MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Gene	Filtered	description	Rank	Network Comparison Type	network_comparison	Interaction Map	red	green

Results: HTML CSV LaTeX

Showing element 51 to 100 of 3730 in total

Value Type  : Ranked
Filtered  : 0
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	network_comparison	red	green
alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]	169	1.13988	9875.43	11256.8
alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]	345	1.05086	11563.7	12151.8
aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	479	1.00826	15155.8	15031.7
alpha crystallin a chain. [swissprot;acc:p02489]	139	1.17178	16372.4	13972.2
alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	421	1.02942	11186	10866.3
alpha-nac protein. [sptrembl;acc:q9h009]	390	1.03662	14204.4	14724.5
alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	133	1.17537	6814	8009
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	279	1.08171	10614.2	9812.39
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	427	1.02719	11276.1	11582.7
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	118	1.19269	12049	14370.7
ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	52	1.38688	3284	4554.5
arp2/3 complex 41 kda subunit (p41-arc) (actin-related protein 2/3 complex subunit 1b). [swissprot;acc:o15143]	449	1.02129	9897.12	9690.83
arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681]	264	1.08947	10037.1	10935.1
aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]	466	1.01446	1543	1521
associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	278	1.08181	11644	10763.4
ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	74	1.29915	6742.5	8759.5
atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	476	1.00888	8403	8329
atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031]	224	1.10413	9815.6	8889.93
atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]	426	1.02805	9412.67	9676.67
ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9]	307	1.06856	1091	1021
ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	464	1.01494	10076.4	9928.08
ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	24	1.66289	13730.5	8257
baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392]	217	1.10858	7101.79	6406.18
basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	117	1.19285	11545	13771.5
beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	30	1.57201	7395	11625
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	237	1.10114	9984	9067
block 23. [sptrembl;acc:q8nhw5]	149	1.16265	11469.3	13334.8
blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	418	1.02995	16680.7	17180.3
	420	1.02991	16684	17183
blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	419
bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	114	1.19525	8871.11	10603.2
bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	91	1.24387	13841.2	11127.5
brain protein 16. [refseq;acc:nm_016458]	49	1.41927	6890.54	4854.99
brca1 associated protein. [refseq;acc:nm_006768]	502	1	0.00001	0.00001
bystin. [swissprot;acc:q13895]	384	1.03796	10833.3	11244.5
c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	208	1.11354	11846.3	10638.4
cab2. [refseq;acc:nm_033419]	7	1.99689	21866	10950
calcyphosine. [swissprot;acc:q13938]	374	1.04183	9874.54	9478.1
camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612]	300	1.0717	9270.49	8650.24
carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	347	1.0491	7670	7311
cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	50	1.41533	9249.73	13091.4
casein kinase i alpha s-like. [refseq;acc:nm_145203]	343	1.05173	8356.31	8788.62
ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	160	1.15331	11732	13530.6
cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]	451	1.01987	14010.2	13737.2
cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	245	1.09702	11867.6	13019
cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	38	1.48976	7230	10771
chromodomain y-like protein 2. [refseq;acc:nm_152342]	383	1.03816	10273.1	10665.1
clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	314	1.06369	10301.4	10957.5
cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	275	1.08264	10783	11674.1
cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	428	1.02658	11982.7	12301.2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.