MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1713 to 1762 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
857	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Subtracted	228.698	237.218	8.52
	putatative 28 kda protein. [refseq;acc:nm_020143]	Divided	236.467	227.241	1.0406
858	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Subtracted	212.806	221.306	8.5
	syntaxin 12. [refseq;acc:nm_177424]	Divided	208.997	217.446	1.04043
859	60s ribosomal protein l39. [swissprot;acc:p02404]		224.958	234.025	1.04031
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	42.3003	50.7983	8.498
860	60s ribosomal protein l18a. [swissprot;acc:q02543]	Divided	224.958	234.025	1.04031
	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Subtracted	233.544	242.024	8.48
861	40s ribosomal protein s19. [swissprot;acc:p39019]	Divided	224.958	234.025	1.04031
	syntaxin 12. [refseq;acc:nm_177424]	Subtracted	208.997	217.446	8.449
862	60s ribosomal protein l31. [swissprot;acc:p12947]	Divided	224.958	234.025	1.04031
	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	Subtracted	239.778	231.357	8.421
863	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	Divided	230.957	240.194	1.03999
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Subtracted	206.623	215.028	8.405
864	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	Divided	230.957	240.194	1.03999
	exocyst complex component sec8. [swissprot;acc:q96a65]	Subtracted	209.449	217.762	8.313
865	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Divided	203.814	211.961	1.03997
	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	Subtracted	278.239	269.963	8.276
866	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Divided	212.806	221.306	1.03994
	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	Subtracted	278.232	269.96	8.272
867	40s ribosomal protein s3a. [swissprot;acc:p49241]	Divided	234.674	225.689	1.03981
	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	Subtracted	278.223	269.956	8.267
868	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	Divided	242.571	233.298	1.03975
	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Subtracted	278.223	269.956	8.267
869	exocyst complex component sec8. [swissprot;acc:q96a65]	Divided	209.449	217.762	1.03969
	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	Subtracted	278.221	269.955	8.266
870	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Divided	203.832	211.908	1.03962
	zinc finger protein 305. [swissprot;acc:o43309]	Subtracted	278.219	269.954	8.265
871	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	114.552	110.2	1.03949
	zinc finger protein 232. [swissprot;acc:q9uny5]	Subtracted	278.218	269.954	8.264
872	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	Divided	233.272	224.413	1.03948
	zinc finger protein 99. [refseq;acc:nm_032164]	Subtracted	278.218	269.954	8.264
873	u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]	Divided	233.272	224.413	1.03948
	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	Subtracted	278.217	269.954	8.263
874	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	Divided	203.954	212.002	1.03946
	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	Subtracted	278.215	269.953	8.262
875	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Divided	203.954	212.002	1.03946
	junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923]	Subtracted	215.653	223.906	8.253
876	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	Divided	203.954	212.002	1.03946
	tax interaction protein 1. [refseq;acc:nm_014604]	Subtracted	215.653	223.906	8.253
877	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	Divided	203.954	212.002	1.03946
	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	Subtracted	278.093	269.896	8.197
878	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	Divided	203.954	212.002	1.03946
	syntaxin 7. [swissprot;acc:o15400]	Subtracted	209.012	217.181	8.169
879	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	Divided	203.954	212.002	1.03946
	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	Subtracted	209.323	217.491	8.168
880	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Divided	203.954	212.002	1.03946
	phenylalanine-trna synthetase. [refseq;acc:nm_006567]	Subtracted	209.323	217.491	8.168
881	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	Divided	219.001	227.604	1.03928
	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Subtracted	203.814	211.961	8.147

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.