MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Network Comparison Type	Value Type	Gene	description	Rank	Filtered	Interaction Map	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1325 to 1374 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence

description	Rank	network_comparison	red	green
homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	7	1.49767	215	322
homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	614	1.06002	214.257	202.125
homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	686	1.05602	132.413	125.389
homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	685
homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	616	1.05999	214.257	202.132
homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	680	1.05602	132.413	125.389
homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	684
homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	615	1.05999	214.257	202.132
homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	679	1.05602	132.413	125.389
homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	681
homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	682
homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	617	1.05997	214.257	202.135
homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	683	1.05602	132.413	125.389
homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	632	1.05979	214.254	202.166
homeobox protein meis1. [swissprot;acc:o00470]	1783	1.01206	206.332	203.874
homeobox protein meis2 (meis1-related protein 1). [swissprot;acc:o14770]	1784
homeobox protein meis3 (meis1-related protein 2) (fragment). [swissprot;acc:q99687]	1788
homeobox protein nkx-6.1. [swissprot;acc:p78426]	2859	1	0.00001	0.00001
homeobox protein otx1. [swissprot;acc:p32242]	1520	1.01778	244.367	240.098
homeobox protein otx2. [swissprot;acc:p32243]	1521	1.01776	244.478	240.212
homeobox protein prh (hematopoietically expressed homeobox) (homeobox protein hex). [swissprot;acc:q03014]	1709	1.01346	198.014	195.385
homeobox protein six1 (sine oculis homeobox homolog 1). [swissprot;acc:q15475]	1128	1.02733	221.286	215.399
homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	1129	1.02732	221.285	215.401
homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	107	1.24907	252.309	201.998
homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	104	1.24926	252.371	202.016
homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	108	1.24902	252.296	201.995
homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (methyl methanesulfonate (mmf)-inducible fragment protein 1). [swissprot;acc:q15011]	3196	1	0.00001	0.00001
homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]	3053
homolog of yeast maf1. [refseq;acc:nm_032272]	1977	1.00969	209.539	207.529
hormone sensitive lipase (ec 3.1.1.-) (hsl). [swissprot;acc:q05469]	3172	1	0.00001	0.00001
hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	289	1.10486	272.781	246.892
hrd1 protein isoform a; synoviolin1. [refseq;acc:nm_032431]	2231	1.00633	221.842	223.246
hsgcn1 (fragment). [sptrembl;acc:q99736]	2712	1.00057	220.521	220.395
hskin17 protein. [refseq;acc:nm_012311]	1697	1.01367	217.624	214.69
hsp90 co-chaperone cdc37 (hsp90 chaperone protein kinase-targeting subunit) (p50cdc37). [swissprot;acc:q16543]	2258	1.00582	223.888	225.191
human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]	1486	1.01906	207.877	203.989
human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]	1488
huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	1995	1.00936	188.961	190.73
huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	1993	1.00943	189.052	190.835
huntingtin interacting protein c. [refseq;acc:nm_012272]	195	1.13748	227.971	200.417
huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	729	1.05187	208.874	219.708
huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	949	1.0354	217.253	209.826
huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	179	1.16476	226.884	194.79
hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	2415	1.00359	218.2	218.984
hus1 checkpoint protein; hus1 (s. pombe) checkpoint homolog; hus1+-like protein. [refseq;acc:nm_004507]	2191	1.00662	209.54	208.162
hyaluronan binding protein 4; intracellular antigen detected by monoclonal antibody ki-1; intracellular hyaluronan-binding protein; chromodomain helicase dna binding protein 3 interacting protein. [refseq;acc:nm_014282]	2192
hyaluronan synthase 1 (ec 2.4.1.212) (hyaluronate synthase 1) (hyaluronic acid synthase 1) (ha synthase 1) (huhas1). [swissprot;acc:q92839]	1294	1.024	221.093	226.399
hyaluronan synthase 2 (ec 2.4.1.212) (hyaluronate synthase 2) (hyaluronic acid synthase 2) (ha synthase 2). [swissprot;acc:q92819]	1291
hyaluronan synthase 3 (ec 2.4.1.212) (hyaluronate synthase 3) (hyaluronic acid synthase 3) (ha synthase 3). [swissprot;acc:o00219]	1295
hydroxyacid oxidase 1 (ec 1.1.3.15) (haox1) (glycolate oxidase) (gox). [swissprot;acc:q9ujm8]	1104	1.0283	231.922	238.486

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.