MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1963 to 2012 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	red	green	network_comparison
1963	HSPE1	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	211.633	213.703	1.00978
1964	RABAC1	rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]
1965	ADD1	alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	224.432	222.258
1966	REXO2	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8]	211.633	213.703
1967	CHAT	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]	211.632	213.702
1968	KCNAB2	voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303]	211.633	213.703
1969	AKR7A2	aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]
1970	KPNA6	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	211.62	213.683	1.00975
1971	CKM	creatine kinase, m chain (ec 2.7.3.2) (m-ck). [swissprot;acc:p06732]	198.258	196.346	1.00974
1972	SEC16B	regucalcin gene promotor region related protein; rgpr-p117. [refseq;acc:nm_033127]	219.777	217.659	1.00973
1973	no value	wiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (verprolin homology domain-containing protein 2). [swissprot;acc:q9y6w5]	214.611	212.546	1.00972
1974	WASF3	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]
1975	WASF1	wiskott-aldrich syndrome protein family member 1 (wasp-family protein member 1) (verprolin homology domain-containing protein 1). [swissprot;acc:q92558]
1976	RCOR1	rest corepressor. [refseq;acc:nm_015156]
1977	MAF1	homolog of yeast maf1. [refseq;acc:nm_032272]	209.539	207.529	1.00969
1978	SERINC2	tumor differentially expressed protein 2. [refseq;acc:nm_178865]
1979	SERINC3	tumor differentially expressed protein 1 (transmembrane protein sbbi99). [swissprot;acc:q13530]
1980	SERINC1	tumor differentially expressed 1 protein like. [swissprot;acc:q9nrx5]
1981	PHGDH	d-3-phosphoglycerate dehydrogenase (ec 1.1.1.95) (3-pgdh). [swissprot;acc:o43175]
1982	no value	40s ribosomal protein s28. [swissprot;acc:p25112]	200.343	198.427	1.00966
1983	PDLIM5	lim protein (similar to rat protein kinase c-binding enigma); enigma homolog. [refseq;acc:nm_006457]	219.25	217.175	1.00955
1984	EP400	e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]	219.26	217.193	1.00952
1985	MRPL24	mitochondrial ribosomal protein l24. [refseq;acc:nm_024540]
1986	YAP1	65 kda yes-associated protein (yap65). [swissprot;acc:p46937]
1987	LIN7A	lin-7 homolog a; vertebrate lin7 homolog 1; tax interaction protein 33; mammalian lin-7 1. [refseq;acc:nm_004664]	225.022	222.9
1988	CCDC130	9 kda protein. [swissprot;acc:p13994]	219.26	217.193
1989	COL4A3	collagen alpha 3(iv) chain precursor (goodpasture antigen). [swissprot;acc:q01955]	219.261	217.195	1.00951
1990	no value	collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400]	219.26	217.194
1991	WWTR1	transcriptional co-activator with pdz-binding motif (taz). [refseq;acc:nm_015472]
1992	LDB3	zasp protein (fragment). [sptrembl;acc:q9y4z3]	219.267	217.207	1.00948
1993	HIP1R	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	189.052	190.835	1.00943
1994	COL4A3BP	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	189.011	190.787	1.0094
1995	HIP1	huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	188.961	190.73	1.00936
1996	SLC5A5	sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911]	204.682	202.784
1997	PRODH2	kidney and liver proline oxidase 1. [refseq;acc:nm_021232]	204.651	202.759	1.00933
1998	C15orf15	ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304]	200.219	198.37	1.00932
1999	SLC5A8	solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913]	204.636	202.748	1.00931
2000	SLC5A6	sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289]	204.626	202.739
2001	LIN7B	lin-7 homolog b; lin-7b protein; likely ortholog of mouse lin-7b; mammalian lin-7 protein 2; likely orholog of mouse lin 7 homolog b (c. elegans). [refseq;acc:nm_022165]	225.02	222.948	1.00929
2002	SNRPB2	u2 small nuclear ribonucleoprotein b". [swissprot;acc:p08579]	214.775	216.769	1.00928
2003	DNALI1	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]	208.315	206.41	1.00923
2004	ERBB4	receptor protein-tyrosine kinase erbb-4 precursor (ec 2.7.1.112) (p180erbb4) (tyrosine kinase-type cell surface receptor her4). [swissprot;acc:q15303]	225.019	222.969	1.00919
2005	EGFR	epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533]		222.971
2006	ERBB2	receptor protein-tyrosine kinase erbb-2 precursor (ec 2.7.1.112) (p185erbb2) (neu proto-oncogene) (c-erbb-2) (tyrosine kinase-type cell surface receptor her2) (mln 19). [swissprot;acc:p04626]
2007	HACL1	2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]		222.969
2008	ERBB3	receptor protein-tyrosine kinase erbb-3 precursor (ec 2.7.1.112) (c-erbb3) (tyrosine kinase-type cell surface receptor her3). [swissprot;acc:p21860]
2009	CTRL	proteasome subunit beta type 10 precursor (ec 3.4.25.1) (proteasome mecl-1) (macropain subunit mecl-1) (multicatalytic endopeptidase complex subunit mecl-1). [swissprot;acc:p40306]	216.201	214.245	1.00913
2010	TBCC	tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814]	193.517	191.766
2011	ACOT9	putative acyl-coa thioester hydrolase cgi-16 (ec 3.1.2.-). [swissprot;acc:q9y305]
2012	DDX43	dead-box protein. [refseq;acc:nm_018665]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.