MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1777 to 1826 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	green	network_comparison	red
1777	rho guanine nucleotide exchange factor 4 isoform a; apc-stimulated guanine nucleotide exchange factor. [refseq;acc:nm_015320]	214.286	1.0121	216.878
1778	cdc42 guanine exchange factor 9; hpem-2 collybistin. [refseq;acc:nm_015185]
1779	pre-b-cell leukemia transcription factor-1 (homeobox protein pbx1) (homeobox protein prl). [swissprot;acc:p40424]	203.874	1.01206	206.332
1780	germ cell-less. [refseq;acc:nm_022471]	203.877		206.335
1781	pre-b-cell leukemia transcription factor-3 (homeobox protein pbx3). [swissprot;acc:p40426]	203.874		206.332
1782	hyporthetical protein mgc27169. [refseq;acc:nm_176782]
1783	homeobox protein meis1. [swissprot;acc:o00470]
1784	homeobox protein meis2 (meis1-related protein 1). [swissprot;acc:o14770]
1785	bag-family molecular chaperone regulator-2. [swissprot;acc:o95816]
1786	pre-b-cell leukemia transcription factor-2 (homeobox protein pbx2) (g17 protein). [swissprot;acc:p40425]
1787	pre-b-cell leukemia transcription factor 4. [refseq;acc:nm_025245]
1788	homeobox protein meis3 (meis1-related protein 2) (fragment). [swissprot;acc:q99687]
1789	ribonuclease hi large subunit (ec 3.1.26.-) (rnase hi large subunit) (rnase h(35)) (ribonuclease h2) (rnase h2). [swissprot;acc:o75792]	213.539	1.01205	210.997
1790	dna topoisomerase ii, alpha isozyme (ec 5.99.1.3). [swissprot;acc:p11388]	201.349	1.01197	203.759
1791	elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576]	215.295	1.01194	217.866
1792	elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378]	215.199	1.01193	217.766
1793	putative nucleoside diphosphate kinase (ec 2.7.4.6) (ndk) (ndp kinase). [swissprot;acc:o60361]	190.823		193.1
1794	nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392]	190.861		193.138
1795	elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]	215.158		217.724
1796	dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880]	201.357		203.759
1797	nucleoside diphosphate kinase a (ec 2.7.4.6) (ndk a) (ndp kinase a) (tumor metastatic process-associated protein) (metastasis inhibition factor nm23) (nm23-h1). [swissprot;acc:p15531]	190.834		193.111
1798	elav-like protein 1 (hu-antigen r) (hur). [swissprot;acc:q15717]	215.242	1.01192	217.807
1799	alpha-actinin 2 (alpha actinin skeletal muscle isoform 2) (f-actin cross linking protein). [swissprot;acc:p35609]	214.481	1.01182	217.016
1800	dual-specificity tyrosine-phosphorylation regulated kinase 1a (ec 2.7.1.-) (protein kinase minibrain homolog) (mnbh) (hp86) (dual specificity yak1-related kinase). [swissprot;acc:q13627]		1.0118	217.011
1801	cug triplet repeat rna-binding protein 1 (cug-bp1) (rna-binding protein brunol-2) (deadenylation factor cug-bp) (50 kda nuclear polyadenylated rna-binding protein) (eden-bp). [swissprot;acc:q92879]	215.441		217.984
1802	elongation protein 4 homolog; pax6 neighbor gene; chromosome 11 open reading frame 19. [refseq;acc:nm_019040]	214.481		217.011
1803	dual-specificity tyrosine-phosphorylation regulated kinase 1b (ec 2.7.1.-) (mirk protein kinase). [swissprot;acc:q9y463]
1804	cug triplet repeat, rna binding protein 2; elav-type rna-binding protein; cug triplet repeat,rna-binding protein 2; cug triplet repeat, rna-binding protein 2; neuroblastoma apoptosis-related rna-binding protein. [refseq;acc:nm_006561]	215.442		217.984
1805	alpha-actinin 4 (non-muscle alpha-actinin 4) (f-actin cross linking protein). [swissprot;acc:o43707]	214.482	1.01178	217.008
1806	alpha-actinin 1 (alpha-actinin cytoskeletal isoform) (non-muscle alpha-actinin 1) (f-actin cross linking protein). [swissprot;acc:p12814]			217.009
1807	ral guanine nucleotide exchange factor ralgps1a. [refseq;acc:nm_014636]	208.651	1.01175	211.102
1808	ral-a exchange factor ralgps2. [refseq;acc:nm_152663]
1809	stip1 homology and u-box containing protein 1; serologically defined colon cancer antigen 7; carboxy terminus of hsp70p-interacting protein; heat shock protein a binding protein 2 (c-terminal). [refseq;acc:nm_005861]
1810	lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776]	225.827	1.01171	223.214
1811	polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [refseq;acc:nm_004481]	214.35	1.01168	216.854
1812	cyclin c. [swissprot;acc:p24863]	214.564		217.071
1813	similar to expressed sequence ai415388 (fragment). [sptrembl;acc:q8n428]	214.35		216.854
1814	serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873]	123.727	1.01167	122.3
1815	dpy-30-like protein. [swissprot;acc:q9c005]	217.926	1.01164	220.462
1816	rab coupling protein; rab-interacting recycling protein; rab effector protein; rab11-family interacting protein 1. [refseq;acc:nm_025151]
1817	gamma-snap-associated factor 1; rab11-interacting protein. [refseq;acc:nm_015470]
1818	neighbor of cox4. [swissprot;acc:o43402]
1819	protein c14orf122 (cgi-112). [swissprot;acc:q9y3b6]
1820	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]
1821	rna-binding region containing protein 1 (hsrnaseb) (ssdna binding protein seb4) (cll-associated antigen kw-5). [swissprot;acc:q9h0z9]	215.874	1.01152	218.36
1822	6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]	243.085	1.01151	240.32
1823	fragile x mental retardation syndrome related protein 2. [swissprot;acc:p51116]	200.086	1.0115	202.386
1824	f-actin capping protein alpha-1 subunit (capz alpha-1). [swissprot;acc:p52907]	212.281		214.722
1825	fragile x mental retardation syndrome related protein 1. [swissprot;acc:p51114]	200.086		202.386
1826	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	200.094	1.01149	202.393

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.