MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	Value Type	Network Comparison Type	green	Interaction Map	description	red	network_comparison	Filtered

Results: HTML CSV LaTeX

Showing element 1930 to 1979 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	green	description	red	network_comparison
1930	198.935	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	196.964	1.01001
1931	217.574	eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371]	219.753
1932	198.936	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	196.965
1933	217.82	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	215.667	1.00998
1934	222.055	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	224.264	1.00995
1935	216.279	abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910]	218.43
1936	196.347	creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	198.3
1937	216.279	quaking isoform 6. [sptrembl;acc:q9p0x9]	218.43
1938	196.341	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	198.293	1.00994
1939	196.319	peptidyl prolyl isomerase h; cyclophilin h. [refseq;acc:nm_006347]	198.258	1.00988
1940	196.252	creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]	198.19
1941	196.319	prp18 pre-mrna processing factor 18 homolog. [refseq;acc:nm_003675]	198.258
1942		j domain protein c21orf55. [swissprot;acc:q9nx36]	198.257	1.00987
1943	222.147	megf11 protein. [refseq;acc:nm_032445]	224.34
1944	222.148	megf10 protein. [refseq;acc:nm_032446]	224.341
1945	222.151	beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612]	224.343
1946	212.142	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	214.234	1.00986
1947	127.083	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	125.845	1.00984
1948	212.432	15 kda selenoprotein precursor. [swissprot;acc:o60613]	214.522
1949	216.663	rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062]	218.794
1950	213.747	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	215.847	1.00982
1951	203.873	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]	205.876
1952	213.724	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294]	211.647	1.00981
1953	127.146	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	125.912	1.0098
1954	213.703	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448]	211.632	1.00979
1955		yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470]	211.633	1.00978
1956		voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]
1957		similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]
1958		aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]
1959		alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]
1960		golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]
1961		alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
1962	213.702	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	211.632
1963	213.703	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	211.633
1964		rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]
1965	222.258	alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	224.432
1966	213.703	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8]	211.633
1967	213.702	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]	211.632
1968	213.703	voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303]	211.633
1969		aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]
1970	213.683	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	211.62	1.00975
1971	196.346	creatine kinase, m chain (ec 2.7.3.2) (m-ck). [swissprot;acc:p06732]	198.258	1.00974
1972	217.659	regucalcin gene promotor region related protein; rgpr-p117. [refseq;acc:nm_033127]	219.777	1.00973
1973	212.546	wiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (verprolin homology domain-containing protein 2). [swissprot;acc:q9y6w5]	214.611	1.00972
1974		wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]
1975		wiskott-aldrich syndrome protein family member 1 (wasp-family protein member 1) (verprolin homology domain-containing protein 1). [swissprot;acc:q92558]
1976		rest corepressor. [refseq;acc:nm_015156]
1977	207.529	homolog of yeast maf1. [refseq;acc:nm_032272]	209.539	1.00969
1978		tumor differentially expressed protein 2. [refseq;acc:nm_178865]
1979		tumor differentially expressed protein 1 (transmembrane protein sbbi99). [swissprot;acc:q13530]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.