Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 175 to 224 of 502 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 0
Rank
Hugo
description
red
green
network_comparison
175 no value thiamin pyrophosphokinase 1; mouse thiamin pyrophosphokinase homolog; thiamine pyrophosphokinase. [refseq;acc:nm_022445] 13248.5 11666.4 1.13561
176 dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9] 13068 11528 1.13359
177 KCND2 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 14922.7 13174.5 1.1327
178 no value integral membrane protein cii-3b. [sptrembl;acc:o75609] 14951.6 13204.2 1.13234
179 MVK mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426] 9473.01 10723.7 1.13203
180 NOVA1 rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513] 8407.67 9516.92 1.13193
181 no value importin 7; ran-binding protein 7. [refseq;acc:nm_006391] 14864.7 16820.7 1.13159
182 NADK putative inorganic polyphosphate/atp-nad kinase (ec 2.7.1.23) (poly(p)/atp nad kinase). [swissprot;acc:o95544] 11573.8 10231.3 1.13121
183 no value ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 11613 13133.5 1.13093
184 similar to zinc finger protein 277. [sptrembl;acc:q8wwa6] 6279.56 5569.42 1.12751
185 zinc finger protein 277. [swissprot;acc:q9nrm2]
186 40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880] 11935.1 10592.8 1.12672
187 ADSSL1 adenylosuccinate synthase-like 1. [refseq;acc:nm_152328] 9955.22 11213.7 1.12641
188 RPL15 60s ribosomal protein l15. [swissprot;acc:p39030] 11745.2 13203.1 1.12413
189 SALL4 sal-like protein 4 (zinc finger protein sall4). [swissprot;acc:q9ujq4] 10634.4 9465 1.12355
190 no value high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9] 18809.5 16764.2 1.122
191 sh3 adapter protein spin90 (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia interacting protein-1) (dip-1). [swissprot;acc:q9nzq3]
192 CCT6A t-complex protein 1, zeta subunit (tcp-1-zeta) (cct-zeta) (cct-zeta-1) (tcp20) (htr3). [swissprot;acc:p40227] 12715.9 11333.2
193 GTF3A transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664] 10899.5 12217.4 1.12091
194 no value kappa b-ras 1. [refseq;acc:nm_020345] 12657.7 11299.1 1.12024
195 MRPS22 mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650] 13942.8 15586.4 1.11788
196 no value suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169] 11064.2 9897.84 1.11784
197 importin 4. [refseq;acc:nm_024658] 12337.6 13788.9 1.11763
198 RPL10L ribosomal protein l10-like protein. [refseq;acc:nm_080746] 11781.5 10545.3 1.11723
199 no value 60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635] 11781.8 10545.7 1.11721
200 MTRF1 peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570] 8786.74 7870.3 1.11644
201 no value maspin precursor (protease inhibitor 5). [swissprot;acc:p36952] 16853 15123 1.1144
202 serpin b11. [swissprot;acc:q96p15]
203 cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
204 DPP8 dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743] 15081.8 16802.1 1.11406
205 no value 60s ribosomal protein l23a. [swissprot;acc:p29316] 11844.9 10636.3 1.11363
206 hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934] 7479 6716 1.11361
207 dc11 protein. [refseq;acc:nm_020186]
208 c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02] 11846.3 10638.4 1.11354
209 small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578] 775 696 1.11351
210 MMS19 mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362] 17144.8 15405.6 1.11289
211 no value ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464] 10367 9320.25 1.11231
212 metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832] 18241.7 16405 1.11196
213 P4HB protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237] 9379.47 8436.39 1.11179
214 PET112L probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879] 7621.99 8473.85 1.11176
215 no value myosin vi. [swissprot;acc:q9um54] 10121.5 11250.5 1.11154
216 GSTZ1 maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708] 10559.7 11732 1.11102
217 BIRC5 baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392] 7101.79 6406.18 1.10858
218 no value lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 19355 17469.2 1.10795
219 SDHA succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040] 12196.2 11009.7 1.10777
220 NCALD neurocalcin delta. [swissprot;acc:p29554] 13973.6 15473.5 1.10734
221 no value estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 12190.3 13497.2 1.10721
222 40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174] 12183 11013.2 1.10622
223 pnas-18. [sptrembl;acc:q9bzu3] 12602.7 13939.6 1.10608
224 CLPX atp-dependent clp protease atp-binding subunit clpx-like, mitochondrial precursor. [swissprot;acc:o76031] 9815.6 8889.93 1.10413

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/