MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	red	Value Type	Rank	green	Interaction Map	description	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 1875 to 1924 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

red	Rank	green	description	network_comparison
5792.08	1126	6305.67	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	1.08867
5793.29	1368	6248.51	beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612]	1.07858
5793.47	1367	6248.71	megf10 protein. [refseq;acc:nm_032446]
5793.55	1366	6248.79	megf11 protein. [refseq;acc:nm_032445]
5794.8	810	6427.79	jm1 protein. [refseq;acc:nm_014008]	1.10923
5795.13	1115	6314.19	5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]	1.08957
5796.03	1431	6243.78	limkain beta 2. [refseq;acc:nm_025140]	1.07725
5797.88	877	6391.75	mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	1.10243
	878		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]
	879		nuclear pore complex protein nup88 (nucleoporin nup88) (88 kda nuclear pore complex protein). [swissprot;acc:q99567]
5798.31	1499	6230.55	hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]	1.07455
5799.14	1365	6255.04	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	1.07862
5799.29	1331	6265.2	transaldolase (ec 2.2.1.2). [swissprot;acc:p37837]	1.08034
5799.35	1173	6305.95	chaperone-activity of bc1 complex-like, mitochondrial precursor (chaperone-abc1-like). [swissprot;acc:q8ni60]	1.08735
	1175		aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [refseq;acc:nm_052853]
	1176		aarf domain containing kinase 4. [refseq;acc:nm_024876]
	1177		aarf domain containing kinase 1. [refseq;acc:nm_020421]
5799.84	2083	6122.18	ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]	1.05558
5800.22	2084	6122.6
5800.93	2082	6123.38	ran-binding protein 2 (ranbp2) (nuclear pore complex protein nup358) (nucleoporin nup358) (358 kda nucleoporin) (p270). [swissprot;acc:p49792]	1.05559
5800.95	994	6355.71	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]	1.09563
5803.1	1399	6256.03	heterogeneous nuclear ribonucleoprotein h' (hnrnp h') (ftp-3). [swissprot;acc:p55795]	1.07805
5803.12	1398	6256.05	heterogeneous nuclear ribonucleoprotein h (hnrnp h). [swissprot;acc:p31943]
5803.27	1397	6256.23	heterogeneous nuclear ribonucleoprotein f (hnrnp f). [swissprot;acc:p52597]
5803.45	1400	6256.43	heterogeneous nuclear ribonucleoprotein h3 (hnrnp h3) (hnrnp 2h9). [swissprot;acc:p31942]
5803.54	1396	6256.54	g-rich sequence factor-1 (grsf-1). [swissprot;acc:q12849]	1.07806
5803.95	1333	6269.44	abl-interactor 2; abl-interacting protein 1 (sh3-containing protein); abl binding protein 3; arg protein tyrosine kinase-binding protein; abl-interactor protein 2b; similar to spectrin sh3 domain binding protein 1. [refseq;acc:nm_005759]	1.0802
5804.75	1334	6270.15	spectrin sh3 domain binding protein 1; eps8 binding protein; interactor protein ablbp4; abl-interactor protein 1 long; nap1 binding protein. [refseq;acc:nm_005470]	1.08018
5805.06	1942	6158.16	pre-mrna cleavage factor i, 59 kda subunit. [refseq;acc:nm_024811]	1.06083
5807.83	1234	6300.47	similar to ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_145245]	1.08482
	1235		ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665]
5811.51	761	6467.62	translation initiation factor if-2. [swissprot;acc:o60841]	1.1129
5812.02	1411	6262.07	14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	1.07743
5813.84	1412	6263.92	histone deacetylase 5 (hd5) (antigen ny-co-9). [swissprot;acc:q9uql6]	1.07742
5813.88	1413	6263.97	histone deacetylase 9 (hd9) (hd7b) (hd7). [swissprot;acc:q9ukv0]
	1414	6263.96	histone deacetylase 4 (hd4). [swissprot;acc:p56524]	1.07741
5815.14	1364	6272.66	protein c20orf4 (protein cgi-23) (pro0225). [swissprot;acc:q9y312]	1.07868
5815.33	1415	6265.44	14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	1.0774
5816.12	1809	6196.21	epsin 3. [refseq;acc:nm_017957]	1.06535
5817.07	2090	6138.59	kh-type splicing regulatory protein (fuse binding protein 2); kh-type splicing regulatory protein (fuse-binding protein 2). [refseq;acc:nm_003685]	1.05527
5817.41	2092	6138.8	far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	1.05525
5817.56	2093	6138.9	fuse binding protein 3 (fragment). [sptrembl;acc:q92946]	1.05524
5819.36	2247	6092.93	rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062]	1.04701
5819.37	1569	6239.55	traf and tnf receptor-associated protein; ets1-associated protein 2. [refseq;acc:nm_016614]	1.0722
5819.39	1546	6244.37	26s proteasome non-atpase regulatory subunit 3 (26s proteasome regulatory subunit s3) (proteasome subunit p58). [swissprot;acc:o43242]	1.07303
5822.25	1567	6242.94	26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	1.07226
5825.61	2170	6126.74	exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]	1.05169
	2171		phd finger protein 9. [refseq;acc:nm_018062]
	2172		small optic lobes homolog; small optic lobes, drosophila, homolog of. [refseq;acc:nm_005632]
5826	1883	6195.48	26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	1.06342

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.