Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1900 to 1949 of 3228 in total 
Value Type	Measured
Network Comparison Type	Divided
Interaction Map	High confidence
Filtered	1

Rank	description	red	green	network_comparison	
1900	seven in absentia homolog 2. [source:refseq;acc:nm_005067]	5399.47	5737.79	1.06266	
1901	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [source:swissprot;acc:q15181]	5204.25	5530.11	1.06261	
1902	inorganic pyrophosphatase 2 isoform 1. [source:refseq;acc:nm_176869]	5204.25	5530.11	1.06261	
1903	aryl-hydrocarbon interacting protein-like 1. [source:swissprot;acc:q9nzn9]	5204.25	5530.11	1.06261	
1904	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [source:swissprot;acc:o00170]	5204.25	5530.11	1.06261	
1905	son of sevenless protein homolog 2 (sos-2). [source:swissprot;acc:q07890]	7497.96	7967.09	1.06257	
1906	mitochondrial ribosomal protein l18. [source:refseq;acc:nm_014161]	5396.61	5733.93	1.06251	
1907	hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [source:refseq;acc:nm_023934]	6858.84	7287.27	1.06246	
1908	dc11 protein. [source:refseq;acc:nm_020186]	6858.84	7287.27	1.06246	
1909	amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [source:refseq;acc:nm_003905]	6858.84	7287.27	1.06246	
1910	5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [source:swissprot;acc:p22557]	6858.84	7287.27	1.06246	
1911	ubiquitin-activating enzyme e1c (uba3 homolog, yeast); ubiquitin-activating enzyme e1c (homologous to yeast uba3). [source:refseq;acc:nm_003968]	6858.84	7287.27	1.06246	
1912	ubiquitin-activating enzyme e1 (a1s9 protein). [source:swissprot;acc:p22314]	6858.84	7287.27	1.06246	
1913	calcium-binding mitochondrial carrier protein aralar1 (solute carrier family 25, member 12). [source:swissprot;acc:o75746]	6858.84	7287.27	1.06246	
1914	melanoma antigen recognized by t cells 2. [source:refseq;acc:nm_018194]	6858.84	7287.27	1.06246	
1915	5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [source:swissprot;acc:p13196]	6858.84	7287.27	1.06246	
1916	calcium-binding mitochondrial carrier protein aralar2 (solute carrier family 25, member 13) (citrin). [source:swissprot;acc:q9ujs0]	6858.84	7287.27	1.06246	
1917	acyl carrier protein, mitochondrial precursor (acp) (nadh-ubiquinone oxidoreductase 9.6 kda subunit) (ci-sdap). [source:swissprot;acc:o14561]	6858.84	7287.27	1.06246	
1918	seven in absentia homolog 1. [source:refseq;acc:nm_003031]	5394.24	5730.73	1.06238	
1919	hydroxyindole o-methyltransferase (ec 2.1.1.4) (hiomt) (acetylserotonin o-methyltransferase) (asmt). [source:swissprot;acc:p46597]	5444.6	5783.95	1.06233	
1920	basic proline-rich peptide p-e (ib-9). [source:swissprot;acc:p02811]	6262.66	6652.85	1.0623	
1921	salivary proline-rich protein po (allele k) [contains: peptide p-d] (fragment). [source:swissprot;acc:p10162]	6262.66	6652.85	1.0623	
1922	hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [source:swissprot;acc:q16543]	5567.41	5914.05	1.06226	
1923	brain protein 16. [source:refseq;acc:nm_016458]	5774.02	6133.01	1.06217	
1924	transcriptional adaptor 3-like isoform a. [source:refseq;acc:nm_006354]	7260.23	7711.3	1.06213	
1925	bromodomain containing 7; bromodomain protein; bromodomain-containing 7. [source:refseq;acc:nm_013263]	7260.23	7711.29	1.06213	
1926	frg1 protein (fshd region gene 1 protein). [source:swissprot;acc:q14331]	7260.23	7711.3	1.06213	
1927	transcriptional adapter 2-like (ada2-like protein) (kl04p). [source:swissprot;acc:o75478]	7260.23	7711.3	1.06213	
1928	son of sevenless protein homolog 1 (sos-1). [source:swissprot;acc:q07889]	7514.8	7980.22	1.06193	
1929	pxr2b protein. [source:refseq;acc:nm_016559]	6996.51	7429.18	1.06184	
1930	p28 ing5. [source:refseq;acc:nm_032329]	5784.06	6141.48	1.06179	
1931	ring finger protein 25 (ec 6.3.2.-). [source:swissprot;acc:q96bh1]	9946.21	9367.66	1.06176	
1932	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [source:refseq;acc:nm_004712]	10300	9701.33	1.06171	
1933	conserved oligomeric golgi complex component 7. [source:swissprot;acc:p83436]	10300	9701.33	1.06171	
1934	transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [source:swissprot;acc:q9y4p3]	5949.31	6313.1	1.06115	
1935	serine palmitoyltransferase 1 (ec 2.3.1.50) (long chain base biosynthesis protein 1) (lcb 1) (serine-palmitoyl-coa transferase 1) (spt 1) (spt1). [source:swissprot;acc:o15269]	6167.29	6544.12	1.0611	
1936	williams-beuren syndrome critical region protein 20 copy b. [source:refseq;acc:nm_145645]	5171.45	5486.96	1.06101	
1937	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [source:refseq;acc:nm_018044]	5171.45	5486.96	1.06101	
1938	williams beuren syndrome chromosome region 20c isoform 1. [source:refseq;acc:nm_032158]	5171.45	5486.96	1.06101	
1939	brca1-associated ring domain protein 1 (bard-1). [source:swissprot;acc:q99728]	5669.9	6015.75	1.061	
1940	m-phase inducer phosphatase 3 (ec 3.1.3.48) (dual specificity phosphatase cdc25c). [source:swissprot;acc:p30307]	4450.17	4721.37	1.06094	
1941	rac gtpase activating protein 1; gtpase activating protein. [source:refseq;acc:nm_013277]	5521.07	5856.93	1.06083	
1942	pre-mrna cleavage factor i, 59 kda subunit. [source:refseq;acc:nm_024811]	5805.06	6158.16	1.06083	
1943	p300/cbp-associated factor (ec 2.3.1.-) (p/caf) (histone acetylase pcaf). [source:swissprot;acc:q92831]	7210.87	7649.23	1.06079	
1944	general control of amino acid synthesis protein 5-like 2 (ec 2.3.1.-) (histone acetyltransferase gcn5) (hsgcn5). [source:swissprot;acc:q92830]	7210.64	7648.94	1.06079	
1945	cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [source:swissprot;acc:p23528]	6230.21	6608.64	1.06074	
1946	cofilin, muscle isoform (cofilin 2). [source:swissprot;acc:q9y281]	6230.21	6608.64	1.06074	
1947	transcription initiation factor tfiid 100 kda subunit (tafii-100) (tafii100). [source:swissprot;acc:q15542]	7195.76	7632.83	1.06074	
1948	destrin (actin-depolymerizing factor) (adf). [source:swissprot;acc:p18282]	6230.21	6608.64	1.06074	
1949	ubiquitin fusion degradation protein 1 homolog (ub fusion protein 1). [source:swissprot;acc:q92890]	6230.21	6608.64	1.06074	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/