17 protein). [swissprot;acc:p40425]	1786
pre-b-cell leukemia transcription factor-3 (homeobox protein pbx3). [swissprot;acc:p40426]	1781
pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	2635	1.00132	166.393	166.612
pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	1445	1.02003	136.922	134.233
pre-mrna cleavage factor i, 59 kda subunit. [refseq;acc:nm_024811]	1743	1.01288	215.402	218.176
pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	473	1.07637	209.651	225.661
pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	594	1.06256	210.136	223.282
prefoldin subunit 1. [swissprot;acc:o60925]	1645	1.01451	214.149	217.256
prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	1310	1.02341	221.26	226.439
prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	1309
prefoldin subunit 4 (protein c-1). [swissprot;acc:q9nqp4]	3130	1	0.00001	0.00001
prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	977	1.03402	221.421	228.953

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.