MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Value Type	Network Comparison Type	Rank	network_comparison	Interaction Map	red	description	green	Filtered

Results: HTML CSV LaTeX

Showing element 1677 to 1726 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	network_comparison	red	description	green
1677	1.06937	6075.19	ribonuclease hi large subunit (ec 3.1.26.-) (rnase hi large subunit) (rnase h(35)) (ribonuclease h2) (rnase h2). [swissprot;acc:o75792]	6496.61
1678	1.06936	5763.25	cleavage and polyadenylation specific factor 5, 25 kd subunit; pre-mrna cleavage factor im (25kd); pre-mrna cleavage factor im, 25kd subunit. [refseq;acc:nm_007006]	6162.98
1679	1.06923	6180.24	proteasome subunit beta type 3 (ec 3.4.25.1) (proteasome theta chain) (proteasome chain 13) (proteasome component c10-ii). [swissprot;acc:p49720]	6608.11
1680	1.0692	6436.73	methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898]	6882.16
1681	1.06914	6304.74	f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	6740.66
1682			f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]
1683	1.06908	5419.54	ring finger protein 20. [refseq;acc:nm_019592]	5793.94
1684			ring finger protein 40; 95 kda retinoblastoma protein binding protein; likely ortholog of rat staring. [refseq;acc:nm_014771]
1685	1.06905	6088.07	gc-rich sequence dna-binding factor homolog. [swissprot;acc:q9y5b6]	6508.45
1686			toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]
1687	1.06904	5767.69	serpin b12. [swissprot;acc:q96p63]	6165.87
1688			megsin (tp55) (serpin b7). [swissprot;acc:o75635]
1689			hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]
1690			oxysterols receptor lxr-beta (liver x receptor beta) (nuclear orphan receptor lxr-beta) (ubiquitously-expressed nuclear receptor) (nuclear receptor ner). [swissprot;acc:p55055]
1691			upf0183 protein. [swissprot;acc:q9bsu1]
1692			antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]
1693			translation initiation factor eif-2b alpha subunit (eif-2b gdp-gtp exchange factor). [swissprot;acc:q14232]
1694			squamous cell carcinoma antigen 1 (scca-1) (protein t4-a). [swissprot;acc:p29508]
1695			oxysterols receptor lxr-alpha (liver x receptor alpha) (nuclear orphan receptor lxr-alpha). [swissprot;acc:q13133]
1696	1.06893	6304.22	wiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (verprolin homology domain-containing protein 2). [swissprot;acc:q9y6w5]	6738.77
1697		6304.21	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]
1698		6304.22	wiskott-aldrich syndrome protein family member 1 (wasp-family protein member 1) (verprolin homology domain-containing protein 1). [swissprot;acc:q92558]
1699		6304.21	rest corepressor. [refseq;acc:nm_015156]
1700	1.06892	6326.24	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing gamma polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-gamma) (ptdins-3-kinase c2 gamma) (pi3k-c2gamma). [swissprot;acc:o75747]	6762.27
1701			phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]
1702			dynamin 1-like protein isoform 3; dynamin-like protein. [refseq;acc:nm_005690]
1703			phosphoinositide-3-kinase, class 2, alpha polypeptide; c2-containing phosphatidylinositol kinase. [refseq;acc:nm_002645]
1704	1.06883	5778.4	homeobox protein six1 (sine oculis homeobox homolog 1). [swissprot;acc:q15475]	6176.13
1705	1.06878	5369.43	translation initiation factor eif-2b epsilon subunit (eif-2b gdp-gtp exchange factor). [swissprot;acc:q13144]	5738.73
1706			translation initiation factor eif-2b gamma subunit (eif-2b gdp-gtp exchange factor). [swissprot;acc:q9nr50]
1707	1.06873	5777.1	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	6174.15
1708	1.06868	7033.72	metaxin 2. [swissprot;acc:o75431]	7516.77
1709	1.06861	5775.55	homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	6171.79
1710	1.06857	5916.13	camp-dependent protein kinase type ii-alpha regulatory chain. [swissprot;acc:p13861]	6321.77
1711	1.06853	5917.22	protein kinase pkx1 (ec 2.7.1.-). [swissprot;acc:p51817]	6322.72
1712		5917.23	camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612]	6322.73
1713			camp-dependent protein kinase, beta-catalytic subunit (ec 2.7.1.37) (pka c-beta). [swissprot;acc:p22694]
1714			camp-dependent protein kinase, alpha-catalytic subunit (ec 2.7.1.37) (pka c-alpha). [swissprot;acc:p17612]
1715	1.06849	5918.48	camp-dependent protein kinase type ii-beta regulatory chain. [swissprot;acc:p31323]	6323.83
1716	1.06844	6070.41	inositol-1(or 4)-monophosphatase 2 (ec 3.1.3.25) (impase 2) (imp 2) (inositol monophosphatase 2) (myo-inositol monophosphatase a2). [swissprot;acc:o14732]	6485.85
1717	1.06842	6069.65	inositol-1(or 4)-monophosphatase (ec 3.1.3.25) (impase) (imp) (inositol monophosphatase) (lithium-sensitive myo-inositol monophosphatase a1). [swissprot;acc:p29218]	6484.94
1718	1.06831	9720.64	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]	9099.1
1719	1.06827	5458.12	mannose-6-phosphate isomerase (ec 5.3.1.8) (phosphomannose isomerase) (pmi) (phosphohexomutase). [swissprot;acc:p34949]	5830.76
1720			putative ankyrin-repeat containing protein. [refseq;acc:nm_025185]
1721			mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]
1722			protocadherin fat 2 precursor (hfat2) (multiple epidermal growth factor-like domains 1). [swissprot;acc:q9nyq8]
1723			cadherin-related tumor suppressor homolog precursor (fat protein homolog). [swissprot;acc:q14517]
1724			mln64 n-terminal domain homolog (stard3 n-terminal like protein). [swissprot;acc:o95772]
1725	1.06818	6051.06	glucose-6-phosphate isomerase (ec 5.3.1.9) (gpi) (phosphoglucose isomerase) (pgi) (phosphohexose isomerase) (phi) (neuroleukin) (nlk) (sperm antigen-36) (sa-36). [swissprot;acc:p06744]	6463.65
1726	1.0679	7048.79	peroxisomal 3,2-trans-enoyl-coa isomerase (ec 5.3.3.8) (dodecenoyl-coa delta-isomerase) (d3,d2-enoyl-coa isomerase) (dbi-related protein 1) (drs-1) (hepatocellular carcinoma-associated antigen 88). [swissprot;acc:o75521]	7527.42

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.