Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1913 to 1962 of 3228 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
description
red
green
network_comparison
1913 calcium-binding mitochondrial carrier protein aralar1 (solute carrier family 25, member 12). [swissprot;acc:o75746] 6858.84 7287.27 1.06246
1914 melanoma antigen recognized by t cells 2. [refseq;acc:nm_018194]
1915 5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196]
1916 calcium-binding mitochondrial carrier protein aralar2 (solute carrier family 25, member 13) (citrin). [swissprot;acc:q9ujs0]
1917 acyl carrier protein, mitochondrial precursor (acp) (nadh-ubiquinone oxidoreductase 9.6 kda subunit) (ci-sdap). [swissprot;acc:o14561]
1918 seven in absentia homolog 1. [refseq;acc:nm_003031] 5394.24 5730.73 1.06238
1919 hydroxyindole o-methyltransferase (ec 2.1.1.4) (hiomt) (acetylserotonin o-methyltransferase) (asmt). [swissprot;acc:p46597] 5444.6 5783.95 1.06233
1920 basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811] 6262.66 6652.85 1.0623
1921 salivary proline-rich protein po (allele k) [contains: peptide p-d] (fragment). [swissprot;acc:p10162]
1922 hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543] 5567.41 5914.05 1.06226
1923 brain protein 16. [refseq;acc:nm_016458] 5774.02 6133.01 1.06217
1924 transcriptional adaptor 3-like isoform a. [refseq;acc:nm_006354] 7260.23 7711.3 1.06213
1925 bromodomain containing 7; bromodomain protein; bromodomain-containing 7. [refseq;acc:nm_013263] 7711.29
1926 frg1 protein (fshd region gene 1 protein). [swissprot;acc:q14331] 7711.3
1927 transcriptional adapter 2-like (ada2-like protein) (kl04p). [swissprot;acc:o75478]
1928 son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889] 7514.8 7980.22 1.06193
1929 pxr2b protein. [refseq;acc:nm_016559] 6996.51 7429.18 1.06184
1930 p28 ing5. [refseq;acc:nm_032329] 5784.06 6141.48 1.06179
1931 ring finger protein 25 (ec 6.3.2.-). [swissprot;acc:q96bh1] 9946.21 9367.66 1.06176
1932 hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712] 10300 9701.33 1.06171
1933 conserved oligomeric golgi complex component 7. [swissprot;acc:p83436]
1934 transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [swissprot;acc:q9y4p3] 5949.31 6313.1 1.06115
1935 serine palmitoyltransferase 1 (ec 2.3.1.50) (long chain base biosynthesis protein 1) (lcb 1) (serine-palmitoyl-coa transferase 1) (spt 1) (spt1). [swissprot;acc:o15269] 6167.29 6544.12 1.0611
1936 williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645] 5171.45 5486.96 1.06101
1937 williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]
1938 williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]
1939 brca1-associated ring domain protein 1 (bard-1). [swissprot;acc:q99728] 5669.9 6015.75 1.061
1940 m-phase inducer phosphatase 3 (ec 3.1.3.48) (dual specificity phosphatase cdc25c). [swissprot;acc:p30307] 4450.17 4721.37 1.06094
1941 rac gtpase activating protein 1; gtpase activating protein. [refseq;acc:nm_013277] 5521.07 5856.93 1.06083
1942 pre-mrna cleavage factor i, 59 kda subunit. [refseq;acc:nm_024811] 5805.06 6158.16
1943 p300/cbp-associated factor (ec 2.3.1.-) (p/caf) (histone acetylase pcaf). [swissprot;acc:q92831] 7210.87 7649.23 1.06079
1944 general control of amino acid synthesis protein 5-like 2 (ec 2.3.1.-) (histone acetyltransferase gcn5) (hsgcn5). [swissprot;acc:q92830] 7210.64 7648.94
1945 cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [swissprot;acc:p23528] 6230.21 6608.64 1.06074
1946 cofilin, muscle isoform (cofilin 2). [swissprot;acc:q9y281]
1947 transcription initiation factor tfiid 100 kda subunit (tafii-100) (tafii100). [swissprot;acc:q15542] 7195.76 7632.83
1948 destrin (actin-depolymerizing factor) (adf). [swissprot;acc:p18282] 6230.21 6608.64
1949 ubiquitin fusion degradation protein 1 homolog (ub fusion protein 1). [swissprot;acc:q92890]
1950 glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292] 5888.32 6245.89 1.06073
1951 fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]
1952 coactosin-like protein. [swissprot;acc:q14019]
1953 uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]
1954 probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]
1955 28s ribosomal protein s16, mitochondrial precursor (mrp-s16) (cgi- 132). [swissprot;acc:q9y3d3] 5195.3 5510.67 1.0607
1956 nin one binding protein; adenocarcinoma antigen recognized by t lymphocytes 4. [refseq;acc:nm_014062] 4689.78 4973.44 1.06048
1957 transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [swissprot;acc:q16514] 7019.78 7444.06 1.06044
1958 splicing coactivator subunit srm300; rna binding protein; at-rich element binding factor. [refseq;acc:nm_016333] 5448.35 5777.35 1.06039
1959 splicing factor u2af 35 kda subunit (u2 auxiliary factor 35 kda subunit) (u2 snrnp auxiliary factor small subunit). [swissprot;acc:q01081]
1960 rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]
1961 splicing factor u2af 65 kda subunit (u2 auxiliary factor 65 kda subunit) (u2 snrnp auxiliary factor large subunit) (hu2af(65)). [swissprot;acc:p26368]
1962 c-jun-amino-terminal kinase interacting protein 3 (jnk-interacting protein 3) (jip-3) (jnk map kinase scaffold protein 3) (mitogen- activated protein kinase 8-interacting protein 3). [swissprot;acc:q9upt6] 5941.24 6297.78 1.06001

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/