Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 2012 to 2061 of 3228 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
red
green
network_comparison
2012 DDX43 dead-box protein. [refseq;acc:nm_018665] 193.517 191.766 1.00913
2013 PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12b isoform a; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2. [refseq;acc:nm_002481] 217.662 215.693
2014 PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12a; myosin phosphatase, target subunit 1. [refseq;acc:nm_002480] 217.676 215.709 1.00912
2015 TOP3A dna topoisomerase iii alpha (ec 5.99.1.2). [swissprot;acc:q13472] 217.941 215.979 1.00908
2016 ETFDH electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134] 199.092 197.301
2017 RRS1 ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050] 127.397 128.553 1.00907
2018 PPP1CA serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]
2019 no value acyl-coa dehydrogenase, short/branched chain specific, mitochondrial precursor (ec 1.3.99.-) (sbcad) (2-methyl branched chain acyl-coa dehydrogenase) (2-mebcad) (2-methylbutyryl-coenzyme a dehydrogenase) (2-methylbutyryl-coa dehydrogenase). [swissprot;acc:p45954] 215.799 213.865 1.00904
2020 KIAA0664 putative eukaryotic translation initiation factor 3 subunit (eif-3) (fragment). [swissprot;acc:o75153] 223.168 221.176 1.00901
2021 COQ3 hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor (ec 2.1.1.114) (dihydroxyhexaprenylbenzoate methyltransferase) (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (dhhb methyltransferase) (dhhb-mt) (dhhb-mtase). [swissprot;acc:q9nzj6] 208.601 210.464 1.00893
2022 ATP5S atp synthase coupling factor b, mitochondrial precursor. [swissprot;acc:q99766]
2023 GDA guanine deaminase (ec 3.5.4.3) (guanase) (guanine aminase) (guanine aminohydrolase) (gah) (p51-nedasin). [swissprot;acc:q9y2t3]
2024 VPS33B vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267] 215.553 213.663 1.00885
2025 GPT alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298] 189.987 191.668
2026 VPS11 vacuolar protein sorting 11 (hvps11) (pp3476). [swissprot;acc:q9h270] 215.553 213.663
2027 LIN7C lin-7 homolog c; lin-7 protein 3. [refseq;acc:nm_018362] 225.015 223.041
2028 VPS33A vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1] 215.553 213.663
2029 CCBL1 cytoplasmic cysteine conjugate-beta lyase; glutamine-phenylpyruvate aminotransferase. [refseq;acc:nm_004059] 189.999 191.677 1.00883
2030 GPT2 alanine aminotransferase 2; glutamic-pyruvate transaminase 2. [refseq;acc:nm_133443]
2031 TTRAP traf and tnf receptor-associated protein; ets1-associated protein 2. [refseq;acc:nm_016614] 218.466 216.562 1.00879
2032 CAPZA3 f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2] 215.322 213.46 1.00872
2033 CAPZB f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]
2034 CENTB5 centaurin beta 5 (cnt-b5). [swissprot;acc:q96p50] 218.919 220.812 1.00865
2035 CENTB2 centaurin beta 2 (cnt-b2). [swissprot;acc:q15057]
2036 LMNB1 lamin b1. [swissprot;acc:p20700] 220.813
2037 CENTB1 centaurin beta 1 (cnt-b1). [swissprot;acc:q15027] 220.812
2038 LMNA lamin a/c (70 kda lamin). [swissprot;acc:p02545] 218.92 220.811 1.00864
2039 ACSS2 acetyl-coenzyme a synthetase, cytoplasmic (ec 6.2.1.1) (acetate--coa ligase) (acyl-activating enzyme) (acetyl-coa synthetase) (acs) (acecs). [swissprot;acc:q9nr19] 190.551 192.191 1.00861
2040 T brachyury protein (t protein). [swissprot;acc:o15178] 210.586 208.803 1.00854
2041 UBQLN4 ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131] 196.808 195.141
2042 TBX19 t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806] 210.586 208.803
2043 UBQLN1 ubiquilin 1 isoform 1. [refseq;acc:nm_013438] 196.837 195.173 1.00853
2044 AP3B1 adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203] 199.928 198.24 1.00851
2045 C19orf29 ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4]
2046 no value adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]
2047 SLC2A6 solute carrier family 2, facilitated glucose transporter, member 6 (glucose transporter type 6) (glucose transporter type 9). [swissprot;acc:q9ugq3] 224.124 226.003 1.00838
2048 SLC2A8 solute carrier family 2, facilitated glucose transporter, member 8 (glucose transporter type 8) (glucose transporter type x1). [swissprot;acc:q9ny64]
2049 EIF2B2 translation initiation factor eif-2b beta subunit (eif-2b gdp-gtp exchange factor) (s20i15) (s20iii15). [swissprot;acc:p49770] 220.787 222.634 1.00837
2050 SH3BGR sh3 domain-binding glutamic acid-rich protein (sh3bgr protein) (21- glutamic acid-rich protein) (21-garp). [swissprot;acc:p55822] 218.79 216.981 1.00834
2051 OXR1 oxidation resistance 1. [refseq;acc:nm_181354]
2052 AZIN1 ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977] 207.667 205.95
2053 LATS2 lats, large tumor suppressor, homolog 2; lats (large tumor suppressor, drosophila) homolog 2. [refseq;acc:nm_014572] 218.79 216.981
2054 ADC ornithine decarboxylase-like protein (ec 4.1.1.17) (odc-paralogue) (odc-p). [swissprot;acc:q96a70] 207.665 205.948
2055 DYM dymeclin. [refseq;acc:nm_017653] 218.79 216.981
2056 SH3BGRL sh3 domain-binding glutamic acid-rich-like protein. [swissprot;acc:o75368]
2057 LATS1 lats homolog 1. [refseq;acc:nm_004690]
2058 no value sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]
2059 NCOA7 nuclear receptor coactivator 7; estrogen receptor associated protein 140 kda. [refseq;acc:nm_181782]
2060 C20orf118 dj132f21.2 (contains a novel protein similar to the l82e from drosophila) (fragment). [sptrembl;acc:q9h125]
2061 TBC1D22B tbc1 domain family protein c22orf4-like (fragment). [swissprot;acc:q9nu19]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/