MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1551 to 1600 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

description	Rank	Network Comparison Type	Filtered	red	green	network_comparison
cyclin m2; ancient conserved domain protein 2. [refseq;acc:nm_017649]	2604	Divided	1	214.486	214.184	1.00141
	2618	Subtracted				0.302
cyclin m3; ancient conserved domain protein 3. [refseq;acc:nm_017623]	2601	Divided		214.502	214.2	1.00141
	2614	Subtracted				0.302
cyclin m4; ancient conserved domain protein 4. [refseq;acc:nm_020184]	2603	Divided		214.494	214.192	1.00141
	2616	Subtracted				0.302
cyclin t1 (cyclin t) (cyct1). [swissprot;acc:o60563]	3002	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
cyclin t2. [swissprot;acc:o60583]	3171	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
cyclin-dependent kinase (cdc2-like) 11; death-preventing kinase. [refseq;acc:nm_015076]	2892	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	169			312	284	28
	336	Divided				1.09859
cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	186	Subtracted	0	12677.7	13941.7	1264
	238	Divided				1.0997
	1452		1	160.381	163.554	1.01978
	1638	Subtracted				3.173
cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552]	1833	Divided		180.409	182.459	1.01136
	1955	Subtracted				2.05
cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]	423	Divided	0	5905	6073	1.02845
	459	Subtracted				168
	2560		1	219.907	220.267	0.36
	2570	Divided				1.00164
cyr61 protein precursor (cysteine-rich, angiogenic inducer, 61) (insulin-like growth factor-binding protein 10) (gig1 protein). [swissprot;acc:o00622]	2938			0.00001	0.00001	1
		Subtracted		0	0	0
cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]	1022	Divided		205.632	199.266	1.03195
	1045	Subtracted				6.366
cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	60			269.254	327.655	58.401
	121	Divided				1.2169
cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	14			56.6768	75.3531	1.32952
	161		0	5781.93	6660.63	1.15197
	271	Subtracted				878.7
	387		1	56.6768	75.3531	18.6763
cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	17	Divided		56.7841	75.447	1.32866
	159		0	5813.32	6706.32	1.15361
	266	Subtracted				893
	390		1	56.7841	75.447	18.6629
cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	1531	Divided		217.025	213.304	1.01744
	1537	Subtracted				3.721
cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	144			239.35	267.915	28.565
	230	Divided				1.11934
cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]	1369	Subtracted		221.152	216.659	4.493
	1423	Divided				1.02074
cysteine-rich secretory protein-1 precursor (crisp-1) (acidic epididymal glycoprotein homolog) (aeg-like protein) (arp). [swissprot;acc:p54107]	3018			0.00001	0.00001	1
		Subtracted		0	0	0
cysteine-rich secretory protein-3 precursor (crisp-3) (sgp28 protein). [swissprot;acc:p54108]	3150	Divided		0.00001	0.00001	1
		Subtracted		0	0	0
cytidine deaminase (ec 3.5.4.5) (cytidine aminohydrolase). [swissprot;acc:p32320]	1838			220.852	223.225	2.373
	1880	Divided				1.01074

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.