MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Gene	Value Type	description	Rank	network_comparison	green	Filtered	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 1663 to 1712 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	green	red
mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]	820	1.04413	231.501	221.716
mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]	2607	1.0014	215.799	215.497
mitochondrial 28s ribosomal protein s30 (s30mt) (mrp-s30) (programmed cell death protein 9) (bm047). [swissprot;acc:q9np92]	3063	1	0.00001	0.00001
mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	996	1.03345	212.547	219.656
mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]	2825	1	0.00001	0.00001
mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	955	1.03479	239.205	231.163
mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	318	1.09987	266.18	242.011
mitochondrial deoxynucleotide carrier (mitochondrial uncoupling protein 1). [swissprot;acc:q9hc21]	3014	1	0.00001	0.00001
mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	698	1.05413	209.118	220.437
mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	1095	1.02935	207.463	213.552
mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	730	1.05187	219.708	208.874
mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	455	1.07779	226.578	210.225
mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	840	1.04259	190.66	198.781
mitochondrial precursor proteins import receptor (translocase of outer membrane tom70). [swissprot;acc:o94826]	2610	1.0014	215.799	215.497
mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713]	1300	1.02379	212.576	217.634
mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439]	1299	1.0238	212.575	217.635
mitochondrial ribosomal protein l17; lyst-interacting protein lip2. [refseq;acc:nm_022061]	361	1.09644	266.248	242.83
mitochondrial ribosomal protein l18. [refseq;acc:nm_014161]	2246	1.0061	224.943	223.58
mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	305	1.1017	266.986	242.339
mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]	487	1.07387	243.03	226.313
mitochondrial ribosomal protein l24. [refseq;acc:nm_024540]	1985	1.00952	217.193	219.26
mitochondrial ribosomal protein l30 isoform a. [refseq;acc:nm_145212]	2477	1.00289	216.801	216.177
mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	296	1.10294	266.12	241.282
mitochondrial ribosomal protein s7; 30s ribosomal protein s7 homolog. [refseq;acc:nm_015971]	3016	1	0.00001	0.00001
mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	663	1.0577	216.576	229.072
mitochondrial solute carrier protein. [refseq;acc:nm_016612]	2915	1	0.00001	0.00001
mitochondrial solute carrier protein. [refseq;acc:nm_145305]	27	1.31818	44	58
mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	932	1.03636	218.013	225.939
mitogen-activated protein kinase 1 (ec 2.7.1.37) (extracellular signal-regulated kinase 2) (erk-2) (mitogen-activated protein kinase 2) (map kinase 2) (mapk 2) (p42-mapk) (ert1). [swissprot;acc:p28482]	2168	1.00673	214.486	215.929
mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	1263	1.02425	167.177	171.231
mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	1274
mitogen-activated protein kinase 3 (ec 2.7.1.37) (extracellular signal-regulated kinase 1) (erk-1) (insulin-stimulated map2 kinase) (map kinase 1) (mapk 1) (p44-erk1) (ert2) (p44-mapk) (microtubule- associated protein-2 kinase). [swissprot;acc:p27361]	2159	1.00675	214.474	215.921
mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [swissprot;acc:q9uha4]	3084	1	0.00001	0.00001
mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk kinase kinase 5) (mek kinase 5) (mekk 5) (apoptosis signal- regulating kinase 1) (ask-1). [swissprot;acc:q99683]	2174	1.00673	214.481	215.925
mitogen-activated protein kinase kinase kinase 6 (ec 2.7.1.-). [swissprot;acc:o95382]	2163
mitogen-activated protein kinase kinase kinase 7 (ec 2.7.1.-) (transforming growth factor-beta-activated kinase 1) (tgf-beta- activated kinase 1). [swissprot;acc:o43318]	1489	1.01905	209.264	213.251
mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (tak1-binding protein 1). [swissprot;acc:q15750]	2273	1.00546	211.858	213.015
mitogen-activated protein kinase kinase kinase 7 interacting protein 2 isoform 1; tak1-binding protein 2. [refseq;acc:nm_015093]	2342	1.00452	230.294	229.258
mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	1273	1.02425	167.177	171.231
mitotic checkpoint protein bub3. [swissprot;acc:o43684]	1632	1.01498	218.658	221.934
mitotic checkpoint serine/threonine-protein kinase bub1 beta (ec 2.7.1.-) (hbubr1) (mad3/bub1-related protein kinase) (mitotic checkpoint kinase mad3l). [swissprot;acc:o60566]	1707	1.01351	218.334	221.283
mitotic spindle assembly checkpoint protein mad2a (mad2-like 1) (hsmad2). [swissprot;acc:q13257]	2265	1.00561	210.416	211.597
mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	995	1.03345	212.547	219.656
mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	462	1.07709	236.224	254.434
mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	1524	1.01766	223.179	219.306
mln64 n-terminal domain homolog (stard3 n-terminal like protein). [swissprot;acc:o95772]	1527
mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	2270	1.00554	208.69	207.54
mo25 protein (cgi-66). [swissprot;acc:q9y376]	2976	1	0.00001	0.00001
mo25-like protein. [swissprot;acc:q9h9s4]	3116
mob-lak. [refseq;acc:nm_130807]	2812

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.