Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Hugo description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 3814 to 3863 of 6456 in total
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1
Rank
Hugo
description
Network Comparison Type
red
green
network_comparison
1907 SLC27A5 solute carrier family 27 (fatty acid transporter), member 5; very long-chain acyl-coa synthetase homolog 2; very long-chain acyl-coa synthetase-related protein; likely ortholog of mouse solute carrier family 27 (fatty acid transporter), member 5. [refseq;acc:nm_012254] Divided 191.408 193.387 1.01034
1908 ADD1 alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611] Subtracted 224.432 222.258 2.174
DIP2B similar to cg7020 gene product (fragment). [sptrembl;acc:q96ib4] Divided 191.415 193.394 1.01034
1909 CLGN calmegin precursor. [swissprot;acc:o14967] 217.48 215.256 1.01033
NME3 nucleoside diphosphate kinase 3 (ec 2.7.4.6) (ndk 3) (ndp kinase 3) (nm23-h3) (dr-nm23). [swissprot;acc:q13232] Subtracted 191.39 189.219 2.171
1910 ARG2 arginase ii, mitochondrial precursor (ec 3.5.3.1) (non-hepatic arginase) (kidney-type arginase). [swissprot;acc:p78540] 204.512 206.682 2.17
CANX calnexin precursor (major histocompatibility complex class i antigen-binding protein p88) (p90) (ip90). [swissprot;acc:p27824] Divided 217.48 215.256 1.01033
1911 OTC ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480] Subtracted 215.667 217.82 2.153
SEPSECS soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825] Divided 217.48 215.256 1.01033
1912 ABHD2 abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910] Subtracted 218.43 216.279 2.151
RNMT rna (guanine-7-) methyltransferase. [refseq;acc:nm_003799] Divided 217.48 215.256 1.01033
1913 no value phospholipid scramblase 3 (pl scramblase 3) (ca(2+)-dependent phospholipid scramblase 3). [swissprot;acc:q9nry6] 215.745 213.564 1.01021
QKI quaking isoform 6. [sptrembl;acc:q9p0x9] Subtracted 218.43 216.279 2.151
1914 no value 3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362] 196.008 198.154 2.146
PLSCR4 phospholipid scramblase 4 (pl scramblase 4) (ca(2+)-dependent phospholipid scramblase 4). [swissprot;acc:q9nrq2] Divided 215.745 213.564 1.01021
1915 PLSCR2 phospholipid scramblase 2 (pl scramblase 2) (ca(2+)-dependent phospholipid scramblase 2). [swissprot;acc:q9nry7] 215.747 213.571 1.01019
RBPMS rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062] Subtracted 218.794 216.663 2.131
1916 LIN7A lin-7 homolog a; vertebrate lin7 homolog 1; tax interaction protein 33; mammalian lin-7 1. [refseq;acc:nm_004664] 225.022 222.9 2.122
RHCG rh type c glycoprotein. [refseq;acc:nm_016321] Divided 196.88 198.88 1.01016
1917 ING5 p28 ing5. [refseq;acc:nm_032329] 215.848 218.039 1.01015
SEC16B regucalcin gene promotor region related protein; rgpr-p117. [refseq;acc:nm_033127] Subtracted 219.777 217.659 2.118
1918 MED28 endothelial-derived gene 1. [refseq;acc:nm_025205] Divided 202.211 200.18 1.01015
VPS18 vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253] Subtracted 215.847 213.747 2.1
1919 HARS2 histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590] Divided 187.231 185.349 1.01015
NFIL3 nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384] Subtracted 214.234 212.142 2.092
1920 no value 15 kda selenoprotein precursor. [swissprot;acc:o60613] 214.522 212.432 2.09
HARS histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081] Divided 187.292 185.413 1.01013
1921 KPNA1 importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294] Subtracted 211.647 213.724 2.077
MTR 5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707] Divided 221.607 219.386 1.01012
1922 CENTG2 centaurin gamma 2. [swissprot;acc:q9upq3] 220.659 218.452 1.0101
PDLIM5 lim protein (similar to rat protein kinase c-binding enigma); enigma homolog. [refseq;acc:nm_006457] Subtracted 219.25 217.175 2.075
1923 LIN7B lin-7 homolog b; lin-7b protein; likely ortholog of mouse lin-7b; mammalian lin-7 protein 2; likely orholog of mouse lin 7 homolog b (c. elegans). [refseq;acc:nm_022165] 225.02 222.948 2.072
USO1 general vesicular transport factor p115 (transcytosis associated protein) (tap) (vesicle docking protein). [swissprot;acc:o60763] Divided 220.659 218.452 1.0101
1924 CENTG1 centaurin gamma 1. [swissprot;acc:q99490]
KCNAB3 voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448] Subtracted 211.632 213.703 2.071
1925 CENTG3 centaurin gamma 3. [swissprot;acc:q96p47] Divided 220.659 218.452 1.0101
YIF1A yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470] Subtracted 211.633 213.703 2.07
1926 KCNAB1 voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]
RHBG rhesus blood group, b glycoprotein; rh type b glycoprotein. [refseq;acc:nm_020407] Divided 196.925 198.91 1.01008
1927 RHAG rhesus blood group-associated glycoprotein (erythrocyte plasma membrane 50 kda glycoprotein) (rh50a). [swissprot;acc:q02094] 196.932 198.914 1.01006
YIF1B similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557] Subtracted 211.633 213.703 2.07
1928 AKR7A3 aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]
RHD blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161] Divided 196.964 198.935 1.01001
1929 no value enigma protein; lim domain protein. [refseq;acc:nm_005451] 219.753 217.574
ABHD3 alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340] Subtracted 211.633 213.703 2.07
1930 no value blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577] Divided 196.964 198.935 1.01001
YIPF5 golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799] Subtracted 211.633 213.703 2.07
1931 ABHD1 alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
EIF3D eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371] Divided 219.753 217.574 1.01001
1932 no value blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577] 196.965 198.936

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/