MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Rank	Network Comparison Type	Value Type	green	Interaction Map	description	network_comparison	red	Filtered

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	green	description	network_comparison	red
1458	211.086	eh-domain containing protein 3. [swissprot;acc:q9nzn3]	1.01962	207.024
1459	188.637	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	1.01961	192.336
1460	209.851	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	1.0196	205.817
1461	211.077	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]		207.019
1462	209.851	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (e2) (e2k). [swissprot;acc:p36957]		205.817
1463	164.211	pnas-18. [sptrembl;acc:q9bzu3]	1.01959	161.056
1464	213.18	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	1.01957	217.351
1465		mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]
1466	211.073	reticulon protein 2 (neuroendocrine-specific protein-like 1) (nsp-like protein 1) (nspli). [swissprot;acc:o75298]		207.022
1467	232.983	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	1.01956	228.513
1468	207.937	dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]	1.01954	212.001
1469	211.05	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	1.0195	207.013
1470	217.199	glutaminyl-trna synthetase (ec 6.1.1.18) (glutamine--trna ligase) (glnrs). [swissprot;acc:p47897]	1.0194	221.412
1471		spermidine synthase (ec 2.5.1.16) (putrescine aminopropyltransferase) (spdsy). [swissprot;acc:p19623]
1472		glycyl-trna synthetase (ec 6.1.1.14) (glycine--trna ligase) (glyrs). [swissprot;acc:p41250]
1473		glutamyl trna synthetase. [sptrembl;acc:o14563]
1474	214.427	importin beta-3 subunit (karyopherin beta-3 subunit) (ran-binding protein 5). [swissprot;acc:o00410]	1.01938	218.582
1475	178.438	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]	1.0193	181.882
1476	214.457	ran-gtp binding protein (fragment). [sptrembl;acc:o60518]	1.01928	218.591
1477	211.267	transformer-2 protein homolog (tra-2 alpha). [swissprot;acc:q13595]	1.01922	215.328
1478	211.066	arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]		215.122
1479	232.855	maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5]	1.0192	228.469
1480	214.55	cleavage and polyadenylation specific factor 6, 68 kd subunit; pre-mrna cleavage factor im (68kd); cleavage and polyadenylation specific factor 6, 68kd subunit; pre-mrna cleavage factor i, 68kd subunit. [refseq;acc:nm_007007]	1.01918	218.664
1481	204.516	cell division cycle protein 23; anaphase-promoting complex subunit 8. [refseq;acc:nm_004661]	1.01915	208.432
1482	220.15	limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	1.0191	224.354
1483	202.726	pyruvate dehydrogenase e1 component beta subunit, mitochondrial precursor (ec 1.2.4.1) (pdhe1-b). [swissprot;acc:p11177]		198.927
1484		2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]
1485	203.989	j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330]	1.01906	207.877
1486		human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]
1487		zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822]
1488		human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]
1489	209.264	mitogen-activated protein kinase kinase kinase 7 (ec 2.7.1.-) (transforming growth factor-beta-activated kinase 1) (tgf-beta- activated kinase 1). [swissprot;acc:o43318]	1.01905	213.251
1490	226.186	protein cgi-147. [swissprot;acc:q9y3e5]	1.01903	221.961
1491	221.839	glucose-6-phosphate isomerase (ec 5.3.1.9) (gpi) (phosphoglucose isomerase) (pgi) (phosphohexose isomerase) (phi) (neuroleukin) (nlk) (sperm antigen-36) (sa-36). [swissprot;acc:p06744]	1.01899	217.704
1492	220.017	opioid binding protein/cell adhesion molecule precursor (obcam) (opioid-binding cell adhesion molecule) (opcml). [swissprot;acc:q14982]	1.01883	224.159
1493	207.988	pyruvate dehydrogenase e1 component alpha subunit, testis-specific form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type ii). [swissprot;acc:p29803]	1.01882	204.146
1494	207.967	pyruvate dehydrogenase e1 component alpha subunit, somatic form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type i). [swissprot;acc:p08559]	1.01878	204.133
1495	225.237	casein kinase i alpha s-like. [refseq;acc:nm_145203]	1.01874	229.459
1496		casein kinase i, alpha isoform (ec 2.7.1.-) (cki-alpha) (ck1). [swissprot;acc:p48729]
1497	220.363	exportin 1; exportin-1 (required for chromosome region maintenance); exportin 1 (crm1, yeast, homolog); crm1, yeast, homolog. [refseq;acc:nm_003400]	1.01866	224.476
1498	219.924	neurotrimin precursor (hnt). [swissprot;acc:q9p121]	1.01863	224.022
1499	220.411	transcription factor smif; decapping enzyme hdcp1a. [refseq;acc:nm_018403]	1.01859	224.509
1500	209.52	cop9 complex subunit 4; likely ortholog of mouse cop9 (constitutive photomorphogenic), subunit 4 (arabidopsis); cop9 (constitutive photomorphogenic, arabidopsis, homolog) subunit 4. [refseq;acc:nm_016129]	1.01851	213.398
1501	210.838	kinesin family member c3. [refseq;acc:nm_005550]	1.01845	214.727
1502	214.149	uridine kinase-like 1. [swissprot;acc:q9nwz5]	1.01838	218.084
1503	237.834	hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]	1.01828	242.181
1504	254.797	m-phase inducer phosphatase 3 (ec 3.1.3.48) (dual specificity phosphatase cdc25c). [swissprot;acc:p30307]	1.01822	259.439
1505	212.316	protein ad-016 (protein cgi-116) (x0009). [swissprot;acc:q9y3c0]	1.0181	216.158
1506	208.339	c316g12.2 (novel protein similar to predicted yeast, worm and archae- bacterial proteins) (similar to und313) (s. cervisiae) (hypothetical protein). [sptrembl;acc:q9ujk0]	1.01807	212.103
1507	209.5	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	1.01801	213.274

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.