Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank Gene description Value Type Network Comparison Type Interaction Map Filtered green red network_comparison

Results: HTML CSV LaTeX

Showing element 1875 to 1924 of 7460 in total

Value Type

: Measured
Interaction Map

: High confidence

Rank	description	Network Comparison Type	Filtered	green	red	network_comparison
469	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Divided	0	221.565	219.759	1.00822
469	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Subtracted	1	10276.3	11143.5	867.2
470	block of proliferation 1. [swissprot;acc:q14137]	Divided	1	4348.59	3796.24	1.1455
	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	Divided	0	39485	39165	1.00817
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Subtracted	0	51	48	3
	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]		1	6233.12	5367.04	866.08
471	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]		0	51	48	3
	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	Divided	1	11053.5	9649.61	1.14549
	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	Subtracted	1	6843.48	5980.15	863.33
	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]	Divided	0	3825.73	3855.78	1.00785
472	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	Divided		3919.25	3889.5	1.00765
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Subtracted		51	48	3
	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]	Subtracted	1	6109.31	5246.01	863.3
	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	Divided	1	11053.5	9649.61	1.14549
473	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	Divided	0	3919.25	3889.5	1.00765
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Subtracted	0	51	48	3
	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	Subtracted	1	6842.78	5979.95	862.83
	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	Divided	1	11053.5	9649.61	1.14549
474	26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	Divided	0	2263.85	2281.12	1.00763
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	0	51	48	3
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	Subtracted	1	6842.76	5979.94	862.82
	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	Divided	1	11053.5	9649.61	1.14549
475	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	Divided	0	2335.98	2319.24	1.00722
	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	Subtracted	1	6842.72	5979.93	862.79
	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	Divided	1	11053.5	9649.61	1.14549
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Subtracted	0	51	48	3
476	dead/h (asp-glu-ala-asp/his) box polypeptide 11; dead/h box-11 (chl1-related helicase gene-1); yeast chl1 homolog. [refseq;acc:nm_030655]	Divided		1372.31	1362.55	1.00716
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted		51	48	3
	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	Divided	1	11053.5	9649.61	1.14549
	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Subtracted	1	5926.46	5067.02	859.44
477	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	Divided	0	429	426	1.00704
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	0	51	48	3
	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	Divided	1	11053.5	9649.61	1.14549
	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	Subtracted	1	5926.17	5067	859.17
478	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		0	51	48	3
	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]		1	5926.1	5066.99	859.11
	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	Divided	1	11053.5	9649.61	1.14549
	survival motor neuron protein (component of gems 1) (gemin1). [swissprot;acc:q16637]		0	701.071	705.758	1.00669
479	adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]			1310.67	1318.37	1.00587
	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	Subtracted		429	426	3
	ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304]	Subtracted	1	8029.64	7170.83	858.81
	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	Divided	1	11053.5	9649.61	1.14549
480	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted	0	51	48	3
	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	Divided	1	11053.5	9649.61	1.14549
	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	Divided	0	6396.8	6428	1.00488
	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	Subtracted	1	5925.38	5066.93	858.45
481	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]		1	6350.19	5493.1	857.09
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		0	51	48	3
	mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk kinase kinase 5) (mek kinase 5) (mekk 5) (apoptosis signal- regulating kinase 1) (ask-1). [swissprot;acc:q99683]	Divided	0	563.113	565.785	1.00475
	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	Divided	1	11053.5	9649.61	1.14549

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/