Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison

Results: HTML CSV LaTeX

Showing element 1575 to 1624 of 6456 in total

Value Type	Ranked
Interaction Map	High confidence
Filtered	1

Rank	description	Network Comparison Type	red	green	network_comparison	
788	hira-interacting protein 5 (cgi-33). [source:swissprot;acc:q9ums0]	Divided	138.705	132.538	1.04653	
788	loh1cr12. [source:refseq;acc:nm_058169]	Subtracted	230.087	220.579	9.508	
789	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [source:swissprot;acc:p08865]	Divided	224.244	234.511	1.04578	
789	unr protein. [source:swissprot;acc:o75534]	Subtracted	230.087	220.579	9.508	
790	40s ribosomal protein s21. [source:swissprot;acc:p35265]	Divided	224.244	234.511	1.04578	
790	testis-specific protein tex28. [source:swissprot;acc:o15482]	Subtracted	212.386	221.785	9.399	
791	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [source:swissprot;acc:p50453]	Divided	224.244	234.511	1.04578	
791	similar to nuclear protein e3-3 orf1. [source:sptrembl;acc:q9bu61]	Subtracted	212.386	221.785	9.399	
792	a kindred of iglon. [source:refseq;acc:nm_173808]	Subtracted	212.386	221.785	9.399	
792	maspin precursor (protease inhibitor 5). [source:swissprot;acc:p36952]	Divided	224.244	234.511	1.04578	
793	ankyrin-repeat family a protein 2 (rfxank-like 2). [source:swissprot;acc:q9h9e1]	Subtracted	212.386	221.785	9.399	
793	bomapin (protease inhibitor 10) (serpin b10). [source:swissprot;acc:p48595]	Divided	224.244	234.511	1.04578	
794	inflammation-related g protein-coupled receptor ex33. [source:refseq;acc:nm_020370]	Subtracted	212.386	221.785	9.399	
794	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [source:swissprot;acc:p05120]	Divided	224.244	234.511	1.04578	
795	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [source:swissprot;acc:p50897]	Subtracted	212.386	221.785	9.399	
795	serpin b11. [source:swissprot;acc:q96p15]	Divided	224.244	234.511	1.04578	
796	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [source:swissprot;acc:q9h115]	Subtracted	212.386	221.785	9.399	
796	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [source:swissprot;acc:p35237]	Divided	224.244	234.511	1.04578	
797	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [source:swissprot;acc:p50452]	Divided	224.244	234.511	1.04578	
797	syntaxin 16 (syn16). [source:swissprot;acc:o14662]	Subtracted	212.386	221.785	9.399	
798	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [source:swissprot;acc:o14653]	Subtracted	212.386	221.785	9.399	
798	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [source:swissprot;acc:p30740]	Divided	224.244	234.511	1.04578	
799	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [source:refseq;acc:nm_003900]	Divided	221.965	212.404	1.04501	
799	syntaxin 1a (neuron-specific antigen hpc-1). [source:swissprot;acc:q16623]	Subtracted	212.386	221.785	9.399	
800	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [source:swissprot;acc:p54920]	Subtracted	212.386	221.785	9.399	
800	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [source:swissprot;acc:p22307]	Divided	221.965	212.404	1.04501	
801	adipocyte plasma membrane-associated protein (bscv protein). [source:swissprot;acc:q9hdc9]	Subtracted	212.386	221.785	9.399	
801	beta-catenin (pro2286). [source:swissprot;acc:p35222]	Divided	224.445	214.894	1.04445	
802	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [source:swissprot;acc:o95721]	Subtracted	212.386	221.785	9.399	
802	testis-specific protein tex28. [source:swissprot;acc:o15482]	Divided	212.386	221.785	1.04425	
803	similar to nuclear protein e3-3 orf1. [source:sptrembl;acc:q9bu61]	Divided	212.386	221.785	1.04425	
803	syntaxin 1b. [source:swissprot;acc:q15531]	Subtracted	212.386	221.785	9.399	
804	a kindred of iglon. [source:refseq;acc:nm_173808]	Divided	212.386	221.785	1.04425	
804	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [source:swissprot;acc:q13084]	Subtracted	212.386	221.785	9.399	
805	ankyrin-repeat family a protein 2 (rfxank-like 2). [source:swissprot;acc:q9h9e1]	Divided	212.386	221.785	1.04425	
805	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [source:swissprot;acc:o14593]	Subtracted	212.386	221.785	9.399	
806	inflammation-related g protein-coupled receptor ex33. [source:refseq;acc:nm_020370]	Divided	212.386	221.785	1.04425	
806	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [source:swissprot;acc:o43708]	Subtracted	267.447	276.773	9.326	
807	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [source:swissprot;acc:p50897]	Divided	212.386	221.785	1.04425	
807	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [source:swissprot;acc:p22102]	Subtracted	218.521	227.796	9.275	
808	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [source:swissprot;acc:q92993]	Subtracted	223.186	213.912	9.274	
808	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [source:swissprot;acc:q9h115]	Divided	212.386	221.785	1.04425	
809	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [source:swissprot;acc:p53602]	Subtracted	233.298	242.571	9.273	
809	syntaxin 16 (syn16). [source:swissprot;acc:o14662]	Divided	212.386	221.785	1.04425	
810	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [source:swissprot;acc:o14653]	Divided	212.386	221.785	1.04425	
810	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [source:swissprot;acc:p19138]	Subtracted	240.194	230.957	9.237	
811	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [source:swissprot;acc:p19784]	Subtracted	240.194	230.957	9.237	
811	syntaxin 1a (neuron-specific antigen hpc-1). [source:swissprot;acc:q16623]	Divided	212.386	221.785	1.04425	
812	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [source:swissprot;acc:p54920]	Divided	212.386	221.785	1.04425	
812	putatative 28 kda protein. [source:refseq;acc:nm_020143]	Subtracted	227.241	236.467	9.226	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/