Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank description Network Comparison Type Value Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1375 to 1424 of 6456 in total
Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Network Comparison Type
red
green
network_comparison
688 5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131] Divided 6920.67 7747.6 1.11949
retinoblastoma-like protein 1 (107 kda retinoblastoma-associated protein) (prb1) (p107). [swissprot;acc:p28749] Subtracted 6311.83 6989.6 677.77
689 5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741] Divided 6920.69 7747.63 1.11949
retinoblastoma-like protein 2 (130 kda retinoblastoma-associated protein) (prb2) (p130) (rbr-2). [swissprot;acc:q08999] Subtracted 6311.6 6989.33 677.73
690 5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9] Divided 6920.69 7747.63 1.11949
trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646] Subtracted 6257.99 6932.95 674.96
691 5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478] Divided 6920.69 7747.63 1.11949
t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643] Subtracted 8425.35 7751.57 673.78
692 5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0] Divided 6920.69 7747.63 1.11949
e-1 enzyme. [refseq;acc:nm_021204] Subtracted 6603.09 7274.72 671.63
693 eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010] 3199.4 3870.8 671.4
j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330] Divided 7725.1 8647.74 1.11943
694 human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]
orphan nuclear receptor nr6a1 (germ cell nuclear factor) (gcnf) (retinoid receptor-related testis specific receptor) (rtr). [swissprot;acc:q15406] Subtracted 6075.55 6746.92 671.37
695 vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449] 5768.32 6434.78 666.46
zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822] Divided 7725.1 8647.74 1.11943
696 human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]
sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167] Subtracted 5768.32 6434.78 666.46
697 golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
sh3-containing grb2-like protein 2 (sh3 domain protein 2a) (endophilin 1) (een-b1). [swissprot;acc:q99962] Divided 7105.27 7953.71 1.11941
698 armet protein precursor (arginine-rich protein). [swissprot;acc:p55145] 7101.95 7949.85 1.11939
delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629] Subtracted 5768.32 6434.78 666.46
699 cellular modulator of immune recognition. [refseq;acc:nm_145021]
histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113] Divided 7101.94 7949.84 1.11939
700 40s ribosomal protein s28. [swissprot;acc:p25112] 7161.14 8015.92 1.11936
vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437] Subtracted 5768.32 6434.78 666.46
701 gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]
importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060] Divided 7802.31 8731.82 1.11913
702 sh3-containing grb2-like protein 3 (sh3 domain protein 2c) (een-b2). [swissprot;acc:q99963] 7067.46 7909.27 1.11911
sprouty homolog 4 (spry-4). [swissprot;acc:q9c004] Subtracted 5549.2 6215.42 666.22
703 nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594] Divided 6912.56 7735.12 1.11899
sprouty homolog 3 (spry-3). [swissprot;acc:o43610] Subtracted 5549.2 6215.42 666.22
704 alpha-nac protein. [sptrembl;acc:q9h009] Divided 6912.27 7734.68 1.11898
sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609] Subtracted 5549.2 6215.42 666.22
705 small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173] Divided 6912.09 7734.41 1.11897
sprouty homolog 2 (spry-2). [swissprot;acc:o43597] Subtracted 5549.2 6215.42 666.22
706 di-ras2. [refseq;acc:nm_017594] Divided 6912.08 7734.39 1.11897
syntaxin 12. [refseq;acc:nm_177424] Subtracted 5552.92 6217.59 664.67
707 atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565] 5870.2 6533.39 663.19
c18b11 homolog (44.9kd). [refseq;acc:nm_152260] Divided 5317.78 5944.25 1.11781
708 protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688] Subtracted 4775.11 5438.18 663.07
z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24] Divided 5317.78 5944.25 1.11781
709 dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409] Subtracted 5148.71 5811.74 663.03
pp1201 protein. [refseq;acc:nm_022152] Divided 5317.78 5944.25 1.11781
710 kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592] Subtracted 2755.15 2094.3 660.85
lifeguard; kiaa0950 protein. [refseq;acc:nm_012306] Divided 5317.78 5944.25 1.11781
711 potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183] Subtracted 2759.61 2099.49 660.12
sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772] Divided 5317.78 5944.25 1.11781
712 kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193] Subtracted 2760.28 2100.27 660.01
sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956] Divided 5317.78 5944.25 1.11781

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/